56 completed, 20 recruiting, 16 unknown, 6 terminated. 38 Not applicable, 7 Phase 2, 6 Phase 4, 4 Phase 1, 3 Phase 3.
Follow Iris Diseases: new trials by email Literature Review of Iris Diseases trials Research Report on Iris Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Insulin for Glaucoma (TING2) EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month) - Open Angle Glaucoma, Primary Open Angle Glaucoma | Phase 1 / Phase 2 | Enrolling by invitation | Stanford University | 90 | 2026-09-10 | 2026-10-13 |
| Pupil Size and Choroidal Thickness Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients tamsulosin 0.4mg, Silodosin 8 mg - Benign Prostatic Hyperplasia, Silodosin | Phase 4 | Not yet recruiting | Mohsen Pourazizi | 40 | 2026-08-01 | 2026-08-03 |
| Iris Structural Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients tamsulosin 0.4mg, Silodosin 8 mg - Benign Prostatic Hyperplasia, Tamsulosin | Phase 4 | Not yet recruiting | Mohsen Pourazizi | 40 | 2026-08-01 | 2026-08-03 |
| Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome Pseudoexfoliation Syndrome, Cataract | Not yet recruiting | Kata Culina | 70 | 2026-07-20 | 2026-07-23 | |
| Corneal Biomechanics and Surgically Induced Astigmatism in Pseudoexfoliation Syndrome phacoemulsification cataract surgery - Pseudoexfoliation Syndrome, Cataract | Recruiting | Kata Culina | 70 | 2026-07-20 | 2026-08-18 | |
| The Safety and Efficacy of Direct SLT in Pseudoexfoliation Glaucoma Direct selective laser trabeculoplasty - Pseudoexfoliation Glaucoma | Not applicable | Not yet recruiting | Vance Thompson Vision | 40 | 2026-03-01 | 2026-02-10 |
| Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma iStent infinite trabecular micro-bypass system model iS3, iDose TR (Travoprost intracameral Implant) 75mcg - Open Angle Glaucoma, Pigmentary Glaucoma | Phase 4 | Recruiting | Jonathon Myers | 20 | 2026-01-05 | 2025-11-14 |
| Pseudoexfoliation and Carpal Tunnel Study Pseudoexfoliation Syndrome, Carpal Tunnel Syndrome (CTS) | Completed | Ankara Training and Research Hospital | 159 | 2025-05-01 | 2026-04-17 | |
| Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma Transcorneal electrical stimulation (TES) with the OkuStim 2 System - Glaucoma, Primary Open Angle Glaucoma | Not applicable | Recruiting | Okuvision GmbH | 50 | 2025-04-02 | 2026-03-12 |
| Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients Vitamin B-mix, Standard Care - Open-angle Glaucoma, Pseudoexfoliation Glaucoma | Not applicable | Recruiting | Karolinska Institutet | 80 | 2025-03-31 | 2025-04-29 |
| Physical Activity and Community EmPOWERment Project PACE Program - Intellectual Disability, Neurodevelopmental Disorders | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 376 | 2025-01-10 | 2026-02-23 |
| Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation Pentacam-AXL, HD Analyzer, Corvis ST - Pseudoexfoliation Syndrome, Biomechanical Parameters | Recruiting | Aristotle University Of Thessaloniki | 86 | 2024-12-13 | 2024-12-27 | |
| The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome. optical coherence tomography - Pseudoexfoliation Syndrome | Not yet recruiting | Assiut University | 33 | 2024-12-01 | 2024-09-19 | |
| Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt Suprachoroidal silicone tube (SST) shunt - Glaucoma, Open Angle Glaucoma (OAG) | Recruiting | Davinci LTD | 66 | 2024-11-08 | 2024-11-15 | |
| Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations Blood sampling - Eye Abnormalities | Recruiting | University Hospital, Toulouse | 20 | 2024-11-05 | 2026-03-18 | |
| National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases Inherited Ophthalmic Diseases, Hypopigmentation Disorder | Recruiting | National Eye Institute (NEI) | 1000 | 2024-07-12 | 2026-06-09 | |
