44 completed, 13 unknown, 4 active not recruiting, 3 recruiting. 40 Phase 2, 23 Phase 3, 5 Not applicable, 5 Phase 1, 1 Early Phase 1.
Follow Procarbazine: new trials by email Literature Review of Procarbazine trials Research Report on Procarbazine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma Rituximab, Methotrexate, Procarbazine - Lymphoma | Phase 2 | Recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 65 | 2025-11-06 | 2026-09-30 |
| Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL ONO-4059, Rituximab, Methotrexate - Primary Central Nervous System Lymphoma | Phase 1 | Active not recruiting | Ono Pharmaceutical Co., Ltd. | 20 | 2024-05-17 | 2026-10-06 |
| A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab Biospecimen Collection, Bleomycin Sulfate, Brentuximab Vedotin - Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 1875 | 2023-05-11 | 2026-10-22 |
| Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11) Pembrolizumab, Doxorubicin, Vinblastine - Classical Hodgkin Lymphoma | Phase 2 | Completed | Merck Sharp & Dohme LLC | 146 | 2021-10-07 | 2025-06-06 |
| RL-MPV Followed by BBC HCT Using Autologous Stem Cells and Maintenance Therapy With Nivolumab for Newly Diagnosed PCNSL Rituximab, Methotrexate, Vincristine, Procarbazine, Lenalidomide - Primary CNS Lymphoma | Phase 2 | Unknown | National Research Center for Hematology, Russia | 30 | 2021-05-17 | 2022-06-21 |
| A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas). CETEG, PCV, RT - Oligodendroglioma | Phase 3 | Recruiting | University Hospital Heidelberg | 406 | 2021-04-07 | 2026-02-03 |
| Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System Rituximab, Methotrexate, Procarbazine - Primary Central Nervous System Lymphoma | Phase 2 | Completed | International Extranodal Lymphoma Study Group (IELSG) | 72 | 2019-06-15 | 2025-01-30 |
| BrEPEM-LH-22017 for Older Patients With Untreated Hodgkin Lymphoma (HL) BrentuximabVedotin (BV) - Hodgkin Lymphoma | Phase 1 / Phase 2 | Unknown | Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea | 41 | 2018-08-08 | 2024-02-26 |
| Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate - AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma | Phase 2 | Completed | AIDS Malignancy Consortium | 7 | 2016-09-15 | 2022-10-10 |
| HD21 for Advanced Stages Bleomycin, Etoposide, Doxorubicin - Classical Hodgkin Lymphoma | Phase 3 | Unknown | University of Cologne | 1500 | 2016-07-01 | 2024-05-13 |
| Procarbazine Hydrochloride Capsule (Natulan®) Clinical Trial Protocol Natulan, ABVD - Advanced Hodgkin's Lymphoma | Not applicable | Unknown | Lee's Pharmaceutical Limited | 92 | 2016-06-01 | 2018-09-04 |
| Brentuximab Vedotin as Consolidation Treatment in Patients With Stage I/II HL and PET Positivity After 2 Cycles of ABVD brentuximab vedotin, Cyclophosphamide, Adriamycin - Hodgkin Lymphoma | Phase 2 | Completed | The Lymphoma Academic Research Organisation | 40 | 2015-04-01 | 2021-07-26 |
| Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Patients With Newly Diagnosed or Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL) Ibrutinib, HD- Methotrexate (MTX), Rituximab + HD- Methotrexate (MTX) - Adult Patients With Newly Diagnosed or Relapsed or Refractory Primary Central Nervous System Lymphoma (PCNSL), Or Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL) | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 93 | 2014-12-08 | 2026-02-02 |
| Chemotherapy Based on PET Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma Doxorubicin, Bleomycin, Vinblastine - Lymphoma | Phase 2 | Terminated | ECOG-ACRIN Cancer Research Group | 6 | 2013-05-24 | 2023-06-29 |
| Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Classical Hodgkin Lymphoma Etoposide, Cyclophosphamide, Doxorubicin - Hodgkin Lymphoma | Phase 2 | Completed | University of Cologne | 100 | 2012-10-01 | 2018-10-29 |
