6 completed, 1 recruiting, 1 unknown. 4 Phase 3, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 4 |
| Not applicable | 3 | Completed 2, Unknown 1 |
Follow Manic Episode: new trials by email Literature Review of Manic Episode trials Research Report on Manic Episode
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LHC-CIDI-5 in Hong Kong CIDI-5, LHC-CIDI-5 - Major Depressive Episode (MDE), Major Depressive Disorder (MDD) | Recruiting | The University of Hong Kong | 2500 | 2025-01-18 | 2026-03-10 | |
| Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS (R)-3-hydroxybutyl (R)-3-hydroxybutyrate), Maltodextrin, Fructose, Pectin, Sodium alginate, Sodium chloride - Schizophrenia and Related Disorders, Psychosis | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 28 | 2024-12-01 | 2026-04-27 |
| A Study of Spoken Language in Mania Research interview - Manic Episode, Bipolar I Disorder | Not applicable | Completed | Mayo Clinic | 17 | 2023-04-27 | 2026-03-19 |
| Effect of tDCS Combined With Pharmacological Treatments for Bipolar Mania active group of tDCS, sham group of tDCS - Manic Episode | Not applicable | Unknown | Dongbin Lyu | 70 | 2022-10-01 | 2022-11-18 |
| A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes, Associated With Bipolar I Disorder Brexpiprazole, Placebo - Bipolar I Disorder, Manic Episode | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 333 | 2017-09-19 | 2020-02-11 |
| A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I Disorder Brexpiprazole, Placebo - Bipolar I Disorder, Manic Episode | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 322 | 2017-09-14 | 2020-02-10 |
| A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder Risperidone, oral tablets - Bipolar Disorder, Manic Episode | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 291 | 2001-03-01 | 2011-01-14 |
| A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder Risperidone, oral tablets - Bipolar Disorders, Manic Episode | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 267 | 2000-12-01 | 2011-01-14 |
Mania (8) · Bipolar Disorder (3) · Alcoholism (1) · Bipolar and Related Disorders (1) · Depressive Disorder, Major (1) · Disruptive, Impulse Control, and Conduct Disorders (1) · Generalized Anxiety Disorder (1) · Mental Disorders (1) · Obsessive-Compulsive Disorder (1) · Panic Disorder (1) · Psychotic Disorders (1) · Schizophrenia (1) · Self-Injurious Behavior (1) · Stress Disorders, Post-Traumatic (1) · Substance-Related Disorders (1)
Nervous System Diseases (8) · Neurobehavioral Manifestations (8) · Neurologic Manifestations (8) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Mood Disorders (4) · Bipolar and Related Disorders (3) · Mental Disorders (3) · Alcohol-Related Disorders (1) · Anxiety Disorders (1) · Behavior (1) · Behavioral Symptoms (1) · Chemically-Induced Disorders (1) · Depressive Disorder (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1)
Risperidone (2) · brexpiprazole (2) · (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (1) · Alginates (1) · Fructose (1) · Pectins (1) · Sodium Chloride (1) · maltodextrin (1)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Otsuka Pharmaceutical Development & Commercialization, Inc. (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Dongbin Lyu (1) · Mayo Clinic (1) · The University of Hong Kong (1)
United States (3) · Bulgaria (1) · China (1) · Croatia (1) · Hong Kong (1) · Netherlands (1) · Poland (1) · Serbia (1) · Ukraine (1)
Matthew Leoni, M.D. (2) · Dongbin Lyu, MBBS (1) · Karin Huizer, MD/PhD (1) · Mark Frye, MD (1) · Michael Y. Ni, MD (1)