18 completed, 4 unknown, 2 terminated. 12 Not applicable, 5 Phase 2, 3 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 10, Terminated 1, Unknown 1 |
| Phase 2 | 5 | Completed 5 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Lung Injury, Acute: new trials by email Literature Review of Lung Injury, Acute trials Research Report on Lung Injury, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction 10 PEEP, ZEEP, 5PEEP - Lung Injury, Acute | Not applicable | Completed | Fudan University | 120 | 2025-03-28 | 2025-05-29 |
| Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery Dexmedetomidine Hydrochloride, Placebo - Surgery-Complications, Respiratory Complication | Not applicable | Completed | Brigham and Women's Hospital | 100 | 2024-08-01 | 2025-11-21 |
| Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air 0.070 ppm ozone concentration, Clean air (0.0 ppm ozone) - Lung Injury, Acute, Symptoms and Signs | Phase 1 | Unknown | Martin W. Case | 60 | 2022-10-13 | 2023-01-11 |
| Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass blood cell analysis, blood gas surveillance, chest radiograph and echocardiography - Hypoxemia, ARDS | Not applicable | Completed | Zhuan Zhang | 100 | 2022-02-01 | 2022-12-12 |
| Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass blood cell analysis, blood gas surveillance, chest radiograph and echocardiography - Lung Injury, Acute | Not applicable | Completed | Yangzhou University | 100 | 2022-02-01 | 2022-11-14 |
| Features of Regional Perfusion of Lung Consolidation Ultrasound - Lung Injury, Acute, Ultrasound Therapy; Complications | Unknown | Peking Union Medical College Hospital | 200 | 2022-01-01 | 2022-12-13 | |
| Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Nebulised heparin - Covid19, ARDS, Human | Phase 1 / Phase 2 | Completed | University College Hospital Galway | 40 | 2020-12-23 | 2024-07-24 |
| SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) L-ascorbic acid, Placebo - COVID-19, Lung Injury, Acute | Phase 2 | Completed | Virginia Commonwealth University | 47 | 2020-12-18 | 2024-04-04 |
| Tomographic Findings in COVID-19 and Influenza H1N1 Lung CT - Covid19, Influenza A H1N1 | Unknown | Universidad de Guanajuato | 200 | 2020-08-15 | 2021-05-03 | |
| Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants regular lung recruitment - High Frequency Oscillation Ventilation, Extreme Prematurity | Not applicable | Completed | Medical University of Vienna | 36 | 2020-02-25 | 2026-08-06 |
| Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients PEEP ARDSnet, PEEP LRM - ARDS, Human, Lung Injury, Acute | Not applicable | Terminated | Massachusetts General Hospital | 2 | 2019-06-19 | 2025-12-19 |
| Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery Lidocaine, Remifentanil - Lung Diseases, Lung Inflammation | Phase 4 | Completed | Francisco Andres de la Gala | 156 | 2019-01-28 | 2021-08-25 |
| Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO Ultra-protective ventilator settings, Standard ventilator settings - ARDS, Acute Lung Injury | Not applicable | Completed | Medical University of Vienna | 44 | 2018-11-06 | 2025-04-17 |
| Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg Mechanical ventilation - Lung Injury, Acute, Ventilator-Induced Lung Injury | Not applicable | Completed | Kocaeli University | 32 | 2018-10-15 | 2020-03-05 |
| Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients Obstetric Complication, Lung Injury, Acute | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 168 | 2018-07-08 | 2019-04-25 | |
| Lung Protection and Pediatric Cardiac Surgery cardiopulmonary bypass - Lung Injury, Acute | Not applicable | Completed | Assiut University | 68 | 2017-01-01 | 2018-12-04 |
| a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries inverse ratio ventilation - Lung Injury, Acute | Not applicable | Unknown | All India Institute of Medical Sciences, Rishikesh | 128 | 2016-12-01 | 2018-08-20 |
| The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury Dose 1 GSK2586881, Dose 2 GSK2586881, Dose 3 GSK2586881 - Lung Injury, Acute | Phase 2 | Completed | GlaxoSmithKline | 44 | 2012-09-01 | 2017-09-28 |
| A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers Saline, GW328267X (total dose of 12mcg), GW328267X (total dose of 40mcg) - Lung Injury, Acute | Phase 1 | Completed | GlaxoSmithKline | 3 | 2011-11-22 | 2017-06-12 |
| SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS SB-681323 Intravenous 3mg, SB-681323 Intravenous 7.5 mg, SB-681323 Intravenous 7.5mg - Lung Injury, Acute | Phase 2 | Completed | GlaxoSmithKline | 77 | 2009-10-16 | 2017-10-18 |
Showing 20 of 24. Sign in to see all of them.
