14 completed, 3 active not recruiting, 2 not yet recruiting, 2 recruiting. 14 Not applicable, 2 Phase 1, 1 Early Phase 1, 1 Phase 2, 1 Phase 4.
Follow Nicotine: new trials by email Literature Review of Nicotine trials Research Report on Nicotine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues Vaping of synthetic S-nicotine, Vaping of racemic nicotine (S-/R-nicotine), Vaping of 6-methylnicotine - Nicotine, Vaping | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 24 | 2026-08-05 | 2026-09-30 |
| CHECK-NIRS2D-Study NIRS, Tissue Oxygenation | Recruiting | Heinrich-Heine University, Duesseldorf | 20 | 2026-07-28 | 2026-10-02 | |
| Support Your Heart, Phase 1 Support Your Heart - Cardio Vascular Disease, Obesity & Overweight | Not applicable | Active not recruiting | George Washington University | 20 | 2026-06-01 | 2026-07-14 |
| Smoking Harm Reduction Using E-cigarettes and Cytisine E-cigarette e-liquid, Cytisine - Tobacco Smoking, Harm Reduction | Not applicable | Not yet recruiting | Centre for Addiction and Mental Health | 6000 | 2026-05-01 | 2026-03-19 |
| Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking Daridorexant 50 mg, Placebo - Smoking, Nicotine | Phase 4 | Not yet recruiting | Legacy Health System | 44 | 2026-02-10 | 2026-01-09 |
| Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes THS with LEVIA (ad libitum), THS with TEREA (ad libitum), THS with LEVIA - Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 24 | 2026-02-01 | 2026-05-05 |
| Understanding Vape Marketing Study Working group, Focus group - E-cigarette, Vaping | Enrolling by invitation | Boston Children's Hospital | 46 | 2025-08-04 | 2025-08-19 | |
| Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Current Smokers VM16, VM32, Cigarette (CC) - Nicotine | Not applicable | Active not recruiting | Philip Morris Products S.A. | 16 | 2025-07-17 | 2025-08-22 |
| Nicotine and Cannabis Vape Labeling Experiment - Spring 2025 Vaping Device Labeling - Vaping, Adolescent | Not applicable | Completed | University of Southern California | 3048 | 2025-03-03 | 2026-05-22 |
| Substance Consumption, Personality, and Cognitive Functioning of Chess Players Addiction, Alcohol | Completed | Central Institute of Mental Health, Mannheim | 756 | 2024-01-31 | 2025-05-01 | |
| Developing E-liquid Product Standards (Sweet Spot Study) Vaping study EC A, Vaping study EC B, Vaping study EC C - Nicotine, Nicotine Vaping | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 150 | 2023-05-30 | 2025-04-10 |
| Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL - Nicotine, E-liquid Flavors | Phase 2 | Completed | Yale University | 54 | 2022-10-27 | 2024-08-05 |
| Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence P4M3 CA35, P4M3 CM35, CIG - Nicotine, Vaping | Not applicable | Completed | Philip Morris Products S.A. | 74 | 2022-07-15 | 2024-03-13 |
| Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes CA35, CM35, Cig - Nicotine Vaping, Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 36 | 2022-04-28 | 2024-04-26 |
| Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Cool Mint Mini Dry in Healthy Smokers NP-1, NP-2, NP-3 - Smoking, Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 31 | 2022-03-15 | 2024-09-27 |
| Behavioral Pharmacology of Cannabis and Nicotine Cannabis, Nicotine - Cannabis, Nicotine | Phase 1 | Completed | Johns Hopkins University | 26 | 2020-09-15 | 2024-04-17 |
| Inner Engineering Yoga Program on Short and Long Term Health Effects (ISHA-Impact): A Longitudinal Study Inner Engineering Intervention - Mediation, Mood | Not applicable | Completed | Beth Israel Deaconess Medical Center | 618 | 2019-03-12 | 2025-01-27 |
| QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt Real cTBS, Sham cTBS, Real iTBS - Smoking, Cigarette, Craving | Not applicable | Terminated | Medical University of South Carolina | 25 | 2018-09-04 | 2021-03-24 |
| The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study Prazosin - Cigarette Smoking Toxicity, Nicotine | Phase 1 | Withdrawn | University of Louisville | 2018-03-13 | 2018-07-26 | |
| Switching to Low Oxidant Content Cigarettes in Adult Smokers Reduced ROS/RNS content products, Typical to high (ROS/NOS) products - Nicotine, Oxidative Stress | Not applicable | Completed | Milton S. Hershey Medical Center | 30 | 2017-07-11 | 2019-03-04 |
Showing 20 of 24. Sign in to see all of them.
Vaping (9) · Smoking (5) · Behavior, Addictive (4) · Depression (3) · Anxiety Disorders (2) · Marijuana Abuse (2) · Adolescent Behavior (1) · Alcohol Drinking (1) · Atherosclerosis (1) · Cigarette Smoking (1) · Habits (1) · Harm Reduction (1) · Motor Activity (1) · Negotiating (1) · Obesity (1)
Behavior (17) · Smoking (8) · Mental Disorders (5) · Compulsive Behavior (4) · Impulsive Behavior (4) · Behavioral Symptoms (3) · Chemically-Induced Disorders (3) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Substance-Related Disorders (2) · Tobacco Use (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Body Weight (1) · Cardiovascular Diseases (1)
Nicotine (5) · Tobacco Products (3) · Fibronectins (1) · Focus Groups (1) · Fruit (1) · Mecamylamine (1) · Menthol (1) · Prazosin (1) · cytisine (1) · daridorexant (1) · nabiximols (1)
Philip Morris Products S.A. (5) · Yale University (2) · Beth Israel Deaconess Medical Center (1) · Boston Children's Hospital (1) · Central Institute of Mental Health, Mannheim (1) · Centre for Addiction and Mental Health (1) · George Washington University (1) · Heinrich-Heine University, Duesseldorf (1) · Insel Gruppe AG, University Hospital Bern (1) · Johns Hopkins University (1) · Karolinska Institutet (1) · Legacy Health System (1) · Medical University of South Carolina (1) · Milton S. Hershey Medical Center (1) · Ohio State University Comprehensive Cancer Center (1)
United States (15) · United Kingdom (3) · Germany (2) · Poland (1) · Sweden (1) · Switzerland (1)
Britta Hahn, Ph.D. (1) · Christelle Haziza, PhD (1) · Colleen A Hanlon, PhD (1) · Cynthia N Epperson, M.D. (1) · Elise DeVito, PhD (1) · John Richie, Ph.D (1) · Kevin Jensen, Ph.D. (1) · Magnus Lundback, Prof. (1) · Malte Kelm, MD (1) · Mehmet Sofuoglu, M.D.,Ph.D. (1) · Melanie Fein, MD (1) · Melissa Napolitano, PhD (1) · Patrick Winiger, MD (1) · Rajkumar Chetty, MD (1) · Ryan Vandrey (1)
PMID 35572309, PMID 37699050, PMID 39968198
2025 (1), K24DA048160 (1), P50DA036107 (1), R00CA267477 (1), R01CA229617 (1), R01DA046360 (1), R21DA027894 (1), R21DA044377 (1), R34HL175017 (1), U54CA180905 (1)