137 completed, 58 active not recruiting, 32 recruiting, 14 terminated. 121 Phase 2, 114 Phase 3, 29 Phase 1, 11 Not applicable, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT) Radiation Therapy, Standard of Care Radiation Therapy, No Intervention - Breast Cancer | Phase 3 | Not yet recruiting | NRG Oncology | 5270 | 2027-01-30 | 2026-09-30 |
| Comparing Radiation After Surgery to Observation After Surgery in Patients With Clinical Low-Risk, Molecular High-Risk Meningioma, and Evaluating Observation After Surgery in Patients With Clinical and Molecular Low-Risk Meningioma Patient Observation, Magnetic Resonance Imaging, Biospecimen Collection - Grade 1 Meningioma, Grade 2 Meningioma | Phase 3 | Not yet recruiting | NRG Oncology | 464 | 2027-01-28 | 2026-08-25 |
| Testing Repeat Radiation Therapy for Recurrent Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Immunotherapy - Locally Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | NRG Oncology | 138 | 2026-12-18 | 2026-09-23 |
| Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin Biospecimen Collection, Carboplatin, Cetuximab - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 454 | 2026-07-31 | 2026-08-17 |
| Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma | Phase 3 | Recruiting | NRG Oncology | 398 | 2026-07-16 | 2026-09-10 |
| Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial Atezolizumab, Bevacizumab, Biospecimen Collection - Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 226 | 2026-02-26 | 2026-08-17 |
| Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer SBRT, First or second-line standard of care therapy - Non-small Cell Lung Cancer | Phase 3 | Recruiting | Canadian Cancer Trials Group | 320 | 2025-12-16 | 2026-07-14 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-08-18 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| E-Mindfulness Approaches for Living After Breast Cancer Mindfulness (MAPs) Live Online, Mindfulness (MAPs) Digital App, Meditation Only Control Group - Breast Cancer, Depression | Phase 3 | Recruiting | NRG Oncology | 402 | 2025-06-27 | 2026-08-04 |
| Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer Best Practice, Biospecimen Collection, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | NRG Oncology | 98 | 2025-06-23 | 2026-08-17 |
| Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response Abiraterone, Enzalutamide, Apalutamide - Prostate Cancer (Adenocarcinoma) | Phase 3 | Recruiting | Canadian Cancer Trials Group | 830 | 2025-05-28 | 2026-07-14 |
| Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial Best Practice, Biospecimen Collection, Bone Metastases Treatment - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 3 | Active not recruiting | NRG Oncology | 280 | 2025-05-07 | 2026-08-17 |
| Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer Bevacizumab, Biospecimen Collection, Computed Tomography - Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma | Phase 3 | Recruiting | NRG Oncology | 880 | 2025-03-12 | 2026-08-07 |
| Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Recruiting | NRG Oncology | 115 | 2025-03-04 | 2026-08-17 |
| Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors Aerobic Exercise, Behavioral Intervention, Follow-Up - Cancer-related Cognitive Dysfunction, Primary Brain Neoplasm | Not applicable | Recruiting | Emory University | 60 | 2025-02-13 | 2026-01-09 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community-AIM 2 PYTEST® 14C-Urea Capsule Breath Test (at Home), PYTEST® 14C-Urea Capsule Breath Test (Standard Retesting In-Person) - H. Pylori Infection, Gastric Cancer | Phase 4 | Completed | University of Miami | 50 | 2024-11-06 | 2026-10-16 |
| Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment Counseling, Health Education, Interview - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Not applicable | Recruiting | NRG Oncology | 600 | 2024-10-14 | 2026-09-10 |
| Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial) Binimetinib, Biopsy Procedure, Biospecimen Collection - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 1 | 2024-09-13 | 2026-03-03 |
Showing 20 of 251. Sign in to see all of them.
Prostatic Neoplasms (28) · Ovarian Neoplasms (27) · Breast Neoplasms (26) · Fallopian Tube Neoplasms (23) · Carcinoma, Non-Small-Cell Lung (19) · Lung Neoplasms (19) · Brain Neoplasms (15) · Squamous Cell Carcinoma of Head and Neck (15) · Glioblastoma (13) · Uterine Cervical Neoplasms (12) · Endometrial Neoplasms (11) · Gliosarcoma (11) · Central Nervous System Neoplasms (9) · Oropharyngeal Neoplasms (9) · Astrocytoma (8)
Magnetic Resonance Spectroscopy (53) · Radiotherapy (51) · Radiotherapy, Intensity-Modulated (47) · Specimen Handling (46) · Paclitaxel (44) · Cisplatin (38) · Taxes (38) · Radiation (37) · Carboplatin (35) · Disulfides (25) · Immunoglobulin G (25) · 1,2-diaminocyclohexaneplatinum II citrate (21) · Radiotherapy, Conformal (21) · Bevacizumab (20) · Platinum (20)
United States (245) · Canada (116) · Puerto Rico (29) · South Korea (20) · Japan (15) · Hong Kong (13) · Israel (13) · Switzerland (8) · Ireland (7) · Saudi Arabia (7) · Australia (6) · China (5) · Singapore (5) · Netherlands (3) · Peru (3)
Minesh P. Mehta, MD (3) · Oliver Sartor, MD (3) · Vinai Gondi (3) · Alessandro D Santin (2) · Anuja Jhingran, MD (2) · Benjamin Movsas, MD (2) · David M Gershenson (2) · Douglas W. Arthur, MD (2) · Elizabeth M. Gore, MD (2) · Jeffrey Bradley, MD (2) · John H Farley (2) · John K Chan (2) · Jung-min Lee (2) · Jyoti S Mayadev (2) · Loren K Mell (2)
PMID 37185961, PMID 41343184, PMID 30548235, PMID 31420360, PMID 38421243, PMID 40966692, PMID 10661346, PMID 11917283, PMID 12694838, PMID 14529764, PMID 14967428, PMID 15234047, PMID 15590164, PMID 15735120, PMID 15800308, PMID 15936549, PMID 16015544, PMID 16198508, PMID 16425991, PMID 18455325, PMID 18501528, PMID 18779504, PMID 18976072, PMID 19577865, PMID 19636002, PMID 19858383, PMID 19910132, PMID 20207506, PMID 20530316, PMID 20598811, PMID 21377288, PMID 21414514, PMID 21507583, PMID 21941283, PMID 22204724, PMID 22252927, PMID 22342302, PMID 22543211, PMID 22633552, PMID 22673726, PMID 22851558, PMID 23219660, PMID 23261356, PMID 23477890, PMID 23725999, PMID 23726000, PMID 23823157, PMID 23956241, PMID 23984897, PMID 24101040
U10CA180868 (143), U10CA027469 (33), U10CA021661 (22), UG1CA189867 (14), U10CA012027 (3), U10CA180830 (3), P30CA138292 (2), 2016 (1), 75N91019C00054-0-9999-1 (1), P50CA083639 (1), P50CA098258 (1), P50CA127001 (1), R01CA279472 (1), R01CA282416 (1), U10CA037422 (1)