523 completed, 323 recruiting, 206 unknown, 124 active not recruiting. 443 Phase 2, 329 Phase 1, 314 Not applicable, 94 Phase 3, 24 Early Phase 1.
Follow Endometrial Neoplasms: new trials by email Literature Review of Endometrial Neoplasms trials Research Report on Endometrial Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain Biospecimen Collection, Low-Dose Aspirin, Patient Observation - Endometrial Carcinoma | Phase 4 | Not yet recruiting | Mayo Clinic | 20 | 2027-02-12 | 2026-08-05 |
| Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program - Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 48 | 2027-01-01 | 2026-10-01 |
| Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer Tirzepatide - Endometrial Cancer, Endometrial Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2027-01-01 | 2026-09-28 |
| Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer DEAR-Based Comprehensive Weight Management, Balanced Diet and Self-Directed Exercise - Endometrial Cancer | Not applicable | Not yet recruiting | Peking University People's Hospital | 160 | 2027-01-01 | 2026-10-16 |
| Development Of An Endometrial Cancer Educational Tool Interactive Educational Website - Endometrial Cancer | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-01-01 | 2026-07-31 |
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Elacestrant With Everolimus for the Treatment of Recurrent Advanced or Metastatic ER-Positive Endometrial Cancer Biospecimen Collection, Computed Tomography, Elacestrant - Advanced Endometrial Carcinoma, Metastatic Endometrial Carcinoma | Phase 2 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 50 | 2026-12-18 | 2026-06-09 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Plant-Based Nutrition for Breast or Endometrial Cancer Control, Whole Food, Plant-Based Diet with Behavioral Education and Support - Breast Cancer Metastatic, Endometrial Cancer Stage IV | Not applicable | Not yet recruiting | University of Rochester | 60 | 2026-12-01 | 2026-04-08 |
| Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial Imlunestrant, Abemaciclib, Selinexor - Low Grade Ovarian Serous Adenocarcinoma, Endometrial Cancer | Phase 2 | Not yet recruiting | Dana-Farber Cancer Institute | 60 | 2026-12-01 | 2026-09-21 |
| Comparison of Superficial-Only Versus Combined Indocyanine Green Injection Techniques for Sentinel Lymph Node Mapping in Patients With Endometrial Cancer Superficial cervical ICG injection, Deep and superficial ICG cervical injection - Endometrial Cancer | Not applicable | Not yet recruiting | Barretos Cancer Hospital | 200 | 2026-12-01 | 2026-11-04 |
| A Study of LY4336619 in Adult Participants With Advanced Solid Tumors LY4336619, Sofetabart Mipitecan (Sofe-M) - Endometrial Neoplasms, Ovarian Neoplasms | Phase 1 | Not yet recruiting | Eli Lilly and Company | 370 | 2026-12-01 | 2026-11-10 |
| A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001) MK-6255, CD8 PET Tracer, Acetaminophen - Ovarian Neoplasms, Endometrial Neoplasms | Phase 1 | Not yet recruiting | Merck Sharp & Dohme LLC | 80 | 2026-11-13 | 2026-10-13 |
| Two Part (Phase1b/ Phase3) Trial of Subcutaneous Dostarlimab Plus Carboplatin-Paclitaxel in Participants With Primary Advanced or Recurrent Endometrial Cancer Dostarlimab, Carboplatin and paclitaxel - Endometrial Carcinoma, Neoplasms, Endometrial | Phase 3 | Not yet recruiting | GlaxoSmithKline | 378 | 2026-11-12 | 2026-10-19 |
| Gut Microbiome in Patients With Lung and Melanoma Cancer and Intestinal Microbiota in Gynecologic Cancers sample collection - Non Small Cell Lung Cancer, Melanoma (Skin Cancer) | Not applicable | Not yet recruiting | European Institute of Oncology | 360 | 2026-11-11 | 2026-11-04 |
| Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer Mazdutide(Dual GLP-1R/GCGR Agonist), Placebo, Levonorgestrel-releasing intrauterine system - Obesity, Overweight | Phase 2 | Not yet recruiting | Tongji Hospital | 128 | 2026-11-01 | 2026-08-24 |
| Adaptive Radiotherapy for Safe Hypofractionation Adaptive Hypofractionated Radiotherapy, Standard-of-care Radiotherapy - Cancer, Endometrial Cancer | Phase 2 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 264 | 2026-11-01 | 2026-10-29 |
| CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors CR-002 - Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ | Phase 1 / Phase 2 | Recruiting | Crescent Biopharma, Inc. | 219 | 2026-10-21 | 2026-11-02 |
| MTX-531-001 Phase 1 Study in Advanced Solid Tumors MTX-531 - Solid Tumors (Phase 1), HNSCC | Phase 1 | Not yet recruiting | MEKanistic Therapeutics, Inc. | 71 | 2026-10-20 | 2026-10-15 |
| Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic STRO-006, Pembrolizumab - Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Sutro Biopharma, Inc. | 285 | 2026-10-19 | 2026-10-23 |
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Ovarian Neoplasms (407) · Uterine Cervical Neoplasms (331) · Breast Neoplasms (214) · Neoplasms (145) · Carcinoma, Non-Small-Cell Lung (135) · Colorectal Neoplasms (125) · Stomach Neoplasms (124) · Fallopian Tube Neoplasms (109) · Prostatic Neoplasms (104) · Pancreatic Neoplasms (102) · Neoplasm Metastasis (91) · Melanoma (87) · Esophageal Neoplasms (82) · Urinary Bladder Neoplasms (79)
Female Urogenital Diseases (1425) · Female Urogenital Diseases and Pregnancy Complications (1425) · Urogenital Diseases (1425) · Genital Diseases (1423) · Genital Diseases, Female (1419) · Urogenital Neoplasms (1418) · Neoplasms by Site (1405) · Genital Neoplasms, Female (1402) · Uterine Diseases (1402) · Uterine Neoplasms (1350) · Neoplasms (1280) · Endocrine System Diseases (503) · Endocrine Gland Neoplasms (481) · Gonadal Disorders (478) · Adnexal Diseases (476)
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