465 completed, 97 unknown, 71 recruiting, 57 terminated. 156 Phase 3, 122 Not applicable, 98 Phase 1, 72 Phase 2, 67 Phase 4.
Follow this condition Literature Review of Hemophilia A trials Research Report on Hemophilia A
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lentiviral FVIII Gene Therapy YUVA-GT-F801 - Hemophilia A | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2027-06-01 | 2026-09-01 |
| Post Approval Phase 4 Study to Learn More About How Safe Octocog Alfa is, and How Well it Works in Patients With Severe Hemophilia A in India Octocog alfa - Severe Hemophilia A | Not yet recruiting | Bayer | 30 | 2027-04-05 | 2026-10-21 | |
| Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy Multicomponent pain self-management programme - Hemophilic Arthropathy, Chronic Pain | Not applicable | Not yet recruiting | Investigación en Hemofilia y Fisioterapia | 70 | 2027-03-01 | 2026-10-06 |
| Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%) Joint Ultrasound (HEAD-US), Blood Sample for Coagulation Factor Measurement - Mild Hemophilia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 150 | 2027-02-01 | 2026-08-17 |
| Efanesoctocog Prophylaxis Or The Optimization Of Treatment: Real-World Experience Of Taylorizing Clotting Therapy In Hemophilia A Study questionnaires, Clinical/pharmacological data collection - Hemophilia A Patient | Not yet recruiting | Nantes University Hospital | 553 | 2027-01-01 | 2026-09-25 | |
| Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A FRSW107 - Severe Hemophilia A | Phase 3 | Not yet recruiting | Hangzhou Gensciences Biopharmaceutical Co., Ltd. | 76 | 2026-12-25 | 2024-06-20 |
| Clinical Trial of NXT007 for the Prophylactic Treatment of Hemophilia A in Infants and Children NXT007 - Hemophilia A | Phase 3 | Not yet recruiting | Hoffmann-La Roche | 50 | 2026-11-30 | 2026-10-19 |
| A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A Denecimig - Haemophilia A | Phase 3 | Not yet recruiting | Novo Nordisk A/S | 84 | 2026-10-09 | 2026-09-21 |
| A Study to Learn About the Study Medicine (Called Marstacimab) in People With Hemophilia A or B Marstacimab - Hemophilia | Not yet recruiting | Pfizer | 100 | 2026-10-05 | 2026-10-05 | |
| A Study of Elranatamab for Inhibitor Eradication in Patients With Hemophilia A Elranatamab - Hemophilia A With Inhibitors | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 20 | 2026-10-01 | 2026-08-26 |
| Liver Biopsy Following Gene Therapy For Hemophilia Liver Biopsy - Hemophilia A, Hemophilia B | Not yet recruiting | St. Jude Children's Research Hospital | 8 | 2026-10-01 | 2026-09-17 | |
| A Phase 2 Study of Foscenvivint in Liver Cirrhosis Patients Caused by HIV/HCV Co-infection With Hemophilia Foscenvivint - Liver Cirrhosis | Phase 2 | Recruiting | Kiminori Kimura, MD | 7 | 2026-10-01 | 2026-10-05 |
| A Phase III Clinical Trial Evaluating SR604 Injection for Prophylactic Treatment in Patients With Hemophilia SR604 - Hemophilia A, Hemophilia A and B | Phase 3 | Not yet recruiting | Shanghai RAAS Blood Products Co., Ltd. | 90 | 2026-09-30 | 2026-10-15 |
| Study of a Smart Sharps Disposal Device in Patients With Hemophilia The smart Sharps device is given to the patient and they use it to throw needles away in. It is not internal to the patient. - Hemophilia A and B | Not applicable | Not yet recruiting | University of Pennsylvania | 23 | 2026-09-30 | 2026-07-09 |
| Patient Preferences in Treatment of Haemophilia A With and Without Inhibitors: a Discrete Choice Experiment in Germany No treatment given - Haemophilia A | Enrolling by invitation | Novo Nordisk A/S | 150 | 2026-09-25 | 2026-10-06 | |
| A Prospective Assessment of Bone Health in Patients With Severe Hemophilia A on Factor VIII vs Factor Mimetic Prophylaxis (Efa Emi Bone Health Study) Hemophilia a | Recruiting | Arkansas Children's Hospital Research Institute | 50 | 2026-09-21 | 2026-10-05 | |
