41 completed, 5 terminated, 2 active not recruiting, 2 recruiting. 53 Phase 1, 13 Phase 2.
Follow Nausea: new trials by email Literature Review of Nausea trials Research Report on Nausea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults NS003 Ondansetron HCl microspheres powder for nasal application, Ondansetron Solution for IV infusion 8mg - Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV) | Phase 1 | Recruiting | Nasus Pharma | 12 | 2026-09-15 | 2026-10-09 |
| Hyperemesis Gravidarum Risk Reduction With Metformin Metformin Extended Release Oral Tablet - Hyperemesis Gravidarum | Phase 1 / Phase 2 | Recruiting | University of Southern California | 224 | 2026-07-13 | 2026-07-22 |
| Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Ondansetron (Zofran), chewing gum, Ondansetron + Chewing gum - Postoperative Nausea and Vomiting (PONV) | Phase 1 | Active not recruiting | Makassed General Hospital | 90 | 2025-08-22 | 2025-10-01 |
| The Relationship Between NLR and PONV and ESPB Erector Spinae Plane Block, 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB). - Erector Spinae Plane Block, Neutrophil to Lymphocyte Ratio | Phase 1 | Not yet recruiting | Qianfoshan Hospital | 220 | 2025-08-01 | 2025-07-29 |
| Phase I PK and Safety Study of Ondansetron Inhalation Powder LPI-1503, Matching Placebo of LPI-1503, IV Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Luxena Pharmaceuticals, Inc. | 24 | 2025-03-13 | 2026-03-27 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive - Postoperative Pain, Nausea and Vomiting, Postoperative | Phase 1 / Phase 2 | Active not recruiting | University of Arizona | 100 | 2024-10-10 | 2026-02-13 |
| Pharmacokinetics and Bioequivalence of Doxylamine+Pyridoxine and Diclectin Under Fed Conditions in Healthy Volunteers Doxylamine + Pyridoxine, Diclectin - Nausea | Phase 1 | Completed | Valenta Pharm JSC | 28 | 2024-02-27 | 2025-07-11 |
| Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation Glycopyrrolate, Anisodamine - Nausea and Vomiting | Phase 1 / Phase 2 | Completed | Jie Chen | 130 | 2023-10-01 | 2024-09-05 |
| A Clinical Study to Evaluate Cyclopofol Injection for the Prevention of Postoperative Nausea and Vomiting Heptaflurane combined Cyclophenol, Heptaflurane, Cyclophenol - Nausea and Vomiting | Phase 1 | Unknown | Mengchang Yang | 300 | 2023-08-02 | 2023-07-27 |
| Endeavor to Stop Nausea/Vomiting Associated With Pregnancy (E-SNAP) Mirtazapine - Pregnancy, Severe Nausea and Vomiting | Phase 1 / Phase 2 | Withdrawn | Northwestern University | 2022-06-13 | 2024-12-11 | |
| Use of Aromatherapy in Conjunction With Physical/Occupational Therapy in an Acute Care Setting Lavender Oil, Mandarin Oil, Peppermint oil - Suffering, Physical, Nausea | Phase 1 | Completed | The University of Texas Health Science Center at San Antonio | 165 | 2022-05-16 | 2026-06-16 |
| A Study of TAK-951 in Participants With Cyclic Vomiting Syndrome (CVS) TAK-951, TAK-951 Placebo - Nausea and Vomitting | Phase 1 | Terminated | Takeda | 1 | 2022-03-02 | 2025-07-02 |
| Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children Dexamethasone, Ondansetron, Dexmedetomidine - Postoperative Nausea and Vomiting, Post Operative Pain | Phase 1 | Completed | Tanta University | 4 | 2021-10-27 | 2022-04-05 |
| Study to Assess Bioequivalence and Adhesion Properties Between Two Granisetron Transdermal Patches. Sancuso - Part 1, Sancuso - Part 2 - Healthy Volunteers | Phase 1 | Completed | Kyowa Kirin, Inc. | 134 | 2021-07-06 | 2024-06-14 |
| Olanzapine for the Prevention of Postoperative Nausea and Vomiting Placebo, 5 mg Olanzapine Tablets, 10 mg Olanzapine Tablets - Postoperative Nausea | Phase 1 / Phase 2 | Completed | Amani Hassan Abdel-Wahab | 132 | 2021-03-15 | 2023-03-09 |
| The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy Cannabidiol - Lean Body Mass, Cannabis | Phase 1 | Completed | University of Copenhagen | 32 | 2020-12-01 | 2023-07-24 |
| Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran Bremelanotide, Zofran, Placebo - Nausea | Phase 1 | Completed | AMAG Pharmaceuticals, Inc. | 228 | 2019-06-17 | 2022-04-04 |
| Study of APD421 With and Without Ondansetron APD421, Placebo, Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Acacia Pharma Ltd | 30 | 2018-07-17 | 2018-10-01 |
| Study of Granisetron Hydrochloride Nasal Spray (GNS) in Healthy Volunteers GNS Spray 0.5mg, GNS Spray 1.0mg, GNS Spray 2.0mg - Cancer | Phase 1 | Completed | Maxinase Life Sciences Ltd. | 50 | 2015-09-01 | 2016-01-08 |
Showing 20 of 53. Sign in to see all of them.
