116 completed, 26 unknown, 13 active not recruiting, 13 recruiting. 140 Not applicable, 13 Phase 2, 7 Phase 1, 7 Phase 4, 5 Phase 3.
Follow Pre-diabetes: new trials by email Literature Review of Pre-diabetes trials Research Report on Pre-diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Point-of-care Capillary HbA1c Testing for Type 2 Diabetes Screening Among At-risk Individuals in Rural Dali, China POC-cHbA1c, Fingerstick RBG - Type 2 Diabetes, Pre-diabetes | Not applicable | Not yet recruiting | The University of Hong Kong | 720 | 2026-07-28 | 2026-07-28 |
| 7-Ketolithocholic Acid in Prediabetes 7-KLCA, Placebo, Diet and Physical Activity - Pre-diabetes | Not applicable | Recruiting | ICE S.p.A. | 100 | 2026-06-01 | 2026-06-16 |
| Milk for Diabetes Prevention Lactose-Containing Milk, Lactose-Free Milk - Lactose Intolerance, Lactose Intolerant | Not applicable | Recruiting | Albert Einstein College of Medicine | 40 | 2026-05-15 | 2026-05-26 |
| To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program - Cardiometabolic Conditions, Hypertension (HTN) | Not applicable | Enrolling by invitation | University of Hawaii | 400 | 2026-05-01 | 2026-06-09 |
| Evidence-based Intervention for Diabetes Prevention Adapted diabetes prevention program, App based support, Patient education materials - Pre-diabetes, Lifestyle Risk Reduction | Not applicable | Not yet recruiting | New York University | 30 | 2026-04-01 | 2026-03-02 |
| Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults Healthy Beef-Centric Diet, Healthy U.S.-Style Dietary Pattern - Metabolic Syndrome (MetS), Inflammation | Not applicable | Recruiting | National Cattlemen's Beef Association, a contractor to the Beef Checkoff | 56 | 2026-02-10 | 2026-08-31 |
| Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health Time-restricted eating (TRE) + Standard of Care, Standard of Care - Metabolic Syndrome, Pre-diabetes | Phase 2 | Recruiting | University of California, San Diego | 140 | 2025-10-23 | 2026-02-02 |
| Continuous Glucose Monitoring (CGM) in Prediabetes Continuous Glucose Monitoring - Pre-diabetes | Not applicable | Recruiting | SingHealth Polyclinics | 76 | 2025-10-16 | 2026-01-28 |
| The GRoceries Aimed at Increasing Nutrition Study Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives - Type 2 Diabetes, Type II Diabetes Mellitus | Not applicable | Active not recruiting | University of Pennsylvania | 219 | 2025-10-14 | 2026-10-20 |
| AI-Assisted Blood Glucose Management Study AI-based Lifestyle Management, Lifestyle Management - Pre-diabetes | Not applicable | Completed | Li Huating | 131 | 2025-09-07 | 2026-02-12 |
| More Health Less Diabetes Exercise - Pre-diabetes | Not applicable | Recruiting | Faculdade de Motricidade Humana | 90 | 2025-09-01 | 2025-07-23 |
| UK Islet Autoantibody Registry Type 1 Diabetes (T1D), Registry | Recruiting | University of Oxford | 350 | 2025-07-11 | 2025-08-15 | |
| CPAP and Glucose Metabolism in Non-Diabetic OSA Subjects CPAP - Obstructive Sleep Apnea, Pre-diabetes | Not applicable | Not yet recruiting | Woolcock Institute of Medical Research | 100 | 2025-07-01 | 2025-04-01 |
| OGTT at Home Using CGM vs at the Clinic OGTT at home using CGM, OGTT at the clinic - Pre-diabetes, Diabetes | Not applicable | Active not recruiting | Linkoeping University | 70 | 2025-06-11 | 2026-08-05 |
| VA|PREVENTION: Randomized Controlled Trial of a Person-Centred Digital Intervention to Prevent Diabetes in High-Risk Adults VA|PREVENTION web application (digital intervention), Type 2 Diabetes Guidebook - Pre-diabetes, Pre-diabetic State | Not applicable | Active not recruiting | Egas Moniz - Cooperativa de Ensino Superior, CRL | 180 | 2025-06-03 | 2026-02-19 |
