146 completed, 46 recruiting, 44 unknown, 32 active not recruiting. 315 Phase 3, 38 Phase 2.
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Intraoperative Ultrasound for Brain Tumor Surgery Enhanced by AI BrainUS-AI real-time intraoperative ultrasound segmentation system - Brain Tumor Adult | Phase 3 | Not yet recruiting | Hospital del Rio Hortega | 100 | 2026-12-01 | 2026-09-17 |
| A Study to Evaluate The Long-Term Safety And Efficacy of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis Rozanolixizumab - Ocular Myasthenia Gravis | Phase 3 | Recruiting | UCB Biopharma SRL | 100 | 2026-09-16 | 2026-10-27 |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Efficacy and Safety of Ravulizumab in Chinese Adults Participants With Generalized Myasthenia Gravis (gMG) Ravulizumab - Generalized Myasthenia Gravis, gMG | Phase 3 | Recruiting | Alexion Pharmaceuticals, Inc. | 20 | 2026-07-27 | 2026-10-21 |
| A Phase 3 Study to Evaluate Claseprubart in Adults With Generalized Myasthenia Gravis (EMERGE) Claseprubart, Placebo - Myasthenia Gravis, Generalized | Phase 3 | Recruiting | Dianthus Therapeutics | 195 | 2026-06-29 | 2026-10-30 |
| A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis Rozanolixizumab, Placebo - Ocular Myasthenia Gravis | Phase 3 | Recruiting | UCB Biopharma SRL | 120 | 2026-05-27 | 2026-10-27 |
| Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases: Methylprednisolone (Corticosteroid), Dexamethasone - Brain Metastases From Solid Tumors | Phase 2 / Phase 3 | Not yet recruiting | The Second Affiliated Hospital of Hainan Medical University | 400 | 2026-04-15 | 2026-04-21 |
| Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas TQ-B3234 capsules, TQ-B3234 placebo - Plexiform Neurofibroma | Phase 3 | Recruiting | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 177 | 2026-03-31 | 2026-05-27 |
| Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases FSRT, HA-WBRT-SIB, Bevacizumab - Lung Adenocarcinoma, Brain Metastases | Phase 3 | Recruiting | Sun Yat-sen University | 220 | 2026-03-20 | 2026-04-06 |
| Zilucoplan for Severe gMG Exacerbations Zilucoplan® - Generalized Myasthenia Gravis (gMG) | Phase 3 | Recruiting | Miriam Freimer | 15 | 2026-01-20 | 2026-08-28 |
| A Study of Telitacicept in Patients With Ocular Myasthenia Gravis (OMG) Telitacicept, Placebo - Myasthenia Gravis, Ocular | Phase 3 | Recruiting | RemeGen Co., Ltd. | 120 | 2026-01-13 | 2026-04-09 |
| Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis Nipocalimab, Efgartigimod - Myasthenia Gravis | Phase 3 | Recruiting | Janssen Research & Development, LLC | 115 | 2026-01-05 | 2026-11-03 |
| Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of Large Brain Metastases Neoadjuvant Stereotactic Body Radiation Therapy (SBRT), Multi-fraction Stereotactic Body Radiation Therapy (SBRT) - Brain Metastasis | Phase 3 | Not yet recruiting | Maciej Harat | 98 | 2026-01-01 | 2026-01-09 |
| Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery. Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block - Posterior Fossa Tumor | Phase 3 | Recruiting | Children's Cancer Hospital Egypt 57357 | 260 | 2025-12-17 | 2026-10-16 |
| DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. Entrectinib - Haematological Malignancy, Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2025-11-30 | 2025-11-24 |
| Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma TLX-101-Tx + Lomustine, TLX101-Tx - Neoplastic Disease, Glioblastoma | Phase 3 | Recruiting | Telix Pharmaceuticals (Innovations) Pty Limited | 50 | 2025-11-02 | 2026-08-11 |
| Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients Steroids therapy, Placebo - Vestibular Schwannoma, Facial Nerve Paralysis | Phase 3 | Recruiting | Beijing Tiantan Hospital | 364 | 2025-10-09 | 2026-10-26 |
| Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3 D1-3-5 radiotherapy, D1-2-3 radiotherapy - Brain Metastases | Phase 3 | Not yet recruiting | Centre Paul Strauss | 264 | 2025-10-01 | 2025-09-11 |
| Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue Methylphenidate (MPH), Placebo - Brain Tumor, Pediatric, Cancer-related Fatigue | Phase 3 | Recruiting | Odense University Hospital | 50 | 2025-09-02 | 2026-11-03 |
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Brain Neoplasms (148) · Myasthenia Gravis (79) · Central Nervous System Neoplasms (40) · Glioblastoma (39) · Astrocytoma (32) · Glioma (28) · Neoplasm Metastasis (27) · Carcinoma, Non-Small-Cell Lung (21) · Breast Neoplasms (18) · Neoplasms (18) · Gliosarcoma (16) · Oligodendroglioma (14) · Sarcoma (13) · Fibrosarcoma (11) · Lung Neoplasms (11)
Nervous System Diseases (315) · Neoplasms by Site (301) · Neoplasms (297) · Central Nervous System Diseases (182) · Brain Diseases (169) · Central Nervous System Neoplasms (165) · Neoplasms by Histologic Type (114) · Neoplasms, Nerve Tissue (102) · Immune System Diseases (98) · Neurodegenerative Diseases (96) · Neuromuscular Diseases (96) · Paraneoplastic Syndromes (91) · Paraneoplastic Syndromes, Nervous System (91) · Autoimmune Diseases of the Nervous System (89)
Radiotherapy (45) · Temozolomide (29) · Radiosurgery (27) · Lomustine (17) · Vincristine (16) · Carboplatin (11) · Bevacizumab (10) · Cisplatin (10) · Cyclophosphamide (10) · Etoposide (10) · Ifosfamide (10) · Doxorubicin (9) · Procarbazine (9) · Filgrastim (8) · Surgical Procedures, Operative (8)
European Organisation for Research and Treatment of Cancer - EORTC (17) · Alexion Pharmaceuticals, Inc. (13) · UCB Biopharma SRL (13) · argenx (10) · M.D. Anderson Cancer Center (8) · Novartis Pharmaceuticals (8) · NRG Oncology (7) · Radiation Therapy Oncology Group (7) · Sun Yat-sen University (7) · Alliance for Clinical Trials in Oncology (6) · Children's Oncology Group (6) · National Cancer Institute (NCI) (5) · Assistance Publique - Hôpitaux de Paris (4) · Catalyst Pharmaceuticals, Inc. (4) · Astellas Pharma Inc (3)
United States (157) · Canada (104) · Germany (83) · Italy (75) · United Kingdom (73) · France (72) · Spain (70) · Poland (55) · Japan (54) · China (53) · Netherlands (52) · Belgium (47) · Australia (40) · Denmark (35) · Switzerland (33)
Roger Stupp, MD (5) · Paul D. Brown, MD (4) · Edward G. Shaw, MD (3) · William Shapiro, MD (3) · Amar Gajjar, MD (2) · Andrey S. Bryukhovetskiy, MD (2) · Brigitta Baumert, MD, PhD (2) · Gil Wolfe, MD (2)
PMID 37059507, PMID 42388397, PMID 19801201, PMID 25303679, PMID 25789053, PMID 27458945, PMID 30905021, PMID 32058845, PMID 32189108, PMID 32426038, PMID 32691060, PMID 32700461, PMID 33229455, PMID 33329303, PMID 33676197, PMID 34146511, PMID 34498507, PMID 34590717, PMID 35731991, PMID 37059508, PMID 38400914, PMID 39314260, PMID 40105996, PMID 40504283, PMID 42855714, PMID 10549493, PMID 11586105, PMID 12651674, PMID 12697884, PMID 12925241, PMID 15001263, PMID 15158627, PMID 15234047, PMID 15251162, PMID 15254054, PMID 15328187, PMID 15465203, PMID 15758009, PMID 15758010, PMID 15890570, PMID 16062084, PMID 16148284, PMID 16203762, PMID 16258095, PMID 16314619, PMID 16321761, PMID 16648043, PMID 16735709, PMID 16757720, PMID 16782910
2023 (10), U10CA180868 (5), 2019 (4), 2025 (4), U10CA098543 (4), 2014 (3), 2015 (3), 2018 (3), 2009 (2), P30CA016672 (2), U10CA021661 (2), U10CA180886 (2), UG1CA189867 (2), 2004 (1), 2016 (1)