Vomiting (32) · Postoperative Nausea and Vomiting (15) · Pain (4) · Anorexia (2) · Breast Neoplasms (2) · Gastroparesis (2) · Hyperemesis Gravidarum (2) · Neoplasms (2) · Pain, Postoperative (2) · Abdominal Pain (1) · Appetitive Behavior (1) · Brain Neoplasms (1) · Cachexia (1) · Constipation (1)
Pathological Conditions, Signs and Symptoms (53) · Signs and Symptoms (53) · Signs and Symptoms, Digestive (53) · Pathologic Processes (15) · Postoperative Complications (15) · Vomiting (11) · Neurologic Manifestations (9) · Neoplasms (4) · Neoplasms by Site (4) · Nervous System Diseases (4) · Body Weight (3) · Digestive System Diseases (3) · Mental Disorders (3) · Pain (3)
Ondansetron (15) · casopitant (8) · Aprepitant (3) · Dexamethasone (3) · Granisetron (3) · Cyclophosphamide (2) · Dexmedetomidine (2) · Ketoconazole (2) · Tablets (2) · fosaprepitant (2) · halofantrine (2) · Acupressure (1) · Acupuncture Therapy (1) · Cannabidiol (1) · Chewing Gum (1)
GlaxoSmithKline (10) · Forest Laboratories (3) · Merck Sharp & Dohme LLC (2) · Sandoz (2) · University of Southern California (2) · AMAG Pharmaceuticals, Inc. (1) · Acacia Pharma Ltd (1) · Amani Hassan Abdel-Wahab (1) · Charleston Laboratories, Inc (1) · Duke University (1) · Jie Chen (1) · Johns Hopkins University (1) · Kyowa Kirin, Inc. (1) · Luxena Pharmaceuticals, Inc. (1) · M.D. Anderson Cancer Center (1)
United States (28) · Canada (4) · China (2) · Brazil (1) · Denmark (1) · Egypt (1) · India (1) · Israel (1) · Lebanon (1) · Mexico (1) · New Zealand (1) · Pakistan (1) · Russia (1) · Saudi Arabia (1) · Spain (1)
Eric Sicard, M.D. (3) · Soran Hong, M.D. (2) · Agop Y. Bedikian, MD (1) · Agustin Garcia (1) · Amani H Abdel-wahab, MD (1) · Anh D Dang, PhD (1) · Bernard P Schachtel, M.D (1) · Bianca Gonzales, OTR, CNT, EdD, MOT (1) · Bruno Gagnon, MD, MSC (1) · Christine M. Walko, PharmD, BCOP (1) · David R. Drover, MD (1)
PMID 17513629, PMID 19205754, PMID 19617379, PMID 20220045, PMID 20579837, PMID 22096279, PMID 22245954, PMID 22520120, PMID 2286697, PMID 23904932, PMID 25670522, PMID 25885838, PMID 26160357, PMID 31303716, PMID 31862004, PMID 31913911, PMID 32839657, PMID 40856942, PMID 40950965
2008 (1), P30CA016086 (1), P30CA069533 (1), R21HD105101 (1), R43AT004489 (1)