| META Trial - a Mixed Methods Process Evaluation HIV, Pre-diabetes | Not yet recruiting | University College Dublin | 60 | 2025-06-01 | 2025-04-11 | |
| Effects of Milk Powder Intervention on Blood Glucose Control and Fluctuation in Middle-aged and Elderly People With Pre-diabetes fortified formula milk powder group, regular milk powder group - Pre-diabetes | Not applicable | Not yet recruiting | Huilian Zhu | 110 | 2025-04-10 | 2025-04-03 |
| Artificial Intelligence to Improve Cardiometabolic Risk Evaluation Using CT Scans Oral Glucose Tolerance Test - Pre-diabetes, Diabetes Mellitus | Not applicable | Not yet recruiting | Caristo Diagnostics Limited | 180 | 2025-02-15 | 2025-02-13 |
| Iowa Produce Prescription Program Iowa Produce Prescription Program (I-PPP), Produce Your Path Behavioral Nutrition Intervention (PYP) - Diabetes Mellitus Type 2, Pre-diabetes | Not applicable | Enrolling by invitation | Iowa State University | 300 | 2025-02-01 | 2025-05-01 |
| Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients Lumoral Treatment, Standard oral hygiene - Diabetes Mellitus, Type 2, Pre-diabetes | Not applicable | Recruiting | Wellbeing Services County of Pirkanmaa | 150 | 2025-01-23 | 2026-10-16 |
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Glucose Intolerance (190) · Diabetes Mellitus (45) · Diabetes Mellitus, Type 2 (42) · Obesity (42) · Insulin Resistance (24) · Metabolic Syndrome (22) · Overweight (13) · Hypertension (12) · Motor Activity (12) · Cardiovascular Diseases (5) · Dyslipidemias (5) · Prediabetic State (5) · Weight Loss (5) · Inflammation (4) · Glucose Metabolism Disorders (3)
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The University of Hong Kong (5) · Maastricht University Medical Center (4) · Clinical Nutrition Research Center, Illinois Institute of Technology (3) · Columbia University (3) · Indiana University (3) · University of Colorado, Denver (3) · University of Pennsylvania (3) · AdventHealth Translational Research Institute (2) · Albert Einstein College of Medicine (2) · DexCom, Inc. (2) · German Institute of Human Nutrition (2) · Icahn School of Medicine at Mount Sinai (2) · Johns Hopkins University (2) · Mayo Clinic (2) · Mike O'Callaghan Military Hospital (2)
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Dr Mandy Ho (2) · Jose A. Luchsinger, MD (2) · Joseph K Kaholokula, PhD (2) · Kieren J Mather, MD (2) · Nia Aitaoto, PhD (2) · Pam Taub, MD (2) · Paul Coen, PhD (2) · Robert R Henry, MD (2) · Adrian Vella, M.D. (1) · Adrian Vella, MD (1) · Adriana Lucia Mendes, PhD (1) · Aldo Torre, MD MSci (1) · Alexander Khoruts, MD (1)
PMID 33829034, PMID 15520847, PMID 17118995, PMID 17481469, PMID 17909087, PMID 18443133, PMID 19136406, PMID 19909549, PMID 20039889, PMID 20144387, PMID 20147680, PMID 20573788, PMID 20634174, PMID 20634175, PMID 20634176, PMID 21548959, PMID 22302620, PMID 22773702, PMID 22836068, PMID 22913890, PMID 22933432, PMID 23033239, PMID 23124047, PMID 23180210, PMID 23229846, PMID 23539736, PMID 23835684, PMID 24060673, PMID 24326527, PMID 24369008, PMID 24466598, PMID 24576395, PMID 24630390, PMID 25011019, PMID 25457793, PMID 25670921, PMID 26197707, PMID 26338891, PMID 26475629, PMID 26499966, PMID 26578409, PMID 26732017, PMID 26798647, PMID 26972954, PMID 27225217, PMID 27234480, PMID 27421729, PMID 28059466, PMID 28482070, PMID 28642810
OT2HL158287 (2), R01AG050440 (2), R01AT008310 (2), 2016 (1), 2019 (1), K01DK119166 (1), K23DK101692 (1), P20MD006882 (1), P30AG034546 (1), P30DK079626 (1), P50MD017338 (1), P50MD017342 (1), P50MD017344 (1), P60MD000206 (1), R01AG055299 (1)