29 completed, 3 recruiting, 3 unknown, 2 terminated. 29 Not applicable, 5 Phase 2, 3 Phase 1, 2 Early Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries Intrathecal Morphine, Intrathecal Dexmedetomidine, Normal Saline - Intrathecal Morphine, Intrathecal Dexmedetomidine | Not applicable | Recruiting | Tanta University | 90 | 2026-07-01 | 2026-08-20 |
| Effects of 8 Weeks of Turmeric Ingestion on Physiology and Wellbeing in Healthy Older Adults Raw turmeric shots, Placebo - Turmeric, Placebo | Not applicable | Completed | Nottingham Trent University | 90 | 2025-10-06 | 2026-10-19 |
| Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels Low-intensity TMS, Transcranial Magnetic Stimulation Sham - Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation | Phase 1 / Phase 2 | Recruiting | Universidad de Guanajuato | 40 | 2024-10-28 | 2025-05-08 |
| Caffeinated Chewing Gum on Special Forces Performance caffeine - Caffeine, Placebo | Not applicable | Completed | National Taiwan Sport University | 16 | 2024-10-05 | 2025-06-26 |
| Nitrate Formulations and Exercise Performance Nitrate - Nitrate, Nitrate/Citrulline | Not applicable | Completed | University of Greenwich | 15 | 2024-08-01 | 2025-03-27 |
| Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Females Beetroot juice combined with caffeine (COM), Beetroot juice placebo with caffeine (CAF), Beetroot juice with caffeine placebo (BRJ) - Beetroot Juice, Caffeine | Not applicable | Completed | Jose Manuel Jurado Castro | 15 | 2024-08-01 | 2025-01-06 |
| Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG) RelieVRx, Sham-VR, No-VR (natural history control) - Pain, Virtual Reality | Not applicable | Recruiting | University of Maryland, Baltimore | 78 | 2024-04-09 | 2026-07-07 |
| Caffeinated Chewing Gum on 400-meter Performance caffeine - Caffeine, Placebo | Not applicable | Completed | Chih-Hui Chiu | 19 | 2024-04-08 | 2024-08-06 |
| Caffeine & Bodybuilding Dehydration Ability caffeine - Caffeine, Placebo | Not applicable | Completed | Chih-Hui Chiu | 14 | 2024-04-08 | 2024-07-24 |
| Caffeinate Chewing Gum on Ice Hockey Performance caffeinate chewing gum - Caffeine, Placebo | Not applicable | Completed | National Taiwan Sport University | 14 | 2024-02-05 | 2024-08-16 |
| Naltrexone for Prolonged Grief Disorder Naltrexone Oral Product, Placebo - Naltrexone HCl 50 MG Oral Tablet, Placebo | Phase 4 | Terminated | Texas Tech University | 7 | 2023-08-01 | 2026-05-18 |
| Acute Caffeine Intake in Young vs Older Adults Caffeine, Placebo - Caffeine, Placebo | Not applicable | Completed | University of Alcala | 120 | 2023-01-14 | 2026-07-17 |
| Stimulating Brain Waves During Deep Sleep DREEM2, Placebo - Placebo, Experimental | Not applicable | Unknown | University of Ottawa | 110 | 2022-08-12 | 2022-08-16 |
| Suvorexant as an Adjunct to Buprenorphine in Persons Who Use Fentanyl Suvorexant, Placebo - Suvorexant, Placebo | Phase 2 | Completed | Johns Hopkins University | 76 | 2022-03-30 | 2026-08-10 |
| Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults beetroot juice - Dietary Supplement, Placebo | Not applicable | Completed | Universidad Francisco de Vitoria | 9 | 2022-03-01 | 2022-05-09 |
| Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 Diabetes Caffeine and glucose, Glucose alone, Placebo - Caffeine and Carbohydrate, Carbohydrate Only | Not applicable | Completed | Insel Gruppe AG, University Hospital Bern | 21 | 2022-02-04 | 2023-03-14 |
| Impact of Beetroot Juice Ingestion on Female Rugby Performance Beetroot juice - Nitric Oxide, Placebo | Not applicable | Completed | Universidad Francisco de Vitoria | 13 | 2022-01-20 | 2022-04-21 |
| Caffeine Supplementation Improves the Cognitive Abilities and Shooting Performance of Trained E-sports Players caffeine - Caffeine, Placebo | Not applicable | Completed | National Taiwan Sport University | 9 | 2022-01-01 | 2022-08-30 |
| Placebo Effects Investigated by Different Experimental Designs Caffeine, Placebo - Caffeine, Placebo | Not applicable | Unknown | University of Sao Paulo | 18 | 2022-01-01 | 2021-06-15 |
| Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences Naltrexone Hydrochloride, Placebo - Naltrexone, Placebo | Early Phase 1 | Completed | San Diego State University | 217 | 2021-11-16 | 2026-09-10 |
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Pain (4) · Motor Activity (2) · Temporomandibular Joint Disorders (2) · Depression (1) · Depressive Disorder, Major (1) · Diabetes Mellitus, Type 1 (1) · Feeding Behavior (1) · Hypoglycemia (1) · Idiopathic Hypersomnia (1) · Nociceptive Pain (1) · Opioid-Related Disorders (1) · Pain, Postoperative (1) · Sleep Initiation and Maintenance Disorders (1)
Neurologic Manifestations (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Behavior (4) · Mental Disorders (3) · Craniomandibular Disorders (2) · Dyssomnias (2) · Jaw Diseases (2) · Joint Diseases (2) · Mandibular Diseases (2) · Muscular Diseases (2) · Musculoskeletal Diseases (2) · Nervous System Diseases (2) · Pain (2) · Sleep Disorders, Intrinsic (2)
Caffeine (11) · Naloxone (2) · Sodium Chloride (2) · Sugars (2) · Administration, Oral (1) · Anticonvulsants (1) · Citrulline (1) · Control Groups (1) · Cycloserine (1) · Exercise (1) · Exergaming (1) · Glucose (1) · Haloperidol (1) · Hydrocortisone (1) · Levodopa (1)
Universidad Francisco de Vitoria (4) · National Taiwan Sport University (3) · University of Maryland, Baltimore (3) · Chih-Hui Chiu (2) · University of Sao Paulo (2) · Charite University, Berlin, Germany (1) · Hartford Hospital (1) · Harvard School of Public Health (HSPH) (1) · Insel Gruppe AG, University Hospital Bern (1) · Johns Hopkins University (1) · Jose Manuel Jurado Castro (1) · King's College London (1) · Loughborough University (1) · National Institute on Drug Abuse (NIDA) (1) · Nottingham Trent University (1)
United States (10) · Spain (8) · Taiwan (5) · United Kingdom (4) · Switzerland (3) · Brazil (2) · Canada (1) · Egypt (1) · Germany (1) · Mexico (1)
ChihHui Chiu, PhD (4) · Luana Colloca, MD/PhD/MS (2) · Andrew S Huhn, Ph.D. (1) · Carlos Ugrinowitsch, PhD (1) · Christoph Stettler, MD (1) · David H Epstein, Ph.D. (1) · Evgeny M Krupitsky, MD, PhD (1) · Fernando Naclerio (1) · Flavio O Pires, Phd (1) · Gretchen J. Diefenbach, Ph.D. (1)
PMID 12505794, PMID 16929307, PMID 20057930, PMID 22387929, PMID 27595147, PMID 30246799, PMID 32629197, PMID 34132880, PMID 34611208, PMID 36641027, PMID 38558517, PMID 38581746, PMID 38902928, PMID 40287780, PMID 42142184, PMID 42148901
R01DA052883 (1), R01MH076136 (1), UH3DA048734 (1)