19 completed, 3 unknown, 2 recruiting, 1 not yet recruiting. 27 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 27 | Completed 19, Unknown 3, Recruiting 2, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
Follow Otitis: new trials by email Literature Review of Otitis trials Research Report on Otitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children Amoxicillin, Amoxicillin + Clavulanate, Placebo - Acute Otitis Media, AOM - Acute Otitis Media | Phase 4 | Not yet recruiting | Kuopio University Hospital | 219 | 2026-11-01 | 2026-10-16 |
| Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media) Amoxicillin, Amoxicillin-Clavulanate, Amoxicillin Placebo - Acute Otitis Media (AOM) | Phase 4 | Recruiting | Nader Shaikh | 1100 | 2026-10-01 | 2026-10-20 |
| Omega-3-Based Nutraceutical Supplementation as Adjunctive Therapy in Adults With Otitis Media With Effusion: A Multicenter, Double-Blind, Randomized Placebo-Controlled Trial Omega-3-based nutraceutical combination (Otoair Flogo), Bilastine 20 mg, Placebo Tablet or Capsule - Otits Media With Effusion | Phase 4 | Completed | Isola Tiberina - Gemelli Isola Hospital, Rome, Italy | 501 | 2025-10-01 | 2026-07-23 |
| Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study) Amoxicillin-Clavulanic acid 600mg - 42.9 mg/ 5 mL oral suspension, Saccharomyces boulardii CNCM I-745 - Antibiotic Associated Diarrhea, Acute Otitis Media | Phase 4 | Completed | Eskisehir Osmangazi University | 100 | 2025-08-01 | 2026-09-11 |
| Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections Trimethoprim Sulfamethoxazole - Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute | Phase 4 | Recruiting | Indiana University | 100 | 2025-05-20 | 2026-07-29 |
| Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Otitis Media in India Augmentin (ES)-600 - Otitis Media, Infections, Respiratory Tract | Phase 4 | Completed | GlaxoSmithKline | 310 | 2022-05-07 | 2024-06-10 |
| N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Ciprodex, Ciprodex and 2% NAC - Otitis Media, Otorrhea | Phase 4 | Withdrawn | St. Paul's Hospital, Canada | 2019-11-29 | 2019-12-03 | |
| Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present Ofloxacin otic solution - Otitis Media | Phase 4 | Terminated | Boston Children's Hospital | 9 | 2019-05-16 | 2026-09-14 |
| Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion Mometasone 50 Mcg/Inh Nasal Spray, Antibiotics + Antihistamine (levocetirizine) + Nasal decongestants (Oxymetazoline 0.025%), Steroid Drug (prednisolone) - Otitis Media With Effusion | Phase 4 | Completed | Lumbini Medical College | 160 | 2018-09-05 | 2020-06-19 |
| Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Amoxicillin, Amoxicillin-Potassium Clavulanate, Macrolide - Acute Otitis Media | Phase 4 | Completed | University of Oulu | 73 | 2016-11-01 | 2022-08-11 |
| Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Ketorolac, Fentanyl - Pain, Postoperative, Otitis Media | Phase 4 | Unknown | Anica Crnkovic | 150 | 2015-05-01 | 2021-09-13 |
| Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Prevenar13, Synflorix - Otitis Media, Febrile Illness | Phase 4 | Completed | Menzies School of Health Research | 261 | 2013-03-12 | 2020-03-25 |
| Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Antibiotic prescription strategies - Rhinosinusitis, Acute Bronchitis | Phase 4 | Completed | Asociacion Colaboracion Cochrane Iberoamericana | 450 | 2012-06-01 | 2017-07-31 |
| Pneumococcal Vaccines Early and in Combination Synflorix, Prevenar13, COMBO - Otitis Media | Phase 4 | Completed | Menzies School of Health Research | 425 | 2011-08-01 | 2018-10-18 |
| Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Lansoprazole, Placebo - Otitis Media With Effusion | Phase 4 | Completed | Hamilton Health Sciences Corporation | 65 | 2010-03-01 | 2015-04-14 |
| Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal drops intilation (Taponoto ® ), drops intilation (Otocerum®), drops intilation (Placebo) - Ear Infection, Hearing Loss | Phase 4 | Completed | Hospital Clinic of Barcelona | 90 | 2008-09-01 | 2008-10-03 |
| Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Intranasal fentanyl, morphine IM, IV morphine - Otitis Media | Phase 4 | Completed | Baylor College of Medicine | 171 | 2008-05-01 | 2016-03-03 |
| Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age oseltamivir, placebo - Influenza | Phase 4 | Completed | Hospital District of Southwestern Finland | 409 | 2008-02-01 | 2009-06-19 |
| Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) dornase alfa (Pulmozyme®) - Otitis Media | Phase 4 | Completed | University of Colorado, Denver | 41 | 2007-01-01 | 2026-06-08 |
| Acute Otitis Media (AOM) Therapy Trial in Young Children amoxicillin-clavulanate, Placebo - Acute Otitis Media | Phase 4 | Completed | University of Pittsburgh | 291 | 2006-11-01 | 2016-12-05 |
Showing 20 of 27. Sign in to see all of them.
