14 completed, 4 recruiting, 2 not yet recruiting, 1 terminated. 6 Not applicable, 4 Phase 2, 2 Early Phase 1, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 6 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Terminated 1 |
| Early Phase 1 | 2 | Recruiting 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Not yet recruiting 1 |
Follow Perinatal Asphyxia: new trials by email Literature Review of Perinatal Asphyxia trials Research Report on Perinatal Asphyxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 310 | 2026-09-16 | 2026-08-13 | |
| Optimization of Routine Obstetric and Neonatal Care in the Management of Severe Perinatal Asphyxia in Term or Near-term Newborns: Analysis of Sub-optimal Care Perinatal Asphyxia | Recruiting | Assistance Publique - Hôpitaux de Paris | 336 | 2025-05-05 | 2026-07-01 | |
| Intranasal Breast Milk Therapy in HIE Intranasal breast milk - Hypoxic-Ischaemic Encephalopathy, Neonatal Encephalopathy | Early Phase 1 | Recruiting | Semmelweis University | 80 | 2025-02-01 | 2024-12-24 |
| Feasibility and Safety of Intranasally Administered Breast Milk in HIE Intranasal breast milk - Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischemic Encephalopathy of Newborn | Early Phase 1 | Recruiting | Semmelweis University | 10 | 2024-11-22 | 2025-05-22 |
| Quantification of Brain and Kidney Perfusion Before, During, and After Hypothermia Treatment in Neonates With Perinatal Asphyxia Using Contrast-enhanced Ultrasound Contrast enhanced ultrasound imaging (CEUS) and post processing with ULM - Perinatal Asphyxia, Hypothermia Treatment | Recruiting | University of Erlangen-Nürnberg Medical School | 20 | 2024-06-24 | 2024-09-24 | |
| Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns Infant, Premature - Preterm Birth, Low Birth Weight | Completed | HOSPITAL GINECO OBSTETRICO ISIDRO AYORA | 26000 | 2023-11-12 | 2024-10-22 | |
| Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings Fetal Distress, Perinatal Asphyxia | Completed | NICHD Global Network for Women's and Children's Health | 1017 | 2023-05-16 | 2024-05-07 | |
| Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement Augmented Infant Resuscitator (AIR) - Asphyxia Neonatorum, Birth Asphyxia | Not applicable | Completed | Massachusetts General Hospital | 250 | 2023-02-01 | 2025-11-20 |
| Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation Umbilical cord milking, Immediate cord clamping - Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not applicable | Completed | Lady Hardinge Medical College | 200 | 2022-02-05 | 2024-07-09 |
| Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia Non-Nutritive Sucking - Swallowing Disorder, Perinatal Asphyxia | Not applicable | Completed | Medipol University | 100 | 2021-11-01 | 2023-10-06 |
| Evaluation of Haemodynamic in Neonates Treated With Hypothermia" Hypothermia Neonatal, Haemodynamic Instability | Completed | Princess Anna Mazowiecka Hospital, Warsaw, Poland | 113 | 2021-08-01 | 2025-12-03 | |
| Determination of Heart Rate in Infants Needing Resuscitation at Birth Heart rate assessment (stethoscope), Heart assessment (umbilical cord palpation) - Perinatal Asphyxia | Not applicable | Completed | University Hospital Padova | 60 | 2019-02-25 | 2019-10-31 |
| Augmented Infant Resuscitator to Enhance Newborn Ventilation Augmented Infant Resuscitator (AIR), AIR device without feedback - Asphyxia Neonatorum, Birth Asphyxia | Not applicable | Completed | Massachusetts General Hospital | 270 | 2016-07-01 | 2021-03-29 |
| Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2 5% carbon-dioxide inhalation - Hypoxic-Ischaemic Encephalopathy, Perinatal Asphyxia | Phase 1 | Completed | Semmelweis University | 10 | 2016-02-01 | 2021-04-26 |
| Outcome After 24 Months of Participants in the TOBY Xenon Study Xenon - Perinatal Asphyxia, Encephalopathy | Completed | Guy's and St Thomas' NHS Foundation Trust | 69 | 2014-08-01 | 2019-05-30 | |
| Neuroprotective Role of Erythropoietin in Perinatal Asphyxia Erythropoietin - Perinatal Asphyxia | Phase 2 / Phase 3 | Completed | Sheri Kashmir Institute of Medical Sciences | 100 | 2012-06-01 | 2016-10-14 |
| A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia 2-Iminobiotin - Perinatal Asphyxia | Phase 2 | Terminated | Neurophyxia B.V. | 6 | 2012-06-01 | 2017-05-25 |
| Melatonin for Neuroprotection Following Perinatal Asphyxia Melatonin - Perinatal Asphyxia | Phase 1 / Phase 2 | Completed | Tanta University | 45 | 2012-01-01 | 2014-02-25 |
| Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy Ascorbic acid (vitamin C), Ibuprofen, Placebo - Hypoxic Ischemic Encephalopathy, Perinatal Asphyxia | Not applicable | Completed | Al-Azhar University | 60 | 2004-04-01 | 2008-02-28 |
Showing 20 of 21. Sign in to see all of them.
