38 completed, 21 recruiting, 12 not yet recruiting, 3 enrolling by invitation. 51 Not applicable, 14 Phase 2, 5 Phase 4, 4 Phase 1, 3 Early Phase 1.
Follow Posttraumatic Stress Disorder (PTSD): new trials by email Literature Review of Posttraumatic Stress Disorder (PTSD) trials Research Report on Posttraumatic Stress Disorder (PTSD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC tAN plus PEPC, sham plus PEPC - Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD) | Not applicable | Not yet recruiting | VA Office of Research and Development | 180 | 2027-01-01 | 2026-09-29 |
| EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder Written Exposure Therapy, Neutral Writing Condition - Posttraumatic Stress Disorder (PTSD) | Not applicable | Not yet recruiting | Mclean Hospital | 200 | 2027-01-01 | 2026-10-14 |
| Psilocybin-Assisted Psychotherapy for Veterans With PTSD Psilocybin-assisted Psychotherapy - Posttraumatic Stress Disorder (PTSD) | Phase 2 | Not yet recruiting | ARQ National Psychotrauma Centre | 12 | 2026-12-01 | 2026-08-28 |
| Predictors & Mechanisms of Adolescent PTSD Repeated imaginal exposure: Script Driven Imagery (SDI) task - Posttraumatic Stress Disorder (PTSD), Trauma Exposure | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 180 | 2026-11-01 | 2026-10-09 |
| MDMA-AT for PTSD in Young Adults With Childhood Trauma MDMA assisted psychotherapy - Posttraumatic Stress Disorder (PTSD) | Phase 2 | Not yet recruiting | Jenna M. Traynor | 15 | 2026-10-31 | 2026-08-20 |
| Post-traumatic Estradiol Administration and Care Evaluation (PEACE) 17β-estradiol, Placebo - Chronic Musculoskeletal Pain, Sexual Assault | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-09-28 | 2026-10-09 |
| Deep Brain Reorienting for Posttraumatic Stress Disorder Deep Brain Reorienting, Treatment as Usual (TAU) - Posttraumatic Stress Disorder (PTSD), Posttraumatic Stress Symptom | Not applicable | Recruiting | University of Alberta | 50 | 2026-09-21 | 2026-10-05 |
| Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial Written Exposure Therapy, Treatment as Usual - Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | Potomac Health Foundations | 400 | 2026-09-01 | 2026-08-24 |
| Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD CALM (Cognitive Apps for Life Management), Psychoeducation - Traumatic Brain Injury (TBI), Posttraumatic Stress Disorder (PTSD) | Not applicable | Recruiting | Duke University | 100 | 2026-08-04 | 2026-08-06 |
| The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy - Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD) | Phase 2 / Phase 3 | Recruiting | Coatesville VA Medical Center | 50 | 2026-08-01 | 2026-08-11 |
| Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD) Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Posttraumatic Stress Disorder (PTSD) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-08-01 | 2026-04-13 |
| Testing STAR and TextSTAR: A Randomized Controlled Trial Skills Training in Active Recovery (STAR) Video, Text Skills Training in Active Recovery (TextSTAR) program - Sexual Violence, Posttraumatic Stress Disorder (PTSD) | Not applicable | Enrolling by invitation | University of Wisconsin, Madison | 394 | 2026-06-25 | 2026-07-07 |
| Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits) Group Written Exposure Therapy - Posttraumatic Stress Disorder (PTSD), Borderline Personality Disorder (BPD) | Not applicable | Not yet recruiting | St. Joseph's Healthcare Hamilton | 63 | 2026-06-01 | 2026-05-08 |
