591 completed, 186 terminated, 179 recruiting, 129 unknown. 1290 Phase 2, 289 Phase 1, 38 Phase 3.
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients Aminolevulinic acid hydrochloride - Pediatric Brain Tumor | Phase 2 | Not yet recruiting | Costas Hadjipanayis | 20 | 2027-08-01 | 2026-10-07 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas IDH1-vac, IS-vac, Temozolomide (TMZ) - Astrocytoma, IDH-Mutant, Grade 3, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Not yet recruiting | German Cancer Research Center | 216 | 2027-02-01 | 2026-10-22 |
| Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults Mirdametinib - LGCMN, Large and Giant Congenital Melanocytic Nevi | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 15 | 2027-01-04 | 2026-10-29 |
| Ceritinib Treatment for Recurrent Meningiomas Ceritinib - Recurrent Meningioma, Grade I and Grade II | Phase 2 | Not yet recruiting | Kevin Petrecca | 10 | 2027-01-01 | 2026-10-23 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| A Study of ONC201 for Refractory Meningioma ONC201 - Meningioma, Refractory Meningioma | Phase 2 | Withdrawn | University of Nebraska | 2026-12-01 | 2026-01-26 | |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera - Brain Tumor | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-12-01 | 2026-09-29 |
| Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2 | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 20 | 2026-12-01 | 2026-10-28 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| Molecularly Stratified Trial for Newly Diagnosed Infant-Type Hemispheric Glioma Alectinib, Entrectinib, Surgery - Infant-Type Hemispheric Glioma | Phase 2 | Not yet recruiting | St. Jude Children's Research Hospital | 50 | 2026-11-01 | 2026-11-04 |
| A Study to Evaluate the Efficacy and Safety of Maintenance Ublituximab Following Induction With Efgartigimod Administration in Participants With Myasthenia Gravis (MG) Ublituximab, Placebo - Myasthenia Gravis | Phase 2 | Recruiting | TG Therapeutics, Inc. | 120 | 2026-11-01 | 2026-10-29 |
| Lemborexant on Perioperative Sleep Quality in Patients With Brain Tumor Undergoing Surgery Lemborexant 5 mg, placebo - Brain Neoplasms, Sleep Initiation and Maintenance Disorders | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 112 | 2026-11-01 | 2026-10-29 |
| Pharmacoscopy for Patients With Refractory Primary Brain Tumors Pharmacoscopy 1.0 - Brain (Nervous System) Cancers, Glioblastoma | Phase 2 | Recruiting | University of Zurich | 40 | 2026-09-11 | 2026-09-21 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
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Brain Neoplasms (783) · Glioblastoma (348) · Central Nervous System Neoplasms (297) · Glioma (220) · Gliosarcoma (200) · Astrocytoma (175) · Oligodendroglioma (122) · Carcinoma, Non-Small-Cell Lung (108) · Breast Neoplasms (90) · Meningioma (79) · Sarcoma (73) · Melanoma (67) · Neoplasm Metastasis (67) · Medulloblastoma (65) · Ependymoma (62)
Nervous System Diseases (1284) · Neoplasms (1228) · Neoplasms by Site (1208) · Central Nervous System Diseases (871) · Brain Diseases (858) · Central Nervous System Neoplasms (812) · Neoplasms by Histologic Type (796) · Neoplasms, Nerve Tissue (751) · Neoplasms, Germ Cell and Embryonal (635) · Neuroectodermal Tumors (634) · Neoplasms, Glandular and Epithelial (581) · Neoplasms, Neuroepithelial (546) · Glioma (304) · Astrocytoma (224)
Temozolomide (157) · Radiotherapy (114) · Bevacizumab (93) · Carboplatin (56) · Radiosurgery (46) · Etoposide (40) · Cyclophosphamide (39) · Cisplatin (36) · Filgrastim (33) · Irinotecan (33) · pembrolizumab (33) · Magnetic Resonance Spectroscopy (30) · Erlotinib Hydrochloride (28) · Nivolumab (28) · Vincristine (28)
National Cancer Institute (NCI) (107) · M.D. Anderson Cancer Center (42) · Duke University (40) · Memorial Sloan Kettering Cancer Center (33) · European Organisation for Research and Treatment of Cancer - EORTC (20) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (20) · Novartis Pharmaceuticals (19) · Alliance for Clinical Trials in Oncology (15) · Children's Oncology Group (15) · Radiation Therapy Oncology Group (15) · St. Jude Children's Research Hospital (14) · Fudan University (12) · Massachusetts General Hospital (12) · Dana-Farber Cancer Institute (11) · Jonsson Comprehensive Cancer Center (11)
United States (853) · Canada (128) · China (124) · France (99) · Spain (75) · Germany (73) · Italy (70) · United Kingdom (69) · Australia (64) · Netherlands (55) · Belgium (50) · Switzerland (42) · Denmark (30) · Poland (30) · South Korea (29)
Henry S. Friedman, MD (11) · David A. Reardon, MD (7) · Stanislaw R. Burzynski, MD, PhD (7) · David Peereboom, MD (5) · Edward G. Shaw, MD (5) · Jan C. Buckner, MD (5) · Jonathan L. Finlay, MB, ChB (5) · Stuart A. Grossman, MD (5) · Thomas Kaley, MD (5) · Amar Gajjar, MD (4) · Betty Lawrence (4) · Brigitte C Widemann, M.D. (4)
PMID 31401903, PMID 16200343, PMID 17705175, PMID 21865400, PMID 23243055, PMID 25098701, PMID 25303679, PMID 25789053, PMID 26148750, PMID 27243238, PMID 28592387, PMID 30670498, PMID 31587882, PMID 31838007, PMID 33067126, PMID 33362722, PMID 34081125, PMID 34331515, PMID 35350948, PMID 36884302, PMID 39024777, PMID 40086048, PMID 41213248, PMID 10501910, PMID 10655437, PMID 11452123, PMID 11705489, PMID 11772431, PMID 11835236, PMID 11907388, PMID 11937316, PMID 12177103, PMID 12434281, PMID 12525516, PMID 12528778, PMID 12649108, PMID 12675312, PMID 12749708, PMID 12750523, PMID 12829671, PMID 12957454, PMID 13680158, PMID 1408229, PMID 14506149, PMID 14586216, PMID 14625709, PMID 14670747, PMID 14769135, PMID 14769136, PMID 14769138
U10CA180886 (17), 2023 (14), U10CA098543 (11), 2018 (9), 2019 (9), 2025 (9), U01CA062399 (9), U01CA062475 (9), 2014 (8), 2015 (8), P30CA008748 (8), U10CA025224 (8), 2009 (7), 2017 (7), P30CA033572 (7)