Hypoxia-Ischemia, Brain (9) · Asphyxia Neonatorum (5) · Brain Diseases (2) · Congenital Abnormalities (2) · Abruptio Placentae (1) · Brain Injuries (1) · Communication Disorders (1) · Deglutition Disorders (1) · Diabetes, Gestational (1) · Fetal Distress (1) · Fetal Growth Retardation (1) · Fetal Membranes, Premature Rupture (1) · Hypertension, Pregnancy-Induced (1) · Hypocapnia (1) · Hypoglycemia (1)
Pathological Conditions, Signs and Symptoms (12) · Central Nervous System Diseases (11) · Nervous System Diseases (11) · Signs and Symptoms (11) · Cardiovascular Diseases (10) · Vascular Diseases (10) · Brain Diseases (9) · Brain Ischemia (9) · Cerebrovascular Disorders (9) · Hypoxia (9) · Hypoxia, Brain (9) · Signs and Symptoms, Respiratory (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Infant, Newborn, Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (3)
2-iminobiotin (1) · Ascorbic Acid (1) · Erythropoietin (1) · Ibuprofen (1) · Melatonin (1) · Stethoscopes (1) · Umbilical Cord Clamping (1) · Xenon (1)
Semmelweis University (3) · Assistance Publique - Hôpitaux de Paris (2) · Massachusetts General Hospital (2) · Al-Azhar University (1) · Guy's and St Thomas' NHS Foundation Trust (1) · HOSPITAL GINECO OBSTETRICO ISIDRO AYORA (1) · Lady Hardinge Medical College (1) · Medipol University (1) · NICHD Global Network for Women's and Children's Health (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Neurophyxia B.V. (1) · Princess Anna Mazowiecka Hospital, Warsaw, Poland (1) · Sheri Kashmir Institute of Medical Sciences (1) · Tanta University (1) · UMC Utrecht (1)
Hungary (3) · Egypt (2) · India (2) · Turkey (Türkiye) (2) · United States (2) · Ecuador (1) · Ethiopia (1) · France (1) · Germany (1) · Italy (1) · Poland (1) · United Kingdom (1) · Zambia (1)
Unoke Meder, MD, PhD (2) · Ahmed Elsayed, MD (1) · Brett D. Nelson, MD, MPH (1) · David A Edwards, FMedSci (1) · Elwyn Chomba, MD (1) · Ferdinand Knieling, MD (1) · Feroz Shaheen, MD (1) · Gregor Hanslik, MD (1) · Heba Mahdy, MD (1) · Laila Abd-Rabboh, MD (1) · Paul Leufkens, PharmD (1) · Prof. WAjid Ali (1)
PMID 12915821, PMID 12928093, PMID 16185304, PMID 16786412, PMID 16819375, PMID 16860132, PMID 28863023, PMID 32000740, PMID 32222255, PMID 37144150, PMID 37873596, PMID 40617609
2025 (1), R03DK061502 (1)