| A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A SPK-8011QQ - Hemophilia A | Phase 1 / Phase 2 | Recruiting | Hoffmann-La Roche | 5 | 2026-09-08 | 2026-10-13 |
| SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis Emicizumab, FEIBA, rFVIIa - Hemophilia A | Phase 3 | Recruiting | Emory University | 5 | 2026-09-01 | 2026-08-21 |
| Validity and Reliability of the Figure-of-Eight Walking and Weight-Bearing Lunge Tests in Hemophilia Hemophilia | Recruiting | Yuzuncu Yil University | 36 | 2026-08-30 | 2026-10-01 | |
| 3D Ultrasound in Hemophilic Ankles Mechanical Ultrasound - Hemophilia | Not applicable | Enrolling by invitation | The Hospital for Sick Children | 11 | 2026-08-25 | 2026-10-14 |
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Hemophilia B (137) · Hematologic Diseases (33) · Blood Coagulation Disorders (32) · Joint Diseases (30) · Coagulation Protein Disorders (27) · Hemostatic Disorders (26) · Hemorrhagic Disorders (22) · Genetic Diseases, Inborn (20) · Motor Activity (18) · Blood Coagulation Disorders, Inherited (17) · Hemorrhage (15) · Hemarthrosis (14) · von Willebrand Diseases (14) · Pain (12)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (787) · Hemic and Lymphatic Diseases (787) · Blood Coagulation Disorders, Inherited (770) · Genetic Diseases, Inborn (767) · Hemorrhagic Disorders (765) · Coagulation Protein Disorders (760) · Blood Coagulation Disorders (755) · Hematologic Diseases (754) · Genetic Diseases, X-Linked (134) · Pathological Conditions, Signs and Symptoms (82) · Musculoskeletal Diseases (71) · Pathologic Processes (49) · Signs and Symptoms (40) · Cardiovascular Diseases (37) · Neurologic Manifestations (37)
Factor VIII (125) · F8 protein, human (52) · emicizumab (33) · BAY 14-2222 (22) · factor VIII-Fc fusion protein (19) · recombinant factor VIII N8 (19) · BAX 855 (18) · Injections (16) · recombinant factor VIII SQ (14) · Blood Specimen Collection (11) · marstacimab (11) · BIVV001 (10) · recombinant FVIIa (10) · von Willebrand Factor (10) · Surveys and Questionnaires (9)
Novo Nordisk A/S (68) · Bayer (57) · Baxalta now part of Shire (40) · Pfizer (34) · Investigación en Hemofilia y Fisioterapia (20) · Hoffmann-La Roche (17) · Octapharma (15) · Swedish Orphan Biovitrum (14) · CSL Behring (13) · Wyeth is now a wholly owned subsidiary of Pfizer (12) · Institute of Hematology & Blood Diseases Hospital, China (11) · BioMarin Pharmaceutical (10) · Hospices Civils de Lyon (10) · Sanofi (9) · Hangzhou Gensciences Biopharmaceutical Co., Ltd. (8)
United States (271) · Spain (167) · France (142) · United Kingdom (140) · Italy (138) · Germany (134) · Canada (98) · Turkey (Türkiye) (92) · China (86) · Japan (75) · Poland (69) · Taiwan (67) · Austria (62) · Netherlands (62) · Sweden (61)
Lei Zhang, MD (6) · Renchi Yang, PhD (6)
PMID 42698050, PMID 19216617, PMID 35939785, PMID 25495795, PMID 26931631, PMID 31697801, PMID 33719084, PMID 39091324, PMID 17687129, PMID 22212248, PMID 22765835, PMID 25273984, PMID 26157075, PMID 26679394, PMID 27002680, PMID 28691557, PMID 29224506, PMID 30157389, PMID 32293786, PMID 32744769, PMID 32915950, PMID 33269010, PMID 34788507, PMID 34922648, PMID 35879931, PMID 36796484, PMID 36884286, PMID 39341368, PMID 39642315, PMID 40099428, PMID 40347119, PMID 40750723, PMID 40986187, PMID 41637644, PMID 10529148, PMID 10792474, PMID 10960937, PMID 12828678, PMID 1347102, PMID 1374895, PMID 14719175, PMID 15230949, PMID 15357767, PMID 15374882, PMID 15870545, PMID 16236109, PMID 1640190, PMID 1689390, PMID 16919083, PMID 16990605
2023 (14), 2015 (12), 2016 (12), 2017 (12), 2008 (11), 2014 (9), 2009 (8), 2018 (6), 2019 (4), 2025 (4), 2005 (3), 1UG3HL165064-01 (1), 2004 (1), K23HL105785 (1), R01AI049508 (1)