76 completed, 5 unknown, 4 terminated, 4 withdrawn. 25 Not applicable, 23 Phase 2, 16 Phase 3, 11 Phase 4, 9 Phase 1.
Follow Opiate Dependence: new trials by email Literature Review of Opiate Dependence trials Research Report on Opiate Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage Lidocaine, Lidocaine and Dexamethasone - Subarachnoid Hemorrhage, Aneurysmal, Headache | Phase 2 | Recruiting | The University of Texas Medical Branch, Galveston | 15 | 2026-01-02 | 2026-11-03 |
| Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder Accelerated intermittent theta-burst stimulation (aiTBS) - Opiate Dependence, Suicidal Ideation | Not applicable | Withdrawn | Stanford University | 2024-01-01 | 2024-07-16 | |
| Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain Real TBS to the mPFC, Sham TBS to the mPFC, Real TBS to the MC - Chronic Pain, Chronic Lower Back Pain | Not applicable | Completed | Wake Forest University Health Sciences | 38 | 2020-06-15 | 2023-05-12 |
| The Effect of Self-Forgiveness on Self-Stigma in Addiction. Six Step Model of Self-Forgiveness, Treatment as Usual (TAU) - Substance Use Disorders, Opiate Dependence | Not applicable | Completed | University of Pittsburgh | 130 | 2019-08-01 | 2021-09-05 |
| Impact of Lofexidine on Stress, Craving and Opioid Use Lofexidine, Placebo - Opioid-use Disorder, Opiate Dependence | Phase 2 | Completed | Medical University of South Carolina | 112 | 2019-06-26 | 2025-02-07 |
| Remote Observed Dosing of Suboxone to Improve Clinical Practice Suboxone Remote Observed Dosing, Suboxone Attention Control - Opioid-use Disorder, Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 16 | 2019-04-01 | 2023-07-27 |
| Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent iTBS to the left dlPFC, Sham iTBS to the left dlPFC, cTBS to the mPFC - Chronic Pain, Opiate Dependence | Early Phase 1 | Completed | Medical University of South Carolina | 24 | 2019-02-22 | 2023-02-10 |
| Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET 11UCB-J PET Scan - Opiate Dependence, Cocaine Dependence | Not applicable | Completed | Yale University | 41 | 2019-01-01 | 2024-07-16 |
| Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder Repetitive Transcranial Magnetic Stimulation, Sham rTMS - Opiate Dependence, Chronic Pain | Not applicable | Terminated | Medical University of South Carolina | 7 | 2018-09-28 | 2022-02-14 |
| Cognitive Function Before and After Opioid Reduction in Patients With Chronic Pain Chronic Nonmalignant Pain, Cognitive Impairment | Completed | Zealand University Hospital | 50 | 2018-01-01 | 2019-07-05 | |
| A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic sofosbuvir/velpatasvir - Hepatitis C, Chronic, Hepatitis C | Phase 4 | Completed | Community Research Initiative of New England | 11 | 2017-10-11 | 2021-05-13 |
| Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting Four-Session Mind Freedom Plan, Treatment as usual therapy - Cocaine Dependence, Cocaine Use Disorder | Not applicable | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 35 | 2017-06-05 | 2018-09-07 |
| Pilot Study of Contingency Management for Smoking Cessation Contingency Management - Smoking, Tobacco Smoking | Not applicable | Completed | King's College London | 40 | 2016-10-01 | 2017-11-29 |
| Medicinal Dependence and Chronic Pain: Addictive Evaluation in CETD Opiate Dependence, Chronic Pain | Completed | University Hospital, Brest | 128 | 2016-06-03 | 2018-08-17 | |
| Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction lofexidine administration in subjects seeking buprenorphine dose reduction - Substance Withdrawal Syndrome, Opiate Addiction | Phase 1 | Completed | USWM, LLC (dba US WorldMeds) | 10 | 2016-06-01 | 2017-10-26 |
