2031 completed, 513 unknown, 400 recruiting, 251 terminated. 1325 Not applicable, 511 Phase 2, 340 Phase 3, 315 Phase 1, 226 Phase 4.
Follow Demyelinating Autoimmune Diseases, CNS: new trials by email Literature Review of Demyelinating Autoimmune Diseases, CNS trials Research Report on Demyelinating Autoimmune Diseases, CNS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Vigorous Versus Low Intensity Cool Room Treadmill Training in People with Multiple Sclerosis Body-weight supported treadmill training in a room cooled to 16°C - Multiple Sclerosis, Neurological Rehabilitation | Not applicable | Withdrawn | Memorial University of Newfoundland | 2030-01-01 | 2024-11-27 | |
| Inductive Therapeutic Exercise in Multiple Sclerosis Experimental: Inductive Therapeutic Exercise (ETI), Control: Sham Inductive Therapeutic Exercise (sham-ETI) - Multiple Sclerosis | Not applicable | Not yet recruiting | Fundación San Juan De Dios | 30 | 2027-10-01 | 2026-10-02 |
| Exploring Reproductive Decision-Making Among Women With Multiple Sclerosis Multiple Sclerosis | Not yet recruiting | Assiut University | 272 | 2027-06-01 | 2026-09-21 | |
| A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS Remibrutinib (Open Label) - Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Secondary Progressive | Phase 2 | Not yet recruiting | Moein Amin | 20 | 2027-03-01 | 2026-08-19 |
| C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Progressive Multiple Sclerosis Refractory to Standard Therapy C-CAR168 - Multiple Sclerosis, Primary Progressive Multiple Sclerosis | Phase 1 / Phase 2 | Not yet recruiting | AbelZeta Inc. | 119 | 2027-02-01 | 2026-10-13 |
| Exercise With and Without Cognitive Training Effect of Exercise with and Without Cognitive Training on Gait - Multiple Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-01-04 | 2026-03-03 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Lead Exposure and Multiple Sclerosis Multiple Sclerosis | Not yet recruiting | Assiut University | 140 | 2026-12-30 | 2026-02-20 | |
| Local Vibration and Ankle Mobilization in Multiple Sclerosis Local Vibration, Ankle Joint Mobilization - Multiple Sclerosis | Not applicable | Not yet recruiting | Gaziantep Islam Science and Technology University | 60 | 2026-12-15 | 2026-10-19 |
| A Basket Study of CTA313 in Participants With Active Autoimmune Diseases CTA313 UCAR T Cell Infusion - Systemic Lupus Erthematosus (SLE), Progressive Multiple Sclerosis (PMS) | Phase 1 | Not yet recruiting | Imviva Bio | 81 | 2026-12-01 | 2026-08-24 |
| Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care Cohort - Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive | Not yet recruiting | Luxembourg Institute of Health | 100 | 2026-12-01 | 2026-09-22 | |
| Safety and Efficacy of BAFFR CART for Relapsed/ Refractory Neuromyelitis Optica Spectrum Disorder Anti-BAFFR CART - Neuromyelitis Optica Spectrum Disorder | Phase 1 / Phase 2 | Not yet recruiting | Tianjin Medical University General Hospital | 20 | 2026-12-01 | 2026-10-16 |
| Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis Autologous haemopoietic stem cell transplantation - Multiple Sclerosis | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 20 | 2026-12-01 | 2026-10-16 |
| Behavioral Intervention for Physical Activity and Sexual Dysfunction in Multiple Sclerosis Behavioural intervention for physical activity for multiple sclerosis (BIPAMS) - Multiple Sclerosis, Relapsing-Remitting, Sexual Dysfunction | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 30 | 2026-12-01 | 2025-12-22 |
| [18F]F-DED PET Imaging of Reactive Astrocytes in Multiple Sclerosis [18F]fluorodeprenyl-D2 - Multiple Sclerosis | Not applicable | Not yet recruiting | Parc de Salut Mar | 30 | 2026-12-01 | 2026-09-04 |
| Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care MS Boost, Standard of care - Multiple Sclerosis, Fatigue Syndrome, Chronic | Not applicable | Not yet recruiting | Ad scientiam | 208 | 2026-12-01 | 2025-10-03 |
| Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis. Online wellness course and online exercise platform, Usual Care Group - Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS) | Not applicable | Not yet recruiting | University of Iowa | 118 | 2026-11-15 | 2026-09-28 |
| The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis Moderate-Intensity Continuous Training (MICT), High-Intensity Interval Training (HIIT) - Multiple Sclerosis, High-intensity Interval Training | Not applicable | Not yet recruiting | Hacettepe University | 40 | 2026-11-01 | 2026-09-23 |
| Driving Performance in Parkinson's Disease and Multiple Sclerosis Using a Driving Simulator Standardized Driving Simulator Assessment - Parkinson, Multiple Sclerosis | Not yet recruiting | University Hospital Olomouc | 100 | 2026-11-01 | 2026-09-09 | |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
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Multiple Sclerosis (3146) · Multiple Sclerosis, Relapsing-Remitting (612) · Multiple Sclerosis, Chronic Progressive (242) · Fatigue (210) · Neuromyelitis Optica (171) · Motor Activity (170) · Stroke (105) · Parkinson Disease (97) · Muscle Spasticity (76) · Cognitive Dysfunction (75) · Demyelinating Diseases (73) · Spinal Cord Injuries (72) · Autoimmune Diseases (70) · Depression (70) · Nervous System Diseases (59)
Immune System Diseases (3668) · Autoimmune Diseases of the Nervous System (3642) · Nervous System Diseases (3628) · Autoimmune Diseases (3617) · Demyelinating Diseases (3614) · Pathological Conditions, Signs and Symptoms (946) · Signs and Symptoms (543) · Pathologic Processes (456) · Multiple Sclerosis (401) · Disease Attributes (379) · Central Nervous System Diseases (325) · Chronic Disease (303) · Behavior (291) · Neurologic Manifestations (272)
Interferon beta-1a (106) · ocrelizumab (82) · Dimethyl Fumarate (70) · Exercise (70) · Natalizumab (66) · Interferon beta-1b (64) · Fingolimod Hydrochloride (57) · Glatiramer Acetate (55) · teriflunomide (40) · Methylprednisolone (38) · Rituximab (37) · Blood Specimen Collection (35) · 4-Aminopyridine (33) · ofatumumab (33) · Alemtuzumab (30)
Biogen (160) · Novartis Pharmaceuticals (92) · Merck KGaA, Darmstadt, Germany (49) · Bayer (47) · Hoffmann-La Roche (39) · Hasselt University (34) · Johns Hopkins University (32) · Kessler Foundation (32) · Assiut University (30) · Fondazione Don Carlo Gnocchi ETS (30) · National Institute of Neurological Disorders and Stroke (NINDS) (30) · Sanofi (30) · University of Washington (28) · Gazi University (27) · NYU Langone Health (26)
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Daniel S Reich, M.D. (11) · Cagla Ozkul (9) · Michael Levy, MD, PhD (9) · Peter Feys, prof. dr. (9) · Eric Thouvenot (8)
PMID 31072380, PMID 21387374, PMID 33023488, PMID 32447743, PMID 34882037, PMID 23669008, PMID 25475413, PMID 27411694, PMID 27733070, PMID 29275977, PMID 30918100, PMID 31654272, PMID 31762387, PMID 32710396, PMID 36163349, PMID 37652990, PMID 37745914, PMID 39935588, PMID 40258203, PMID 40756531, PMID 40966534, PMID 42328798, PMID 6685237, PMID 12525714, PMID 22622860, PMID 23531349, PMID 24131282, PMID 25245812, PMID 26932146, PMID 28002679, PMID 28002688, PMID 28825348, PMID 30144037, PMID 31675266, PMID 32426039, PMID 32539719, PMID 33414927, PMID 34035833, PMID 34376508, PMID 34378446, PMID 35003076, PMID 36619856, PMID 37272540, PMID 39251561, PMID 40743487, PMID 42368888, PMID 42624921, PMID 7613530, PMID 10022678, PMID 11955556
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