Otitis Media (21) · Otitis Media with Effusion (4) · Hearing Loss (2) · Hearing Loss, Conductive (2) · Respiratory Tract Infections (2) · Arthritis, Infectious (1) · Bronchitis (1) · Cough (1) · Influenza, Human (1) · Mastoiditis (1) · Orbital Cellulitis (1) · Osteomyelitis (1) · Pain, Postoperative (1) · Peritonsillar Abscess (1)
Ear Diseases (27) · Otorhinolaryngologic Diseases (27) · Infections (5) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Diseases (5) · Signs and Symptoms (5) · Neurologic Manifestations (4) · Otitis Media (4) · Hearing Disorders (3) · Nervous System Diseases (3) · Respiratory Tract Infections (3) · Sensation Disorders (3) · Abscess (1) · Arthritis (1)
Amoxicillin-Potassium Clavulanate Combination (7) · Amoxicillin (5) · 13-valent pneumococcal vaccine (2) · Cefdinir (2) · Fentanyl (2) · Mometasone Furoate (2) · PHiD-CV vaccine (2) · Acetylcysteine (1) · Adrenal Cortex Hormones (1) · Anti-Bacterial Agents (1) · Azithromycin (1) · Capsules (1) · Ciprofloxacin (1) · Dexmedetomidine (1) · Fatty Acids, Omega-3 (1)
Menzies School of Health Research (3) · Abbott (2) · Anica Crnkovic (1) · Asociacion Colaboracion Cochrane Iberoamericana (1) · Baylor College of Medicine (1) · Boston Children's Hospital (1) · Children's National Research Institute (1) · Deborah Gentile (1) · Eskisehir Osmangazi University (1) · GlaxoSmithKline (1) · Hamilton Health Sciences Corporation (1) · Hospital Clinic of Barcelona (1) · Hospital District of Southwestern Finland (1) · Indiana University (1) · Isola Tiberina - Gemelli Isola Hospital, Rome, Italy (1)
United States (11) · Finland (4) · Australia (3) · Canada (2) · Spain (2) · India (1) · Israel (1) · Italy (1) · Nepal (1) · Turkey (Türkiye) (1)
Amanda J Leach, PhD (2) · Aino Ruohola, MD, PhD (1) · Alejandro Hoberman, MD (1) · Anica Crnkovic, MD (1) · Brian D Westerberg, MD (1) · David Skoner, MD (1) · Dr. Diane Reid, MD FRCSC (1) · Dr. Gavin Rukholm, MD (1) · Helena Karlberg, MD (1) · James Wood, MD (1) · John D Mathews, PhD, DSc. (1) · Julia C Finkel, MD (1) · Kenneth R. Whittemore, MD, MS (1) · Kenny H Chan, MD (1)
PMID 35772449, PMID 38829821, PMID 42572144, PMID 12384383, PMID 20368317, PMID 20815736, PMID 21098526, PMID 21106443, PMID 21226576, PMID 21226577, PMID 22669347, PMID 25596202, PMID 26183005, PMID 26651157, PMID 28340091, PMID 30073253, PMID 30572868, PMID 32448790, PMID 33685411, PMID 37171965, PMID 37784098, PMID 37870130, PMID 38088821
2025 (1), U01AI066007 (1)