11 completed, 3 terminated, 2 unknown. 16 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 11, Terminated 3, Unknown 2 |
| Phase 1 | 1 | Completed 1 |
Follow Neurotoxicity: new trials by email Literature Review of Neurotoxicity trials Research Report on Neurotoxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity Anakinra, Axicabtagene Ciloleucel - Non Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma | Phase 2 | Completed | Marcela V. Maus, M.D.,Ph.D. | 15 | 2020-10-01 | 2025-11-25 |
| o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate Cancer Tadalafil 5 mg - Prostate Cancer Metastatic Disease, Chemotherapy Induced Peripheral Neuropathy (CIPN) | Phase 2 | Completed | Tri-Service General Hospital (TSGH) | 90 | 2020-01-05 | 2026-01-12 |
| Monosialoganglioside Preventing Neurotoxicity Induced by Albumin-bound Paclitaxel Chemotherapy in Lung Cancer Patients monosialoganglioside - Neurotoxicity | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 106 | 2015-07-01 | 2015-07-17 |
| Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D Pathway Vitamin D3 - Neurotoxicity | Phase 2 | Terminated | Gerald Higa, PharmD. | 9 | 2012-01-01 | 2021-11-10 |
| Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma Rituximab, Cytarabine, Methotrexate - Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects | Phase 2 | Completed | Radiation Therapy Oncology Group | 91 | 2011-09-01 | 2023-07-20 |
| Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor modafinil, placebo - Brain and Central Nervous System Tumors, Cognitive/Functional Effects | Phase 2 | Completed | University of South Florida | 112 | 2011-08-01 | 2021-08-13 |
| Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy questionnaire administration, Sensory Neuropathy Scale instrument, Quality of Life instrument - Chemotherapeutic Agent Toxicity, Neurotoxicity | Phase 2 | Completed | Virginia Commonwealth University | 18 | 2009-06-12 | 2017-03-29 |
| Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma glucarpidase, leucovorin calcium, methotrexate - Chemotherapeutic Agent Toxicity, Lymphoma | Phase 1 / Phase 2 | Completed | University College, London | 4 | 2008-07-01 | 2014-01-27 |
| Bortezomib, Thalidomide, and Dexamethasone After Melphalan and Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma bortezomib, dexamethasone, melphalan - Multiple Myeloma and Plasma Cell Neoplasm, Neurotoxicity | Phase 2 | Completed | City of Hope Medical Center | 45 | 2008-03-08 | 2026-11-02 |
| Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma cyclophosphamide, doxorubicin hydrochloride, etoposide - Lymphoma, Neurotoxicity | Phase 2 | Completed | University College, London | 47 | 2008-03-01 | 2014-12-04 |
| Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin FOLFOX regimen, fluorouracil, leucovorin calcium - Chemotherapeutic Agent Toxicity, Colorectal Cancer | Phase 2 | Unknown | Institut Cancerologie de l'Ouest | 206 | 2007-09-01 | 2009-07-08 |
| Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors Glutamine, Placebo - Kidney Cancer, Leukemia | Phase 2 | Completed | Columbia University | 56 | 2004-10-01 | 2016-09-09 |
| Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors Amifostine - Breast Cancer, Lung Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 24 | 2004-05-01 | 2012-10-17 |
| Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression Adderall-XR®, Concerta® - Depression, Neurotoxicity | Phase 2 | Terminated | University of South Florida | 12 | 2003-08-01 | 2014-02-03 |
| Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer amifostine trihydrate, cisplatin, paclitaxel - Cervical Cancer, Endometrial Cancer | Phase 2 | Terminated | Gynecologic Oncology Group | 1998-12-01 | 2013-04-11 | |
| Combination Chemotherapy in Treating Patients With Metastatic Ovarian Cancer or Non-small Cell Lung Cancer amifostine trihydrate, carboplatin, paclitaxel - Lung Cancer, Neurotoxicity | Phase 2 | Completed | University of California, San Francisco | 80 | 1997-05-01 | 2012-09-21 |
Neurotoxicity Syndromes (16) · Lymphoma (4) · Peripheral Nervous System Diseases (4) · Carcinoma, Ovarian Epithelial (3) · Ovarian Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Lung Neoplasms (2) · Lymphoma, Large B-Cell, Diffuse (2) · Sarcoma (2) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Central Nervous System Neoplasms (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Cytokine Release Syndrome (1)
Chemically-Induced Disorders (16) · Nervous System Diseases (16) · Poisoning (16) · Neoplasms (11) · Neoplasms by Histologic Type (9) · Hemic and Lymphatic Diseases (6) · Immune System Diseases (6) · Immunoproliferative Disorders (6) · Lymphoproliferative Disorders (6) · Neoplasms by Site (6) · Lymphatic Diseases (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Neoplasms, Glandular and Epithelial (4) · Neuromuscular Diseases (4)
Amifostine (3) · Leucovorin (2) · Methotrexate (2) · Paclitaxel (2) · Procarbazine (2) · Radiotherapy (2) · Vincristine (2) · Bortezomib (1) · Carboplatin (1) · Cholecalciferol (1) · Cisplatin (1) · Cyclophosphamide (1) · Cytarabine (1) · Cytogenetic Analysis (1) · Dexamethasone (1)
University College, London (2) · University of South Florida (2) · City of Hope Medical Center (1) · Columbia University (1) · Gerald Higa, PharmD. (1) · Gynecologic Oncology Group (1) · Institut Cancerologie de l'Ouest (1) · M.D. Anderson Cancer Center (1) · Marcela V. Maus, M.D.,Ph.D. (1) · Peking University Cancer Hospital & Institute (1) · Radiation Therapy Oncology Group (1) · Tri-Service General Hospital (TSGH) (1) · University of California, San Francisco (1) · Virginia Commonwealth University (1)
United States (10) · United Kingdom (2) · China (1) · France (1) · Israel (1) · Taiwan (1)
Antonio Omuro, MD (1) · Arthur Forman, MD (1) · David H. Moore, MD (1) · Erick Gamelin, MD (1) · Firoozeh Sahebi, MD (1) · Gerald Higa, PharmD (1) · Jeffrey P. Krischer, MD, PhD (1) · Jian Fang (1) · Julia L. Glade-Bender, MD (1) · Kirit Ardeshna (1) · Margaret Booth-Jones, PhD (1) · Matt J Frigault, MD (1) · Nicole J. Ullrich, MD, PhD (1) · Robert J. Ignoffo, PharmD (1) · Roderick Johnson, MD (1)
U10CA081920 (2), P30CA033572 (1)