17 completed, 9 unknown, 7 recruiting, 5 terminated. 41 Phase 1, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 41 | Completed 17, Unknown 9, Recruiting 7, Terminated 5, Not yet recruiting 1, Suspended 1, Withdrawn 1 |
| Phase 2 | 10 | Unknown 3, Completed 2, Recruiting 2, Terminated 2, Suspended 1 |
Follow Pleural Diseases: new trials by email Literature Review of Pleural Diseases trials Research Report on Pleural Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Propranolol Treatment for Postoperative Chylothorax Propranolol Hydrochloride, Placebo - Postoperative Chylothorax, Congenital Heart Disease | Phase 1 / Phase 2 | Suspended | June Wu | 50 | 2025-09-09 | 2026-05-15 |
| A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197, Tube thoracostomy drainage - Malignant Pleural Effusions (Mpe) | Phase 1 | Recruiting | Jemincare | 30 | 2024-12-28 | 2025-04-04 |
| A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of OsrhCT in Patients With Pleurisy Recombinant Human Chymotrypsin(OsrhCT), Placebo for Recombinant Human Chymotrypsin(OsrhCT) - Pleurisy | Phase 1 | Unknown | Healthgen Biotechnology Corp. | 72 | 2024-07-01 | 2024-07-29 |
| A Study of MT027 in Patients with Pleural Malignant Tumors MT027 cells suspension - Advanced Malignant Solid Tumor, Malignant Pleural Effusion | Phase 1 | Recruiting | Suzhou Maximum Bio-tech Co., Ltd. | 18 | 2024-05-15 | 2024-12-10 |
| Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin Cytoreductive surgery, LMB-100, Immunohistochemical Assay for Mesothelin - Malignant Pleural Mesotheliomas (Mpm), Malignant Pleural Effusions (Mpe) | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2024-01-31 | 2024-02-02 | |
| Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer Tocilizumab - Malignant Pleural Effusion, Malignant Ascites | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 12 | 2024-01-30 | 2025-05-22 |
| OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. PITAC - Malignant Pleural Effusion, Pleural Neoplasms | Phase 1 | Unknown | Odense University Hospital | 20 | 2023-09-15 | 2024-05-20 |
| A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197 - Malignant Pleural Effusion | Phase 1 | Unknown | Jemincare | 78 | 2023-05-22 | 2023-06-28 |
| IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites IFN-γ and CIK cells, Tcm cells or CAR T cells - Pleural Effusion, Malignant | Phase 1 | Unknown | Affiliated Hospital of Jiangnan University | 40 | 2022-12-20 | 2024-05-16 |
| A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC M701 pleural infusion, Pleural drainage, Cisplatin pleural infusion - Malignant Pleural Effusions, NSCLC Stage IV | Phase 1 / Phase 2 | Recruiting | Wuhan YZY Biopharma Co., Ltd. | 116 | 2022-09-30 | 2026-07-08 |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease Porfimer Sodium, Video-Assisted Thoracic Surgery, Photodynamic Therapy - Lung Non-Small Cell Carcinoma, Pleural Disorder | Phase 1 | Terminated | Roswell Park Cancer Institute | 5 | 2022-03-10 | 2026-02-04 |
| Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery Light Dosimetry for Intranoperative Therapy, Photodynamic Therapy, Porfimer Sodium - Malignant Mesothelioma, Non-Small Cell Lung Carcinoma | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2021-09-17 | 2026-03-27 |
| A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion SCB-313 - Malignant Pleural Effusion | Phase 1 | Completed | Sichuan Clover Biopharmaceuticals, Inc. | 14 | 2020-01-08 | 2022-05-06 |
| Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions SCB-313 - Malignant Pleural Effusions | Phase 1 | Completed | Clover Biopharmaceuticals AUS Pty | 5 | 2019-11-20 | 2022-02-02 |
Showing 20 of 41. Sign in to see all of them.
Pleural Effusion, Malignant (33) · Carcinoma, Non-Small-Cell Lung (12) · Mesothelioma, Malignant (9) · Lung Neoplasms (8) · Breast Neoplasms (5) · Esophageal Neoplasms (5) · Neoplasm Metastasis (5) · Neoplasms (4) · Pleural Effusion (4) · Anus Neoplasms (3) · Bile Duct Neoplasms (3) · Breast Neoplasms, Male (3) · Carcinoma, Hepatocellular (3) · Carcinoma, Renal Cell (3) · Colonic Neoplasms (3)
Respiratory Tract Diseases (40) · Neoplasms by Site (37) · Respiratory Tract Neoplasms (36) · Thoracic Neoplasms (36) · Neoplasms (35) · Pleural Neoplasms (33) · Pleural Effusion (31) · Lung Diseases (21) · Lung Neoplasms (14) · Bronchial Neoplasms (13) · Neoplasms by Histologic Type (13) · Neoplasms, Glandular and Epithelial (13) · Adenoma (12) · Carcinoma, Bronchogenic (12)
Bevacizumab (3) · Carboplatin (3) · Photochemotherapy (3) · 1-phenyl-3,3-dimethyltriazene (2) · Dihematoporphyrin Ether (2) · Interleukin-2 (2) · Pharmaceutical Preparations (2) · Trastuzumab (2) · Trioxsalen (2) · aldesleukin (2) · 2-Propanol (1) · Afatinib (1) · Blood Specimen Collection (1) · Bortezomib (1) · Cisplatin (1)
National Cancer Institute (NCI) (5) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (2) · Jemincare (2) · Roswell Park Cancer Institute (2) · Abramson Cancer Center at Penn Medicine (1) · Affiliated Hospital of Jiangnan University (1) · Assiut University (1) · BioSyngen Pte Ltd (1) · Candel Therapeutics, Inc. (1) · Centre Hospitalier Universitaire Vaudois (1) · Clover Biopharmaceuticals AUS Pty (1) · David Bartlett, MD (1) · Gang Hou (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Hans Smit (1)
United States (20) · China (9) · Australia (2) · United Kingdom (2) · Denmark (1) · France (1) · Netherlands (1) · Nigeria (1) · Switzerland (1)
Patrick Wagner, MD (2) · Angela Davies (1) · Anthony W. Tolcher, MD (1) · Ben Creelan, M.D. (1) · Charu Aggarwal, MD (1) · Daniel H. Sterman, M.D. (1) · Daniel H. Sterman, MD (1) · David Bartlett, MD (1) · David E. Gerber, MD (1) · David R. Jones, MD (1) · David S Schrump, M.D. (1) · David S. Schrump, MD (1) · Feng Wang (1) · Gang Hou, PhD (1) · George Blumenschein, MD (1)
PMID 20068553, PMID 29550074, PMID 34905086, PMID 36028846, PMID 36875061, PMID 42448681
2014 (1), N01CM17101 (1), P01CA066726 (1), U01CA076576 (1)