27 completed. 27 Phase 2, 8 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 27 | Completed 27 |
| Phase 1 | 8 | Completed 8 |
| Phase 3 | 2 | Completed 2 |
Follow Paranasal Sinus Diseases: new trials by email Literature Review of Paranasal Sinus Diseases trials Research Report on Paranasal Sinus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis Nitric Oxide Releasing Solution, Nasal spray with isotonic saline - Recurrent Acute Rhinosinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 162 | 2024-01-16 | 2026-04-22 |
| A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. 300mg of TQH2722 injection, 600mg of TQH2722 injection, TQH2722 injection matching placebo - Sinusitis | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 160 | 2023-12-28 | 2026-11-10 |
| A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps Verekitug (UPB-101), Placebo - Chronic Rhinosinusitis With Nasal Polyps | Phase 2 | Completed | Upstream Bio Inc. | 81 | 2023-12-18 | 2026-09-18 |
| Dupilumab in CRSsNP Dupilumab SAR231893, Placebo - Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis | Phase 2 | Completed | Sanofi | 71 | 2020-12-02 | 2026-07-30 |
| Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) dupilumab, placebo - Chronic Sinusitis | Phase 2 | Completed | Johns Hopkins University | 33 | 2020-10-15 | 2025-11-03 |
| Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS) Nitric Oxide, Budesonide - Chronic Sinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 56 | 2019-10-27 | 2022-06-30 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Cisplatin, Adjuvant Proton Radiotherapy, Endoscopic Resection - Paranasal Sinus Cancer, Nasal Cavity Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 3 | 2017-09-01 | 2025-05-16 |
| SynRinse Irrigation Pilot (SIP) Trial Synrinse - Sinusitis, Chronic, Cystic Fibrosis With Other Manifestations | Phase 1 / Phase 2 | Completed | University of Washington | 30 | 2017-06-06 | 2018-10-17 |
| Adaptive Radiotherapy for Head and Neck Cancer Adaptive Radiotherapy - Head and Neck Cancer, Paranasal Sinus Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 64 | 2017-03-15 | 2021-10-26 |
| The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis Silver Colloid, Saline - Rhinosinusitis | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 22 | 2015-12-10 | 2019-11-15 |
| Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis Budesonide - Rhinosinusitis | Phase 1 / Phase 2 | Completed | Pari Pharma GmbH | 19 | 2015-10-27 | 2022-04-12 |
| Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia dexpramipexole - Chronic Sinusitis With Nasal Polyps and Eosinophilia | Phase 2 | Completed | Knopp Biosciences | 20 | 2014-08-01 | 2021-05-18 |
| Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi Budesonide - Rhinosinusitis, Chronic Polyposis | Phase 1 / Phase 2 | Completed | Pari Pharma GmbH | 14 | 2013-08-28 | 2022-04-12 |
| Evaluation of Inhaled Treatment in Sinusitis methylprednisolone, Budesonide - Sinusitis | Phase 2 / Phase 3 | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 50 | 2013-07-01 | 2014-01-27 |
| Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial placebo, doxycycline 100 mg - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 | Completed | University Hospital, Ghent | 33 | 2011-11-22 | 2018-06-15 |
| Manuka Honey Irrigation After Sinus Surgery Manuka Honey, Saline Irrigation - Sinusitis | Phase 1 / Phase 2 | Completed | St. Paul's Hospital, Canada | 78 | 2011-06-01 | 2013-12-04 |
| Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge Bacitracin - Paranasal Sinus Disease | Phase 2 | Completed | Steward St. Elizabeth's Medical Center of Boston, Inc. | 226 | 2010-07-01 | 2017-05-31 |
| Theophylline in Rhinitis Theophylline (Intervention Group), Placebo (Placebo Group) - Rhinosinusitis, Asthma | Phase 2 | Completed | University of East Anglia | 28 | 2010-05-01 | 2012-08-23 |
| Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis FFNS 110 mcg QD, FFNS 110 mcg BID, Placebo Nasal Spray - Sinusitis, Acute | Phase 2 | Completed | GlaxoSmithKline | 741 | 2010-01-06 | 2017-05-17 |
Showing 20 of 27. Sign in to see all of them.
Sinusitis (15) · Rhinosinusitis (9) · Paranasal Sinus Neoplasms (5) · Laryngeal Neoplasms (4) · Head and Neck Neoplasms (3) · Nasal Polyps (3) · Asthma (2) · Bronchiolitis Obliterans Syndrome (2) · Hypopharyngeal Neoplasms (2) · Mouth Neoplasms (2) · Nasopharyngeal Neoplasms (2) · Oropharyngeal Neoplasms (2) · Pharyngeal Neoplasms (2) · Adenocarcinoma (1)
Nose Diseases (26) · Otorhinolaryngologic Diseases (26) · Respiratory Tract Diseases (26) · Infections (21) · Respiratory Tract Infections (21) · Rhinitis (9) · Sinusitis (6) · Lung Diseases (5) · Neoplasms (5) · Neoplasms by Site (5) · Otorhinolaryngologic Neoplasms (5) · Respiratory Tract Neoplasms (5) · Bronchial Diseases (4) · Immune System Diseases (4)
Budesonide (4) · Sodium Chloride (2) · dupilumab (2) · Azithromycin (1) · BID protein, human (1) · Bacitracin (1) · Blood Specimen Collection (1) · Celecoxib (1) · Cetuximab (1) · Chemoprevention (1) · Cisplatin (1) · Dexpramipexole (1) · Doxycycline (1) · Endoscopic Mucosal Resection (1) · Erlotinib Hydrochloride (1)
Johnny Kao (2) · Memorial Sloan Kettering Cancer Center (2) · Pari Pharma GmbH (2) · Sanotize Research and Development corp. (2) · Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Entellus Medical, Inc. (1) · GlaxoSmithKline (1) · HaEmek Medical Center, Israel (1) · Johns Hopkins University (1) · Knopp Biosciences (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Ochsner Health System (1) · Ohio State University Comprehensive Cancer Center (1) · Pfizer (1)
United States (15) · Canada (6) · Germany (5) · Spain (3) · Belgium (2) · China (2) · Czechia (2) · Poland (2) · Russia (2) · Sweden (2) · Ukraine (2) · Argentina (1) · Bulgaria (1) · Chile (1) · Estonia (1)
Amin Javer, MD (1) · Amin R Javer, MD, FRCSC (1) · Amit Agrawal (1) · Andrew M Wilson (1) · C. Jillian Tsai, MD (1) · Claus Bachert, MD, PhD (1) · Coralie Colbrant, PT (1) · Greg Davis, MD (1) · Gregory Reychler, PhD (1) · James Stankiewicz, MD (1) · Jody Tversky (1) · Johnny Kao, M.D. (1) · Johnny Kao, MD (1)
PMID 15023840, PMID 15125017, PMID 15316237, PMID 15510034, PMID 17405780, PMID 17882910, PMID 19419611, PMID 19559969, PMID 19794023, PMID 20830768, PMID 21246519, PMID 21994147, PMID 23378777, PMID 23785241, PMID 27394715, PMID 28390807, PMID 29178954, PMID 33735508, PMID 39393433, PMID 8281565, PMID 9755259
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