18 completed, 6 unknown, 4 recruiting, 2 terminated. 9 Not applicable, 9 Phase 4, 7 Phase 3, 4 Phase 2, 3 Phase 1.
Follow Prophylaxis: new trials by email Literature Review of Prophylaxis trials Research Report on Prophylaxis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States Doxycycline, Standard of Care (SOC) - Chlamydia Females, Gonorrhea Female | Phase 4 | Not yet recruiting | Tulane University | 519 | 2027-01-01 | 2026-07-15 |
| Cabotegravir-Hormone PK/PD Interactions for HIV Prevention Cabotegravir Injectable Suspension (CAB LA) - HIV, Prophylaxis | Phase 1 | Recruiting | Johns Hopkins University | 32 | 2026-07-07 | 2026-07-13 |
| Post-ERCP Pancreatitis - Prophylactic Measures Implementation Study (PEP-PROMIS) Pancreatitis, Acute, ERCP | Completed | Branislav Kuncak | 1135 | 2025-12-01 | 2026-08-25 | |
| Monitoring of Anti-TFPI in Hemophilia blood sampling - Hemophilia, Rebalancing Agents | Recruiting | Hospices Civils de Lyon | 11 | 2025-10-23 | 2026-03-23 | |
| Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction Apixaban 2.5 MG PO BID, Control (Standard treatment) - Acute Myocardial Infarction of Anterior Wall, Left Ventricular Thrombus | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 472 | 2024-12-02 | 2024-12-19 |
| Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes Antibiotic regimen 1: sulbactam + ampicillin + azithromycin, Antibiotic regimen 2: ceftriaxone + clarithromycin + amoxicillin - Preterm Premature Rupture of Membranes (PPROM), Prophylaxis | Not applicable | Completed | Yuzuncu Yil University | 40 | 2024-10-01 | 2025-08-29 |
| Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis Amitriptyline, Flunarizine 5mg - Migraine, Prophylaxis | Not applicable | Unknown | Shalamar Institute of Health Sciences | 84 | 2024-01-01 | 2023-12-29 |
| L-AmB_ Retrospective mUlticenter Study on Mycosis prOphylaxis Liposomal Amphotericin B (LAmB) - Invasive Fungal Infections, Prophylaxis | Enrolling by invitation | Istituto Giannina Gaslini | 120 | 2023-12-12 | 2025-05-04 | |
| Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures Vitamin C, Placebo - Distal Radius Fracture, Vitamine c | Phase 4 | Completed | Damascus University | 220 | 2023-06-15 | 2026-03-19 |
| Study of Low Molecular Weight Heparins Dalteparin Prefilled Syringe, Tinzaparin profiled syringe - Anticoagulant, Venous Thromboembolism | Phase 4 | Unknown | Herlev Hospital | 65000 | 2023-03-23 | 2023-08-31 |
| Regional and Intravenous Dexamethasone in The Prophylaxis of Rebound Pain After Supraclavicular Block in Upper Limb Surgeries Regional Dexamethasone, Intravenous Dexamethasone - Regional, Intravenous | Not applicable | Completed | Tanta University | 90 | 2023-03-01 | 2025-07-20 |
| Escalating Monthly Doses of Tafenoquine in Healthy Volunteers Tafenoquine prophylaxis - Prophylaxis | Phase 4 | Unknown | Naval Medical Research Center | 200 | 2022-05-10 | 2022-04-11 |
| Pre-Exposure Prophylaxis (PrEP)- Gender Affirming Hormone Therapy (GAHT) Interactions in TGW Truvada alone, Truvada plus Leuprolide 11.25mg intramuscular injection, Truvada plus Estradiol 1 mg - HIV, Prophylaxis | Phase 1 | Completed | Johns Hopkins University | 13 | 2021-03-01 | 2026-04-06 |
| Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022) Islatravir, Placebo to FTC/TDF, FTC/TDF - HIV-I, Human Immunodeficiency Virus Type 1 | Phase 3 | Terminated | Merck Sharp & Dohme LLC | 730 | 2021-02-24 | 2026-02-04 |
| Improved Adherence With Extended Venous Thromboembolism Prophylaxis After Major Cancer Surgery Apixaban 2.5 milligram - Neoplasms Malignant, Surgery | Phase 4 | Completed | McMaster University | 53 | 2021-02-22 | 2022-04-22 |
