40 completed, 9 unknown, 2 not yet recruiting, 1 terminated. 34 Phase 1, 5 Phase 2, 5 Phase 3, 4 Phase 4, 2 Not applicable.
Follow Pharmacodynamics: new trials by email Literature Review of Pharmacodynamics trials Research Report on Pharmacodynamics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients Sarcopenia, Frailty | Completed | Konya Meram State Hospital | 100 | 2026-05-13 | 2026-07-28 | |
| Comparison of the Pharmacokinetics (PK) and Pharmacodynamics (PD) Biosimilarity of Proposed Biosimilar/Interchangeable Rapid-Acting Insulin Aspart (I004) and NovoLog® After Single-Dose Subcutaneous Administration to Healthy Volunteers I004, NovoLog - Pharmacokinetics, Pharmacodynamics | Phase 2 / Phase 3 | Completed | Amphastar Pharmaceuticals, Inc. | 62 | 2026-04-06 | 2026-07-22 |
| Study of BB-025, Alone and After BB-031, in Healthy Volunteers BB-025, BB-031 - Pharmacodynamics, Pharmacokinetics | Phase 1 | Completed | Basking Biosciences, Inc. | 72 | 2025-11-05 | 2026-04-06 |
| Single Ascending Dose and Multiple Ascending Dose Study of AVR-48 AVR-48, Placebo - Safety Issues, Tolerability | Phase 1 | Not yet recruiting | AyuVis Research, Inc. | 48 | 2025-06-01 | 2025-04-06 |
| Reevaluation Prediction of the Effect Site Propofol Eleveld Model Using Slow and Fast Induction Evaluation of the prediction of from the propofol PKPD model including in TCI pumps using fast (Effect site mode TCI) or slow (plasma TCI mode) induction - Anesthesia for Elective Surgery Patients, Anesthesia Brain Monitor | Completed | Pablo O. Sepulveda | 70 | 2025-01-15 | 2025-11-19 | |
| KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts Atorvastatin - Pharmacodynamics | Phase 1 | Unknown | Mikko Niemi | 15 | 2024-04-20 | 2024-06-21 |
| Study to Evaluate Pharmacokinetic and Pharmacodynamic Drug Interactions and Safety of IY-NS250 and IY-NT-SR IY-NS250, IY-NT-SR - Pharmacokinetics, Pharmacodynamics | Phase 1 | Completed | Il-Yang Pharm. Co., Ltd. | 56 | 2024-01-30 | 2024-12-10 |
| Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience Kratom, Placebo - Safety, Pharmacokinetics | Phase 1 | Completed | Altasciences Company Inc. | 40 | 2023-08-16 | 2025-09-29 |
| SB17170 Phase1 Trial in Healthy Volunteer SB17170, Placebo - Safety Issues, Tolerability | Phase 1 | Completed | SPARK Biopharma | 64 | 2023-05-24 | 2024-03-21 |
| Electrophysiological Effects of Potential QT Prolonging Drugs Clarithromycin, Pimozide, Placebo (Part 1) - Drug-induced QT Prolongation, Pharmacokinetics | Phase 1 | Completed | Food and Drug Administration (FDA) | 44 | 2023-03-21 | 2023-06-22 |
| Imapct of bioMarkers on Pharmacodynamics and Bleeding Risk of Direct Oral AntiCoagulants and Ticagrelor Study II Detection of genotype and RNA profile in platelet and white blood cell, Indicators test related to coagulation function, Indicators test related to platelet function - Novel Oral Anticoagulants, NOACs | Not yet recruiting | Peking University First Hospital | 2000 | 2023-03-01 | 2023-03-10 | |
| Comparison of the Pharmacokinetics (PK) and Pharmacodynamics (PD) Biosimilarity of Proposed Biosimilar Rapid-Acting Insulin Aspart (I004) and NovoLog After Single-Dose Subcutaneous Administration to Healthy Volunteers I004, NovoLog - Pharmacokinetics, Pharmacodynamics | Phase 2 / Phase 3 | Completed | Amphastar Pharmaceuticals, Inc. | 69 | 2022-08-22 | 2026-03-05 |
| Double-blind, Randomized Comparative Cross-sectional Study of Pharmacodynamics and Pharmacokinetics of Drugs GP40141 GP40141, Nplate - Pharmacodynamics, Pharmacokinetics | Phase 1 | Unknown | Geropharm | 56 | 2022-06-03 | 2022-12-15 |
| Clinical Decision Support Tool for Vancomycin Dosing in Children Computer Decision Support Tool Intervention Group, Matched Historical Controls - Gram-Positive Bacterial Infections, Vancomycin | Not applicable | Completed | University of Maryland, Baltimore | 75 | 2022-05-09 | 2025-05-14 |
| Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers saline intravenous administration, oral water - Intravenous Fluids, Pharmacodynamics | Not applicable | Completed | Centre Hospitalier Universitaire, Amiens | 59 | 2021-11-30 | 2025-05-28 |
| Study of DTRI-031 in Healthy Volunteers DTRI-031, Placebo - Healthy Volunteers, Pharmacokinetics | Phase 1 | Completed | Basking Biosciences, Inc. | 46 | 2021-10-20 | 2022-07-19 |
| Pharmacodynamic Biomarkers to Support Biosimilar Development: Interferon Beta-1A Products Interferon beta-1a, Peginterferon beta-1a, Placebo - Healthy Subjects, Pharmacokinetics | Phase 1 | Completed | Food and Drug Administration (FDA) | 84 | 2020-02-28 | 2024-04-22 |
| Pharmacodynamic Biomarkers to Support Biosimilar Development: Interleukin-5 Antagonists Mepolizumab, Reslizumab, Placebo - Healthy Subjects, Pharmacokinetics | Phase 1 | Completed | Food and Drug Administration (FDA) | 72 | 2020-02-17 | 2024-04-22 |
| Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors Evolocumab, Alirocumab, Placebo - Healthy Subjects, Pharmacokinetics | Phase 1 | Completed | Food and Drug Administration (FDA) | 72 | 2020-01-07 | 2024-04-22 |
| Association of Cefepime Trough Levels With Clinical Efficacy and Neurotoxicity in Patients With Febrile Neutropenia Pharmacokinetics, Pharmacodynamics | Unknown | Universitaire Ziekenhuizen KU Leuven | 98 | 2019-08-01 | 2021-04-28 |
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Obesity (2) · Arthritis, Rheumatoid (1) · Breast Neoplasms (1) · Diabetes Mellitus (1) · Endometrial Neoplasms (1) · Erectile Dysfunction (1) · Febrile Neutropenia (1) · Frailty (1) · Gram-Positive Bacterial Infections (1) · Hemorrhage (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Ischemic Stroke (1) · Neurotoxicity Syndromes (1) · Ovarian Neoplasms (1) · Pediatric Obesity (1)
Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Nutritional and Metabolic Diseases (3) · Pathologic Processes (3) · Signs and Symptoms (3) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Body Weight (2) · Central Nervous System Diseases (2) · Endocrine System Diseases (2) · Genital Diseases (2) · Infections (2) · Nutrition Disorders (2) · Overnutrition (2) · Overweight (2)
Moxifloxacin (3) · Tablets (3) · ASP3652 (2) · Clopidogrel (2) · Diltiazem (2) · Eplerenone (2) · Esomeprazole (2) · Insulin Aspart (2) · Propofol (2) · dofetilide (2) · tegoprazan (2) · ACT-462206 (1) · Alfentanil (1) · Atorvastatin (1) · Chloroquine (1)
Food and Drug Administration (FDA) (6) · AstraZeneca (4) · Astellas Pharma Europe B.V. (3) · Ain Shams University (2) · Amphastar Pharmaceuticals, Inc. (2) · Basking Biosciences, Inc. (2) · Cui Yimin (2) · HK inno.N Corporation (2) · Il-Yang Pharm. Co., Ltd. (2) · Altasciences Company Inc. (1) · Astellas Pharma Inc (1) · AyuVis Research, Inc. (1) · Azidus Brasil (1) · Bayer (1) · Baylor College of Medicine (1)
United States (14) · China (5) · Netherlands (5) · South Korea (5) · Germany (4) · United Kingdom (4) · Australia (2) · Canada (2) · Egypt (2) · Finland (2) · France (2) · Belgium (1) · Chile (1) · Denmark (1) · Indonesia (1)
Carlos Sanabria, MD (3) · Chris Argent, MD (1) · Christopher D O'Brien, MD, PhD (1) · Colleen Nalepinski, MPAS, PA-C (1) · Gaetano Morelli, MD (1) · Gaia Schiavon, MSD (1) · Gerard Rongen, Prof. (1) · Huacheng Liu (1) · Igor Mr Makarenko, PhD (1) · In Jin Jang, MD, PhD (1)
PMID 22128200, PMID 23099620, PMID 23103177, PMID 25356826, PMID 25703312, PMID 26259627, PMID 28036330, PMID 28036334, PMID 29066505, PMID 30447156, PMID 32312891, PMID 32715381, PMID 33863913, PMID 34123370, PMID 34250397, PMID 35082514, PMID 35501592, PMID 35935625, PMID 36578040, PMID 37203300, PMID 37740581, PMID 38258274, PMID 39179443, PMID 41420638, PMID 41844879, PMID 42031608
2015 (2), 2004 (1), 2008 (1), T32HD087969 (1)