8 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 14 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 14 | Completed 8, Unknown 2, Not yet recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Prehypertension: new trials by email Literature Review of Prehypertension trials Research Report on Prehypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neurovascular Effects of Empagliflozin Empagliflozin (EMPA), Placebo - Blood Pressure, Endothelial Dysfunction | Phase 4 | Not yet recruiting | Kanokwan Bunsawat | 100 | 2026-09-01 | 2026-09-02 |
| Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes-----renal Substudy Allisartan Isoproxil, Amlodipine - Diabetes Mellitus, Type 2, Blood Pressure | Phase 4 | Withdrawn | Guangdong Provincial People's Hospital | 2021-09-01 | 2022-08-26 | |
| Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes Allisartan Isoproxil, Amlodipine 5mg, Standard treatment by current guideline - Diabetes Mellitus, Type 2, Adverse Event | Phase 4 | Recruiting | XueQing Yu | 11414 | 2018-02-01 | 2026-09-14 |
| Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension Dapagliflozin, Placebo - Cap - PreDiabetes, Prehypertension | Phase 4 | Completed | University of Guadalajara | 30 | 2016-03-30 | 2020-11-09 |
| Prehypertension and Dietary Supplements - The PYRAMIDS Study Life-style modifications, Dietary supplements - Prehypertension | Phase 4 | Unknown | University of Roma La Sapienza | 500 | 2014-01-01 | 2013-03-07 |
| Nebivolol and Endothelial Regulation of Fibrinolysis (NERF) Nebivolol, Metoprolol, Placebo - Prehypertension, Hypertension | Phase 4 | Completed | University of Colorado, Boulder | 44 | 2012-02-01 | 2019-06-25 |
| Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure Febuxostat - Prehypertension, Gout | Phase 4 | Completed | University of California, San Diego | 47 | 2011-10-01 | 2019-12-16 |
| Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects aliskiren 300 mg once daily, Placebo/sugar pill - Diabetes, Pre-hypertension | Phase 4 | Terminated | University of Alabama at Birmingham | 21 | 2011-06-01 | 2017-05-11 |
| Nebivolol and the Endothelin (ET)-1 System Nebivolol, Metoprolol, Placebo - Prehypertension, Hypertension | Phase 4 | Completed | University of Colorado, Boulder | 42 | 2011-05-01 | 2019-01-02 |
| Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension Amiloride - Prehypertension | Phase 4 | Unknown | Augusta University | 32 | 2010-09-01 | 2012-10-23 |
| Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension Nebivolol - Pre-hypertension, Hypertension | Phase 4 | Completed | University of California, San Diego | 50 | 2010-07-01 | 2019-08-21 |
| Angiotensin II Blockade and Inflammation in Obesity Olmesartan medoxomil - Overweight, Obese | Phase 4 | Completed | Virginia Polytechnic Institute and State University | 20 | 2009-02-01 | 2018-01-03 |
| Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients CPAP - Obstructive Sleep Apnea | Phase 4 | Completed | University of Sao Paulo | 36 | 2008-08-01 | 2010-10-28 |
| A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome valsartan plus hydrochlorothiazide - METABOLIC SYNDROME, HYPERTENSION | Phase 4 | Completed | Novartis | 507 | 2004-11-01 | 2016-11-18 |
Hypertension (7) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Gout (1) · Kidney Diseases (1) · Masked Hypertension (1) · Metabolic Syndrome (1) · Obesity (1) · Overweight (1) · Prediabetic State (1) · Sleep Apnea, Obstructive (1)
Cardiovascular Diseases (14) · Vascular Diseases (14) · Metabolic Diseases (7) · Nutritional and Metabolic Diseases (7) · Glucose Metabolism Disorders (6) · Endocrine System Diseases (5) · Diabetes Mellitus (3) · Apnea (1) · Arthritis (1) · Body Weight (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Crystal Arthropathies (1) · Dyssomnias (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Nebivolol (3) · Amlodipine (2) · Metoprolol (2) · allisartan isoproxil (2) · Amiloride (1) · Ascorbic Acid (1) · BQ 788 (1) · Bradykinin (1) · Dietary Supplements (1) · Febuxostat (1) · Hydrochlorothiazide (1) · Olmesartan Medoxomil (1) · Sodium Chloride (1) · Sugars (1) · Valsartan (1)
University of California, San Diego (2) · University of Colorado, Boulder (2) · Augusta University (1) · Guangdong Provincial People's Hospital (1) · Kanokwan Bunsawat (1) · Novartis (1) · University of Alabama at Birmingham (1) · University of Guadalajara (1) · University of Roma La Sapienza (1) · University of Sao Paulo (1) · Virginia Polytechnic Institute and State University (1) · XueQing Yu (1)
United States (8) · Brazil (1) · China (1) · Italy (1) · Mexico (1)
Christopher A DeSouza, Ph.D. (1) · Christopher DeSouza, Ph.D. (1) · Daniel O'Connor, MD (1) · Daniel O'Connor, UCSD (1) · David A Calhoun, MD (1) · Francesco Pelliccia, MD (1) · Jason T. Davis, M.D. (1) · Jiyan Chen, MD (1) · Kanokwan Bunsawat, PHD (1) · Kevin P. Davy, Ph.D. (1) · Xueqing Yu, Doctor (1)
PMID 19120715, PMID 24410943, PMID 27113048, PMID 28447625, PMID 29122812, PMID 32877573