522 completed, 316 recruiting, 208 unknown, 116 active not recruiting. 441 Phase 2, 326 Phase 1, 309 Not applicable, 94 Phase 3, 24 Early Phase 1.
Follow this condition Literature Review of Endometrial Neoplasms trials Research Report on Endometrial Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain Biospecimen Collection, Low-Dose Aspirin, Patient Observation - Endometrial Carcinoma | Phase 4 | Not yet recruiting | Mayo Clinic | 20 | 2027-02-12 | 2026-08-05 |
| Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program - Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 48 | 2027-01-01 | 2026-10-01 |
| Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer Tirzepatide - Endometrial Cancer, Endometrial Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2027-01-01 | 2026-09-28 |
| Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer DEAR-Based Comprehensive Weight Management, Balanced Diet and Self-Directed Exercise - Endometrial Cancer | Not applicable | Not yet recruiting | Peking University People's Hospital | 160 | 2027-01-01 | 2026-10-16 |
| Development Of An Endometrial Cancer Educational Tool Interactive Educational Website - Endometrial Cancer | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-01-01 | 2026-07-31 |
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Elacestrant With Everolimus for the Treatment of Recurrent Advanced or Metastatic ER-Positive Endometrial Cancer Biospecimen Collection, Computed Tomography, Elacestrant - Advanced Endometrial Carcinoma, Metastatic Endometrial Carcinoma | Phase 2 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 50 | 2026-12-18 | 2026-06-09 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Plant-Based Nutrition for Breast or Endometrial Cancer Control, Whole Food, Plant-Based Diet with Behavioral Education and Support - Breast Cancer Metastatic, Endometrial Cancer Stage IV | Not applicable | Not yet recruiting | University of Rochester | 60 | 2026-12-01 | 2026-04-08 |
| Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial Imlunestrant, Abemaciclib, Selinexor - Low Grade Ovarian Serous Adenocarcinoma, Endometrial Cancer | Phase 2 | Not yet recruiting | Dana-Farber Cancer Institute | 60 | 2026-12-01 | 2026-09-21 |
| A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001) MK-6255, CD8 PET Tracer, Acetaminophen - Ovarian Neoplasms, Endometrial Neoplasms | Phase 1 | Not yet recruiting | Merck Sharp & Dohme LLC | 80 | 2026-11-13 | 2026-10-13 |
| Two Part (Phase1b/ Phase3) Trial of Subcutaneous Dostarlimab Plus Carboplatin-Paclitaxel in Participants With Primary Advanced or Recurrent Endometrial Cancer Dostarlimab, Carboplatin and paclitaxel - Endometrial Carcinoma, Neoplasms, Endometrial | Phase 3 | Not yet recruiting | GlaxoSmithKline | 378 | 2026-11-12 | 2026-10-19 |
| Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer Mazdutide(Dual GLP-1R/GCGR Agonist), Placebo, Levonorgestrel-releasing intrauterine system - Obesity, Overweight | Phase 2 | Not yet recruiting | Tongji Hospital | 128 | 2026-11-01 | 2026-08-24 |
| A Study to Evaluate the Safety,Pharmacokinetics,Pharmacodynamics,and Efficacy of TJ037130 in Adult Participants With Advanced Solid Tumors TJ037130 - Solid Tumor, Metastatic Ovary Cancer | Phase 1 | Recruiting | TJ Biopharma Co., Ltd. | 128 | 2026-10-30 | 2026-10-19 |
| MTX-531-001 Phase 1 Study in Advanced Solid Tumors MTX-531 - Solid Tumors (Phase 1), HNSCC | Phase 1 | Not yet recruiting | MEKanistic Therapeutics, Inc. | 71 | 2026-10-20 | 2026-10-15 |
| Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome Lynch Syndrome | Not yet recruiting | University of Edinburgh | 450 | 2026-10-16 | 2026-10-16 | |
| Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial Aerobic Exercise, Biospecimen Collection, Dietary Intervention - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 90 | 2026-10-10 | 2026-07-23 |
| Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer PF-08634404, Pembrolizumab, Standard of Care Chemotherapy - Endometrial Neoplasms, Endometrial Cancer | Phase 3 | Not yet recruiting | Pfizer | 600 | 2026-10-09 | 2026-10-08 |
| Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions Routine-care metastasis-directed radiotherapy - Cervical Cancer, Gynecologic Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-10-06 | 2026-10-20 | |
| Signatera Assessment in Early-Stage Endometrial Cancer Signatera Genome ultra-sensitive ctDNA blood test - Endometrial Cancer | Not applicable | Not yet recruiting | Natera, Inc. | 1010 | 2026-10-01 | 2026-06-17 |
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Ovarian Neoplasms (402) · Uterine Cervical Neoplasms (329) · Breast Neoplasms (214) · Neoplasms (145) · Carcinoma, Non-Small-Cell Lung (133) · Colorectal Neoplasms (125) · Stomach Neoplasms (123) · Fallopian Tube Neoplasms (109) · Prostatic Neoplasms (104) · Pancreatic Neoplasms (102) · Neoplasm Metastasis (90) · Melanoma (87) · Esophageal Neoplasms (82) · Urinary Bladder Neoplasms (79)
Female Urogenital Diseases (1414) · Female Urogenital Diseases and Pregnancy Complications (1414) · Urogenital Diseases (1414) · Genital Diseases (1412) · Genital Diseases, Female (1408) · Urogenital Neoplasms (1407) · Neoplasms by Site (1394) · Genital Neoplasms, Female (1391) · Uterine Diseases (1391) · Uterine Neoplasms (1341) · Neoplasms (1269) · Endocrine System Diseases (498) · Endocrine Gland Neoplasms (476) · Gonadal Disorders (473) · Adnexal Diseases (471)
Paclitaxel (99) · Carboplatin (83) · pembrolizumab (78) · Cisplatin (32) · Bevacizumab (27) · Surveys and Questionnaires (24) · Doxorubicin (23) · Letrozole (23) · Radiotherapy (22) · Specimen Handling (22) · Megestrol Acetate (20) · Magnetic Resonance Spectroscopy (19) · lenvatinib (19) · olaparib (19) · Docetaxel (18)
National Cancer Institute (NCI) (54) · M.D. Anderson Cancer Center (40) · Memorial Sloan Kettering Cancer Center (28) · Gynecologic Oncology Group (20) · Peking University People's Hospital (19) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (17) · Mayo Clinic (17) · UNC Lineberger Comprehensive Cancer Center (17) · AstraZeneca (16) · Dana-Farber Cancer Institute (14) · GlaxoSmithKline (13) · Merck Sharp & Dohme LLC (12) · Novartis Pharmaceuticals (11) · University of Oklahoma (11) · Asan Medical Center (10)
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Lei Li, M.D. (6) · Karen H. Lu, MD (5) · Pamela Soliman, MD (5) · Panagiotis Konstantinopoulos, MD, PhD (5) · Floor Backes, MD (4) · Kathleen Moore, MD (4) · Vicky Makker, MD (4) · Amit Oza (3)
PMID 36971688, PMID 40966692, PMID 35420695, PMID 38431043, PMID 15169803, PMID 19949018, PMID 21173649, PMID 21489874, PMID 22002018, PMID 22922531, PMID 23636398, PMID 26552419, PMID 27325856, PMID 35289396, PMID 3652025, PMID 37185961, PMID 37496366, PMID 40011116, PMID 40709601, PMID 40791544, PMID 41044356, PMID 41484629, PMID 42167105, PMID 11437723, PMID 11704843, PMID 11705489, PMID 11875733, PMID 12528778, PMID 12648575, PMID 12798713, PMID 12800205, PMID 12914829, PMID 12957454, PMID 14615449, PMID 15010069, PMID 15122083, PMID 15177491, PMID 15304161, PMID 15551359, PMID 15592836, PMID 15659504, PMID 15721401, PMID 15721421, PMID 15805295, PMID 15958000, PMID 15975638, PMID 15978659, PMID 16084259, PMID 16330675, PMID 16400639
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