Acute Lung Injury (24) · Respiratory Distress Syndrome (8) · COVID-19 (3) · Lung Diseases (3) · Lung Injury (2) · Respiratory Aspiration (2) · Bronchiolitis Obliterans (1) · Heart Failure (1) · Hypoxia (1) · Inflammation (1) · Lung Neoplasms (1) · Motor Activity (1) · Orthomyxoviridae Infections (1) · Pneumonia (1) · Postoperative Complications (1)
Respiratory Tract Diseases (23) · Lung Injury (22) · Lung Diseases (21) · Respiration Disorders (10) · Pathological Conditions, Signs and Symptoms (5) · Infections (4) · Pathologic Processes (4) · Respiratory Tract Infections (4) · Coronaviridae Infections (3) · Coronavirus Infections (3) · Nidovirales Infections (3) · Pneumonia (3) · Pneumonia, Viral (3) · RNA Virus Infections (3) · Virus Diseases (3)
Echocardiography (2) · Sodium Chloride (2) · Ascorbic Acid (1) · Cardiopulmonary Bypass (1) · Control Groups (1) · Dexmedetomidine (1) · Etanercept (1) · Ipratropium (1) · Lidocaine (1) · Remifentanil (1) · Respiration, Artificial (1) · Ultrasonography (1)
GlaxoSmithKline (3) · Medical University of Vienna (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · All India Institute of Medical Sciences, Rishikesh (1) · Assiut University (1) · Brigham and Women's Hospital (1) · Francisco Andres de la Gala (1) · Fudan University (1) · Kocaeli University (1) · LUN WEI LIU (1) · Martin W. Case (1) · Massachusetts General Hospital (1) · Peking Union Medical College Hospital (1) · Universidad de Guanajuato (1) · University College Hospital Galway (1)
United States (8) · China (4) · Austria (2) · Canada (1) · Egypt (1) · Ireland (1) · Mexico (1) · Sierra Leone (1) · Spain (1) · Switzerland (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Andy Ghio, M.D. (1) · Anna de Nicolo, MD, PhD (1) · Brian Davis, MD (1) · Christoph Ellenberger, MD (1) · Eva Henciles, MD (1) · Francisco de la Gala, MD PhD (1) · Gregory A Yanik, MD (1) · Huaiwu He, MD (1) · Jaime D Mondragon, M.D. (1) · John A Barwise, M.D. (1) · John Laffey (1) · Jun Zhang, Professor (1) · Lorenzo Berra, MD (1)
PMID 10835058, PMID 10945393, PMID 16763218, PMID 17989152, PMID 19364558, PMID 19887665, PMID 20160606, PMID 21435708, PMID 22155140, PMID 24693893, PMID 26102252, PMID 27745747, PMID 28802696, PMID 28877748, PMID 29680828, PMID 29757717, PMID 30566567, PMID 31694684, PMID 32031570, PMID 32083985, PMID 32109013, PMID 32155105, PMID 32399710, PMID 36104785, PMID 36465445, PMID 36503480, PMID 40011857, PMID 40897588