| Procarbazine and Lomustine in Recurrent Glioblastoma lomustine and procarbazine - Recurrent Glioblastoma Multiforme | Phase 2 | Unknown | Incheon St.Mary's Hospital | 52 | 2012-10-01 | 2012-12-03 |
| HD17 for Intermediate Stage Hodgkin Lymphoma BEACOPPescalated (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone), ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine), 30Gy IF-RT (Involved-Field Radiotherapy) - Hodgkin Lymphoma | Phase 3 | Completed | University of Cologne | 1100 | 2012-01-13 | 2020-04-06 |
| Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma Rituximab, Cytarabine, Methotrexate - Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects | Phase 2 | Completed | Radiation Therapy Oncology Group | 91 | 2011-09-01 | 2023-07-20 |
| Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma Bleomycin Sulfate, Doxorubicin Hydrochloride, Procarbazine Hydrochloride - Lymphoma | Phase 2 | Completed | Alliance for Clinical Trials in Oncology | 164 | 2010-05-01 | 2021-06-14 |
| Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene Cilengitide - Newly Diagnosed Non Methylated Glioblastoma Multiforme Grade 4 | Phase 2 | Unknown | Northern Sydney and Central Coast Area Health Service | 48 | 2009-11-01 | 2011-07-26 |
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Lymphoma (29) · Hodgkin Disease (20) · Central Nervous System Neoplasms (16) · Astrocytoma (11) · Oligodendroglioma (10) · Brain Neoplasms (9) · Glioblastoma (9) · Gliosarcoma (7) · Glioma (6) · Recurrence (6) · Lymphoma, Non-Hodgkin (4) · Lymphoma, Follicular (3) · Neurotoxicity Syndromes (3) · Lymphoma, AIDS-Related (2) · Lymphoma, Mantle-Cell (2)
Memorial Sloan Kettering Cancer Center (6) · University of Cologne (5) · Case Comprehensive Cancer Center (4) · European Organisation for Research and Treatment of Cancer - EORTC (4) · Alliance for Clinical Trials in Oncology (3) · Children's Cancer and Leukaemia Group (3) · M.D. Anderson Cancer Center (3) · Radiation Therapy Oncology Group (3) · Children's Oncology Group (2) · Christine Mauz-Körholz (2) · University College, London (2) · AIDS Malignancy Consortium (1) · Colorado Health Foundation (1) · ECOG-ACRIN Cancer Research Group (1) · Eastern Cooperative Oncology Group (1)
United States (34) · Germany (11) · Canada (9) · United Kingdom (9) · France (7) · Italy (6) · Australia (5) · Netherlands (5) · Belgium (4) · Israel (3) · Poland (3) · Spain (3) · Switzerland (3) · Austria (2) · Finland (2)
Scot C. Remick, MD (4) · Antonio Omuro, MD (2) · Christian Grommes, MD (2) · Dieter Koerholz, MD (2) · Edward G. Shaw, MD (2) · Jan C. Buckner, MD (2) · Joann Ater, MD (2) · John Martin, MD (2) · Peter Borchmann, Prof. (2) · Tanya Trippett, MD (2) · Volker Diehl, Prof. (2) · A. Barratt, MD (1) · Alessandro M Gianni, MD (1) · Alison L. Hannah, MBBS (1)
PMID 40135712, PMID 35731991, PMID 37505794, PMID 11586105, PMID 12525516, PMID 14670747, PMID 15936157, PMID 16314615, PMID 16782910, PMID 16782911, PMID 17097834, PMID 17549014, PMID 17989384, PMID 18089866, PMID 18089867, PMID 18371182, PMID 18976072, PMID 19224764, PMID 19783377, PMID 19828373, PMID 19901104, PMID 20160062, PMID 20235190, PMID 20713848, PMID 20820870, PMID 20855843, PMID 21079154, PMID 21246521, PMID 21774708, PMID 21914791, PMID 21990399, PMID 22665535, PMID 22851558, PMID 23071237, PMID 23071247, PMID 23269986, PMID 23509310, PMID 24101038, PMID 24121121, PMID 24419119, PMID 25568347, PMID 27050206, PMID 27114593, PMID 27332902, PMID 27843136, PMID 29360414, PMID 29393183, PMID 29416652, PMID 30010775, PMID 30049811
P30CA043703 (4), P30CA016672 (2), 2004 (1), 2014 (1), 2018 (1), 2025 (1), U01CA079778 (1), U01CA080098 (1), U01CA121947 (1), U10CA032102 (1), U10CA180821 (1), U10CA180886 (1)