| Rapid Development and Implementation of a Remote ECG-monitored Prospective Randomized Clinical Trial During a Pandemic: Hydroxychloroquine Prophylaxis in COVID-19 Household Contacts Hydroxychloroquine - Covid19, Hydroxychloroquine | Phase 4 | Completed | Bryn Mawr Hospital | 54 | 2020-05-27 | 2020-12-03 |
| Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19) Hydroxychloroquine - COVID19, Hydroxychloroquine | Phase 2 | Terminated | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | 155 | 2020-05-14 | 2025-03-10 |
| Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals Hydroxychloroquine (HCQ), Placebo oral tablet - COVID19, Sars-CoV2 | Phase 3 | Withdrawn | Abderrahmane Mami Hospital | 2020-04-28 | 2020-08-28 | |
| Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP) Hydroxychloroquine, Placebo - COVID-19, Corona Virus Infection | Phase 3 | Unknown | Louisiana State University Health Sciences Center in New Orleans | 1700 | 2020-04-27 | 2020-09-02 |
| Mesenchymal Stem Cells for the Treatment of COVID-19 PrimePro, Placebo - Covid19, Prophylaxis | Phase 1 | Completed | Thomas Advanced Medical LLC | 40 | 2020-04-24 | 2020-10-05 |
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COVID-19 (6) · Venous Thromboembolism (3) · Angioedemas, Hereditary (2) · Coronavirus Infections (2) · Hemophilia A (2) · Invasive Fungal Infections (2) · Acquired Immunodeficiency Syndrome (1) · Anterior Wall Myocardial Infarction (1) · Candidiasis, Invasive (1) · Clostridium Infections (1) · Dysbiosis (1) · Endophthalmitis (1) · Graft vs Host Disease (1) · Malaria (1) · Medication Adherence (1)
Infections (14) · Lung Diseases (7) · RNA Virus Infections (7) · Respiratory Tract Diseases (7) · Virus Diseases (7) · Cardiovascular Diseases (6) · Coronaviridae Infections (6) · Nidovirales Infections (6) · Pneumonia (6) · Pneumonia, Viral (6) · Respiratory Tract Infections (6) · Vascular Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Coronavirus Infections (4) · Genetic Diseases, Inborn (4)
Hydroxychloroquine (5) · Blood Specimen Collection (2) · Cefazolin (2) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (2) · berotralstat (2) · Amitriptyline (1) · Amoxicillin (1) · Ampicillin (1) · Ascorbic Acid (1) · Azithromycin (1) · Caffeine (1) · Ciprofloxacin (1) · Clarithromycin (1) · Doxycycline (1) · Emtricitabine (1)
BioCryst Pharmaceuticals (2) · Johns Hopkins University (2) · Abderrahmane Mami Hospital (1) · Ain Shams University (1) · BioGaia AB (1) · Branislav Kuncak (1) · Brigham and Women's Hospital (1) · Bryn Mawr Hospital (1) · Chulalongkorn University (1) · Damascus University (1) · Daniela Francescato Veiga (1) · GeoSentinel Foundation (1) · Henry Ford Health System (1) · Herlev Hospital (1) · Hospices Civils de Lyon (1)
United States (11) · Italy (3) · Australia (2) · Denmark (2) · France (2) · Pakistan (2) · Slovakia (2) · South Africa (2) · Austria (1) · Brazil (1) · Canada (1) · China (1) · Czechia (1) · Egypt (1) · Germany (1)
Bradley A Connor, MD (1) · Daniela F Veiga, MD, PhD (1) · Darintr Sosothikul, Asso professer (1) · Ernst R Von Schwarz, MD, PhD (1) · Giovanni Martinelli, Prof. (1) · Henriette Farkas, MD (1) · Jalila Ben Khelil, Pr (1) · Jan Martinek, Prof, MD, Ph.D (1) · Karel Allegaert, MD PhD (1) · Mark A Marzinke (1) · Mark A Marzinke, PhD (1) · Michael D Edstein, PhD (1)
PMID 26441216, PMID 30259200, PMID 32736597, PMID 34037911, PMID 34161665, PMID 34493311, PMID 34499720, PMID 35281991, PMID 35362102, PMID 35820771, PMID 36268304, PMID 36408587, PMID 36791845, PMID 38006972, PMID 38020288, PMID 39019103, PMID 40490218, PMID 40857697
R01AI145675 (1), R01AI186440 (1)