201 completed, 21 terminated, 12 unknown, 10 recruiting. 206 Phase 1, 15 Phase 2, 10 Phase 4, 5 Not applicable, 3 Phase 3.
By phase and status
Phase Trials Status Phase 1 206 Completed 177 , Terminated 14 , Recruiting 8 , Unknown 3 , Withdrawn 2 , Active not recruiting 1 , Not yet recruiting 1 Phase 2 15 Completed 8 , Unknown 4 , Terminated 2 , Withdrawn 1 Phase 4 10 Terminated 5 , Completed 4 , Withdrawn 1 Not applicable 5 Completed 2 , Active not recruiting 1 , Recruiting 1 , Unknown 1 Phase 3 3 Completed 1 , Terminated 1 , Unknown 1 Early Phase 1 1 Completed 1
Follow Renal Impairment: new trials by email Literature Review of Renal Impairment trials Research Report on Renal Impairment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix .
Trial Phase Status Sponsor Enrollment Start Updated
Study of Sulthiame (S-054502) in Participants With Renal Impairment and Matched Healthy Controls Sulthiame - Renal Impairment Phase 1 Not yet recruiting Shionogi 30 2026-09-29 2026-10-05 Study to Assess the Plasma Concentration of Rilzabrutinib Given as a Tablet to Adult Participants With Severe Renal Impairment Compared to Matched Participants With Normal Renal Function rilzabrutinib - Renal Impairment, Healthy Volunteers Phase 1 Recruiting Sanofi 16 2026-09-22 2026-10-23 Renal Impairment Pharmacokinetics (PK) Trial of Afabicin Afabicin Oral, Afabicin IV - Renal Impairment Phase 1 Recruiting Debiopharm International SA 60 2026-09-16 2026-10-26 Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-C Nephrotoxicity, Bacterial Infections Not yet recruiting King Faisal Specialist Hospital & Research Center 304 2026-09-15 2026-09-14 A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions RO7795081 - Renal Impairment Phase 1 Recruiting Hoffmann-La Roche 60 2026-09-09 2026-10-09 A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide Ribupatide - End Stage Renal Disease, Renal Impairment Phase 1 Recruiting Kailera 32 2026-09-08 2026-10-01 The Study is to Investigate D-2570 in Participants With Different Levels of Kidney Function. D-2570 - Renal Impairment Phase 1 Recruiting InventisBio Co., Ltd 40 2026-08-08 2026-10-13 A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease INCB123667 - Renal Impairment Phase 1 Recruiting Incyte Corporation 16 2026-05-29 2026-06-16 Pharmacokinetics of VC005 Tablets in Subjects With Renal Impairment and Normal Renal Function VC005 Tablets - Renal Impairment Phase 1 Completed Jiangsu vcare pharmaceutical technology co., LTD 32 2026-05-09 2026-08-20 A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006) MK-2828 - Chronic Kidney Failure, End-Stage Renal Disease Phase 1 Completed Merck Sharp & Dohme LLC 18 2026-03-02 2026-09-15 A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function LY3841136 - Kidney Disease, Renal Insufficiency Chronic Phase 1 Active not recruiting Eli Lilly and Company 28 2026-02-24 2026-08-19 A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function PF-07328948 - Renal Impairment, Healthy Phase 1 Recruiting Pfizer 28 2026-01-28 2026-05-12 A Study of S-892216-PO in Participants With Renal Impairment and Matched Controls S-892216-PO - Renal Impairment Phase 1 Completed Shionogi 24 2025-10-16 2026-10-22 A Study of Pharmacokinetics and Safety of LY3537031 in Participants With Normal Renal Function and Participants With Renal Impairment LY3537031 - Renal Impairment, Healthy Phase 1 Completed Eli Lilly and Company 31 2025-09-18 2026-04-24 DESIR. Evaluation of the Pre-therapeutic Activity of Dihydropyrimidine dEShydrogenase (DPD) in Patients With Cancer and/or Renal Failure blood sampling, Blood sampling - Renal Impairment, Digestive Cancers Not yet recruiting Centre Hospitalier Universitaire de Besancon 742 2025-09-01 2025-09-17 Study of BPN14770 in Participants With