19 completed, 6 active not recruiting, 5 not yet recruiting, 3 unknown. 21 Not applicable, 3 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Completed 10, Active not recruiting 6, Not yet recruiting 3, Unknown 2 |
| Phase 4 | 3 | Completed 3 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Permanent Supportive Housing Overdose Prevention+ Study TA Intervention - Overdose, Substance Use | Not applicable | Not yet recruiting | NYU Langone Health | 2940 | 2027-07-01 | 2026-05-06 |
| The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study Community Paramedic Standard of Care (CP SOC), CROSSROADS - Opioid Use Disorder, Overdose, Drug | Not applicable | Not yet recruiting | Duke University | 400 | 2027-02-01 | 2026-10-14 |
| Disease Intervention Specialist (DIS) for SUD Substance Use Disorder (SUD), Opioid Use Disorder | Not yet recruiting | Ohio State University | 1200 | 2026-12-01 | 2026-10-15 | |
| A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3 Brief youth overdose prevention education, Usual Standard of Care - Overdose | Not applicable | Not yet recruiting | Boston Medical Center | 648 | 2026-11-01 | 2026-10-01 |
| Overdose Prevention Centers and Behavioral Health Overdose | Not yet recruiting | NYU Langone Health | 500 | 2026-09-01 | 2026-03-02 | |
| A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Brief youth overdose prevention education, Information about Naloxone, Usual standard of care - Overdose | Not applicable | Active not recruiting | Boston Medical Center | 22 | 2025-08-25 | 2026-08-07 |
| Shelter HArm Reduction Evaluation Overdose, Harm Reduction | Recruiting | NYU Langone Health | 80 | 2025-07-23 | 2026-08-25 | |
| Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose MI-CHANCE (TS + FTIR + MI), TS + FTIR + Flu and Hepatitis A Education - Overdose | Not applicable | Active not recruiting | University of California, San Diego | 588 | 2025-03-03 | 2026-04-06 |
| Home Safety Intervention household safety intervention - Suicide, Firearm Injury | Not applicable | Completed | VA Office of Research and Development | 40 | 2024-10-08 | 2026-08-28 |
| Emergency Medicine Peer Outreach Worker Engagement for Recovery Substance Misuse Assistance Response Team (SMART), Usual Care Group - Substance Use Disorders, Overdose | Recruiting | University of California, Los Angeles | 400 | 2024-07-01 | 2025-10-06 | |
| The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City Ganchero intervention - HIV Infections, HCV | Not applicable | Active not recruiting | North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI) | 69 | 2024-05-01 | 2026-07-24 |
| Permanent Supportive Housing Overdose Prevention CSH-Delivered Overdose Prevention Support - Overdose | Not applicable | Active not recruiting | NYU Langone Health | 1350 | 2023-09-26 | 2026-05-05 |
| Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone) Naloxone, Usual intervention - Overdose, Implementation as Usual | Not applicable | Active not recruiting | RTI International | 31 | 2023-07-01 | 2026-10-20 |
| Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD) Pharmacist Narcan Training, BIRT, SMC - Opioid Use Disorder, Overdose | Not applicable | Completed | University of Arkansas | 267 | 2023-05-05 | 2026-04-06 |
| Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opioid Dependence - Evaluation of a System Enabling a Large Expansion of Treatment Providers and Treatment Access Opioid maintenance treatment - Opioid Dependence, Overdose | Unknown | Region Skane | 2500 | 2023-01-31 | 2023-01-10 | |
| Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting Efficacy Activated Charcoal - Overdose | Phase 4 | Completed | State University of New York - Upstate Medical University | 5 | 2023-01-04 | 2024-05-30 |
| Smartphone Intervention for Overdose and COVID-19 iThrive WI Intervention - Substance Use Disorders, Overdose | Not applicable | Completed | University of Wisconsin, Madison | 60 | 2022-12-19 | 2024-12-05 |
| Community-based Education, Navigation, and Support Intervention for Military Veterans Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation - Overdose, Opioid Use Disorder | Not applicable | Active not recruiting | New York University | 300 | 2022-10-21 | 2026-06-03 |
| Evaluation of a Medication Health Center to Promote Opioid Safety MHC Outreach Intervention - Overdose | Not applicable | Unknown | Kaiser Permanente | 14 | 2022-06-15 | 2024-06-14 |
| Emergency Room Firearm and Medication Safety Intervention Suicide, Firearm Injury | Completed | VA Office of Research and Development | 28 | 2021-07-01 | 2024-08-13 |
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Drug Overdose (35) · Opioid-Related Disorders (11) · Substance-Related Disorders (10) · Risk-Taking (3) · Alcoholism (2) · HIV Infections (2) · Harm Reduction (2) · Suicide (2) · Adjustment Disorders (1) · Anxiety Disorders (1) · COVID-19 (1) · Depressive Disorder (1) · Emergencies (1) · Phobia, Social (1) · Self-Injurious Behavior (1)
Chemically-Induced Disorders (35) · Drug Misuse (35) · Mental Disorders (35) · Prescription Drug Misuse (35) · Substance-Related Disorders (25) · Narcotic-Related Disorders (11) · Behavior (8) · Behavioral Symptoms (3) · Infections (3) · RNA Virus Infections (3) · Virus Diseases (3) · Alcohol-Related Disorders (2) · Blood-Borne Infections (2) · Communicable Diseases (2) · Genital Diseases (2)
Naloxone (3) · Acetaminophen (1) · Acetylcysteine (1) · Anti-Bacterial Agents (1) · Anti-Infective Agents (1) · Benzodiazepines (1) · Buprenorphine, Naloxone Drug Combination (1) · Charcoal (1) · Educational Status (1) · Expectorants (1) · Hypolipidemic Agents (1) · Ibuprofen (1) · Influenza Vaccines (1) · Injections, Intramuscular (1) · Motivational Interviewing (1)
Kaiser Permanente (4) · NYU Langone Health (4) · Boston Medical Center (2) · University of Cincinnati (2) · VA Office of Research and Development (2) · Duke University (1) · Hennepin Healthcare Research Institute (1) · Indiana University (1) · Johns Hopkins Bloomberg School of Public Health (1) · Momentum Data (1) · New York University (1) · North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI) (1) · Norwegian University of Science and Technology (1) · Ohio State University (1) · RTI International (1)
United States (29) · United Kingdom (2) · Canada (1) · Norway (1) · Spain (1) · Sweden (1)
Ingrid Binswanger, MD (3) · Jason Glanz, PhD (3) · Amy Yule, MD (2) · Joseph A Simonetti, MD MPH (2) · Theresa Winhusen, PhD (2) · Alasdair J Gray (1) · Alexander S Bennett, PhD (1) · Andrew McGovern, MD (1) · Arne K Skulberg, MD PhD (1) · Bennett Allen, PhD (1) · Bennett Allen, PhD, MPA (1) · Carl A. Latkin, PhD (1) · Dennis P Watson, PhD (1) · Elizabeth Samuels, MD, MPH, MHS (1)
PMID 23556549, PMID 24290406, PMID 27004905, PMID 30837247, PMID 31722937, PMID 33184084, PMID 34009877, PMID 34223388, PMID 35132556, PMID 35137493, PMID 37287026, PMID 38258819, PMID 39421268, PMID 40560908, PMID 40737120, PMID 41029610, PMID 41316389
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