| Examining Written Exposure Therapy Delivered to Adolescents Written Exposure Therapy, Trauma-focused Cognitive Behavior Therapy - Posttraumatic Stress Disorder (PTSD) | Not applicable | Active not recruiting | Medical University of South Carolina | 48 | 2026-05-06 | 2026-09-15 |
| Integrated Health Care for PTSD Yoga and meditation, Wellness, Positive affect - Posttraumatic Stress Disorder (PTSD) | Not applicable | Recruiting | Veterans Medical Research Foundation | 300 | 2026-04-23 | 2026-09-23 |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD Ketamine Infusion, Mindfulness-based cognitive therapy - Chronic Pain, Posttraumatic Stress Disorder (PTSD) | Phase 1 / Phase 2 | Recruiting | Dr. Yuliya Knyahnytska | 30 | 2026-03-31 | 2026-09-15 |
| To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Magnetic Stimulation Therapy for Patients With Post-traumatic Stress Disorder Comorbid Major Depressive Disorder Prolonged Intermittent Theta-Burst Stimulation (prolonged iTBS), High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS), Sham Transcranial Magnetic Stimulation - Posttraumatic Stress Disorder (PTSD), Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Tri-Service General Hospital (TSGH) | 50 | 2026-02-09 | 2026-02-17 |
| Metacognitive Therapy Compared to Cognitive-behavioral Therapy Transdiagnostic metacognitive therapy, Disorder-specific cognitive-behavioral therapy - Generalized Anxiety Disorder, Social Anxiety Disorder | Not applicable | Recruiting | Karolinska Institutet | 30 | 2026-01-28 | 2026-08-18 |
| Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD Cognitive Processing Therapy - Posttraumatic Stress Disorder (PTSD), Suicidal Ideation | Not applicable | Recruiting | Ohio State University | 190 | 2026-01-28 | 2026-02-24 |
| Two-week Intensive Outpatient Trauma Treatment. Prolonged exposure and EMDR - Posttraumatic Stress Disorder (PTSD) | Not applicable | Recruiting | Oslo University Hospital | 42 | 2026-01-26 | 2026-05-04 |
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Stress Disorders, Post-Traumatic (81) · Substance-Related Disorders (9) · Generalized Anxiety Disorder (6) · Alcoholism (5) · Anxiety Disorders (5) · Wounds and Injuries (5) · Depression (4) · Phobia, Social (4) · Opioid-Related Disorders (3) · Panic Disorder (3) · Psychological Well-Being (3) · Sleep Initiation and Maintenance Disorders (3) · Trauma and Stressor Related Disorders (3) · Bipolar Disorder (2) · Borderline Personality Disorder (2)
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Kathleen Thomaes, MD/PhD (2) · Lori Lynne Davis, MD AB (2) · Wen Li, PhD (2) · Yuval Neria, PhD (2) · Aaron D Fox, MD (1) · Adriana Feder, MD (1) · Alan L Peterson, PhD (1) · Alexandra Brazinova, prof. MD PhD (1) · Amani S Elbarazi, Ph.D. (1) · Amit Etkin, M.D., Ph.D. (1) · Andres Ort, MD (1) · Anna Woodbury, MD (1) · Aoife O'Donovan, PhD (1) · Benjamin Bohman (1) · Benjamin Hampstead, PhD (1)
PMID 31572236, PMID 33947471, PMID 22307881, PMID 24708195, PMID 25311446, PMID 26975521, PMID 27111751, PMID 27294447, PMID 27447948, PMID 27478057, PMID 28715907, PMID 28715908, PMID 29441152, PMID 29490371, PMID 29704183, PMID 30013726, PMID 30932508, PMID 30945920, PMID 31065731, PMID 32368793, PMID 32500209, PMID 32552778, PMID 32762677, PMID 33397139, PMID 33868050, PMID 33972795, PMID 34015141, PMID 34345377, PMID 36602803, PMID 37709999, PMID 38629403, PMID 38957149, PMID 39087734, PMID 39445615, PMID 40261043, PMID 42177712, PMID 42648713, PMID 42744153
2025 (2), R01MH132209 (2), K23DA055209 (1), K23MH141303 (1), R01MH132720 (1), R01MH135076 (1), R21MH102539 (1), R33DA059897 (1), R34MH078874 (1), R61DA059032 (1), ZIAMH002962 (1)