| Electron Microscopic Examination of Iris Tissue in Buphthalmos Combined trabeculotomy trabeculectomy with mitomycin C - Iris Diseases | Not applicable | Completed | Assiut University | 20 | 2024-06-01 | 2025-06-24 |
| Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies Rare Diseases, Aniridia | Unknown | IRCCS Ospedale San Raffaele | 274 | 2024-05-01 | 2024-05-14 | |
| XEN Glaucoma Gel Stent Versus Trabeculectomy surgery - Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma | Not applicable | Recruiting | Prof. Dr. Herbert Reitsamer | 196 | 2023-12-20 | 2025-06-03 |
| Treatment of LSCD With DM transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD - Limbal Stem-cell Deficiency, Congenital Aniridia | Phase 1 | Completed | University of Minnesota | 19 | 2023-11-30 | 2026-01-08 |
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Exfoliation Syndrome (72) · Glaucoma, Open-Angle (37) · Aniridia (22) · Glaucoma (22) · Cataract (15) · Ocular Hypertension (14) · Iritis (7) · Uveitis (5) · Glaucoma, Angle-Closure (4) · Limbal Stem Cell Deficiency (4) · Axenfeld-Rieger syndrome (3) · Glaucoma, Neovascular (3) · Hydrophthalmos (3) · Iridocorneal Endothelial Syndrome (3)
Eye Diseases (112) · Uveal Diseases (112) · Ocular Hypertension (32) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (29) · Eye Abnormalities (26) · Genetic Diseases, Inborn (26) · Eye Diseases, Hereditary (25) · Congenital Abnormalities (24) · Glaucoma (24) · Lens Diseases (16) · Pathological Conditions, Signs and Symptoms (15) · Corneal Diseases (12) · Skin and Connective Tissue Diseases (10) · Signs and Symptoms (9)
Phacoemulsification (5) · Blood Specimen Collection (3) · Cataract Extraction (2) · Descemet Stripping Endothelial Keratoplasty (2) · Lubricant Eye Drops (2) · Mitomycin (2) · Surveys and Questionnaires (2) · Tamsulosin (2) · Timolol (2) · Travoprost (2) · ataluren (2) · silodosin (2) · 1(beta)-D-arabinofuranosylcytosine-5'-diphosphate prednisolone (1) · AR-12286 (1) · Biopsy, Fine-Needle (1)
National Eye Institute (NEI) (7) · Assiut University (6) · Aristotle University Of Thessaloniki (5) · Medical University of Vienna (4) · St. Erik Eye Hospital (4) · Vastra Gotaland Region (3) · Davinci LTD (2) · General Hospital Sveti Duh (2) · Kata Culina (2) · Mohsen Pourazizi (2) · Nova Scotia Health Authority (2) · PTC Therapeutics (2) · University of Minnesota (2) · Wills Eye (2) · Xerencia de Xestión Integrada de Ferrol (2)
United States (32) · Sweden (9) · Austria (8) · France (6) · Canada (5) · Greece (5) · Egypt (4) · Germany (4) · Croatia (3) · Turkey (Türkiye) (3) · Finland (2) · Georgia (2) · Italy (2) · Spain (2) · Switzerland (2)
Marcelo Ayala, MD, PhD (3) · Tobias Dahlgren, MD (3) · Enping Chen, MD Ph D (2) · Alejandra Daruich, MD, PhD (1) · Alexandra Wexler, Dr (1) · Anastasios G Konstas, MD, PhD (1) · Andrew C Crichton (1) · Antonios T Dimopoulos, MD (1) · Austin Bach, DO (1) · Brian P Brooks, M.D. (1) · Brianne R Tomaszewski, PhD., MPH (1) · Carina Koppen, MD, PhD (1) · Changwon Kee, M.D., PhD (1)
PMID 11152054, PMID 14078870, PMID 14078872, PMID 18552979, PMID 18648524, PMID 18812117, PMID 19485285, PMID 19664754, PMID 19781456, PMID 19875170, PMID 20166622, PMID 20465801, PMID 21099412, PMID 21183511, PMID 21872938, PMID 21993468, PMID 22218143, PMID 22705345, PMID 22710494, PMID 22710497, PMID 23635858, PMID 24252821, PMID 24417895, PMID 24452215, PMID 24488132, PMID 24782475, PMID 24794283, PMID 24957432, PMID 26050537, PMID 26096520, PMID 26603402, PMID 26764881, PMID 26983976, PMID 27108095, PMID 27158810, PMID 27373394, PMID 27560030, PMID 28749899, PMID 29267575, PMID 29515428, PMID 29525615, PMID 29718281, PMID 29731147, PMID 30041739, PMID 30488265, PMID 30855519, PMID 32705337, PMID 32890108, PMID 33591041, PMID 35943114
2023 (1), P01CA034936 (1), R01AG076678 (1), R01EY028755 (1), UL1TR001082 (1)