Severe Renal Impairment and Healthy Controls BPN14770 - Renal Impairment Phase 1 Completed Shionogi 14 2025-08-25 2026-02-27 Investigation of the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Opemalirsen (AZD2373) Opemalirsen (AZD2373) - Renal Impairment Phase 1 Completed AstraZeneca 35 2025-08-18 2026-06-26 Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes Renal assist device - Renal Impairment After Cardiac Surgery, Renal Impairment Not applicable Recruiting 3ive Labs 124 2025-07-16 2026-03-19 An Investigational Study of ESK-001 in Participants With Normal Renal Function and Participants With Mild, Moderate, and Severe Impaired Renal Function ESK-001 - Renal Impairment Phase 1 Completed Alumis Inc 16 2025-04-23 2025-12-10 Pharmacokinetics of Petrelintide Following Administration to Participants With Impaired Renal Function Petrelintide - Renal Impairment Phase 1 Completed Zealand Pharma 39 2025-04-15 2026-01-28
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Narrower conditions Renal Insufficiency (253) · Kidney Diseases (15) · Kidney Failure, Chronic (15) · Diabetes Mellitus, Type 2 (8) · Acute Kidney Injury (6) · Diabetes Mellitus (5) · Lymphoma, Follicular (5) · Renal Insufficiency, Chronic (5) · Heart Failure (4) · Multiple Myeloma (4) · Neoplasms (3) · Anemia (2) · Blood Protein Disorders (2) · Cardiomyopathies (2) · Coronary Artery Disease (2)
Broader conditions Female Urogenital Diseases (253) · Female Urogenital Diseases and Pregnancy Complications (253) · Male Urogenital Diseases (253) · Urogenital Diseases (253) · Urologic Diseases (252) · Kidney Diseases (238) · Pathological Conditions, Signs and Symptoms (26) · Pathologic Processes (23) · Cardiovascular Diseases (19) · Chronic Disease (19) · Disease Attributes (19) · Nutritional and Metabolic Diseases (15) · Metabolic Diseases (14) · Glucose Metabolism Disorders (12) · Hemic and Lymphatic Diseases (12)
Interventions Dexamethasone (4) · Blood Specimen Collection (3) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (2) · AT-511 (2) · Cardiopulmonary Bypass (2) · Cefepime (2) · Furosemide (2) · Sodium Chloride (2) · Sugammadex (2) · Tablets (2) · Tadalafil (2) · iodixanol (2) · ioversol (2) · isatuximab (2) · pomalidomide (2)
Sponsors AstraZeneca (16) · Pfizer (14) · Merck Sharp & Dohme LLC (13) · Novartis Pharmaceuticals (12) · Bayer (5) · Sanofi (5) · Shionogi (5) · Bristol-Myers Squibb (4) · Takeda (4) · AbbVie (3) · Amgen (3) · Assiut University (3) · Astellas Pharma Global Development, Inc. (3) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3) · Eisai Inc. (3)
Countries United States (135) · Germany (35) · China (13) · Bulgaria (8) · Canada (8) · Hungary (7) · Czechia (6) · Japan (6) · Sweden (6) · New Zealand (5) · Poland (5) · Romania (5) · South Korea (5) · Spain (5) · France (4)
Top investigators Thomas Marbury, MD (3) · Evangelos Terpos, Prof (2)
Results publications PMID 19853704 , PMID 21960668 , PMID 23737404 , PMID 24030917 , PMID 24408516 , PMID 24760402 , PMID 24946021 , PMID 25136024 , PMID 25529979 , PMID 26475802 , PMID 26519231 , PMID 26894653 , PMID 27881568 , PMID 28115515 , PMID 28254177 , PMID 28349386 , PMID 28365033 , PMID 28487034 , PMID 28615304 , PMID 28679468 , PMID 28703316 , PMID 29263061 , PMID 29424480 , PMID 29519811 , PMID 29891610 , PMID 30012756 , PMID 30194585 , PMID 30397067 , PMID 30487984 , PMID 30610026 , PMID 30680407 , PMID 31047001 , PMID 31064405 , PMID 31217993 , PMID 31332068 , PMID 31630870 , PMID 31632000 , PMID 31919012 , PMID 32579796 , PMID 32750311 , PMID 32868037 , PMID 33388951 , PMID 33813736 , PMID 34115385 , PMID 34213819 , PMID 34637151 , PMID 34857877 , PMID 35001638 , PMID 35018553 , PMID 35361478
NIH funding 2018 (5), 2017 (4), 2019 (3), 2008 (2), 2014 (2), 2016 (1), 2023 (1)