| Outcomes of Opioid Addicted Prisoners With Extended-Release Injectable Naltrexone extended release naltrexone - Opiate Dependence | Phase 2 / Phase 3 | Completed | University of Pennsylvania | 146 | 2016-01-01 | 2021-01-28 |
| Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence Acceptance and Commitment Therapy, Information Motivation Behavioral Model - Opiate Dependence, Sexually Transmitted Diseases | Not applicable | Completed | Rhode Island Hospital | 14 | 2015-12-01 | 2018-08-29 |
| Study of Buprenorphine-Naloxone Sublingual Spray and Suboxone® Sublingual Film in Healthy Volunteers SL spray, SL film - Opiate Dependence | Phase 1 | Completed | INSYS Therapeutics Inc | 47 | 2015-06-01 | 2015-09-03 |
| Substance Dependence Satisfaction With Care and Quality Of Life Opiate Dependence, Alcoholism | Unknown | Central Hospital, Nancy, France | 600 | 2014-04-01 | 2016-09-09 | |
| Clinical Efficacy and Serum Proteomic Profiling of Suan-Zao-Ren Tang for Sleep Disturbance During Methadone Maintenance Suan-Zao-Ren Tang, Suan-Zao-Ren Tang placebo - Opiate Dependence | Phase 2 | Completed | China Medical University, Taiwan | 90 | 2013-07-01 | 2014-03-18 |
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Opioid-Related Disorders (90) · Substance-Related Disorders (16) · Cocaine-Related Disorders (11) · HIV Infections (7) · Chronic Pain (6) · Heroin Dependence (6) · Alcoholism (5) · Behavior, Addictive (4) · Hepatitis C (4) · Acquired Immunodeficiency Syndrome (3) · Substance Withdrawal Syndrome (3) · Depression (2) · Risk Reduction Behavior (2) · Smoking Cessation (2) · Back Pain (1)
Chemically-Induced Disorders (90) · Mental Disorders (90) · Narcotic-Related Disorders (90) · Substance-Related Disorders (74) · Communicable Diseases (13) · Infections (13) · Blood-Borne Infections (12) · RNA Virus Infections (12) · Virus Diseases (12) · Behavior (11) · Genital Diseases (10) · Urogenital Diseases (10) · Pathological Conditions, Signs and Symptoms (9) · Immune System Diseases (8) · Immunologic Deficiency Syndromes (8)
Buprenorphine (14) · Naltrexone (10) · Buprenorphine, Naloxone Drug Combination (9) · vivitrol (9) · Naloxone (6) · Therapeutics (4) · Methadone (3) · Atomoxetine Hydrochloride (2) · Modafinil (2) · Sugars (2) · Acceptance and Commitment Therapy (1) · Analgesics, Opioid (1) · Behavior Therapy (1) · Carvedilol (1) · Case Management (1)
Yale University (19) · Indivior Inc. (6) · Johns Hopkins University (5) · Alkermes, Inc. (4) · University of Pennsylvania (4) · Kuopio University Hospital (3) · Medical University of South Carolina (3) · Organization to Achieve Solutions in Substance Abuse (OASIS) (3) · The University of Texas Health Science Center, Houston (3) · Butler Hospital (2) · China Medical University, Taiwan (2) · Friends Research Institute, Inc. (2) · New York State Psychiatric Institute (2) · Sorlandet Hospital HF (2) · Albert Einstein College of Medicine (1)
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Kenneth Silverman, Ph.D. (3) · Bernard L. Silverman, MD (2) · David A. Fiellin, MD (2) · Diana L Sylvestre, MD (2) · George E Woody, MD (2) · Oistein Kristensen, MD (2) · Richard S Schottenfeld, MD (2) · Richard S. Schottenfeld, M.D. (2) · Robert P Schwartz, M.D. (2) · Ulrich Tacke, MD, PhD (2) · Alexander Okhapkin, Prof. (1) · Alexander Sofronov, Prof. (1) · Alexey Egorov, Prof. (1) · Amy E Colson, MD MPH (1)
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R01DA014718 (4), P50DA009262 (2), R01DA010746 (2), R01DA019497 (2), K23DA021512 (1), K23DA024050 (1), K23DA025049 (1), R01DA013108 (1), R01DA013441 (1), R01DA013636 (1), R01DA014537 (1), R01DA018696 (1), R01DA019436 (1), R01DA019511 (1), R01DA019934 (1)