14 completed, 7 recruiting, 4 unknown, 2 not yet recruiting. 30 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 30 | Completed 14, Recruiting 7, Unknown 4, Not yet recruiting 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
Follow Lower Limb Amputation: new trials by email Literature Review of Lower Limb Amputation trials Research Report on Lower Limb Amputation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Footwear on Gait in Unilateral Transtibial Amputees Own Footwear, Oxford Shoe, Walking/Running Shoe - Transtibial Amputation, Lower Limb Amputation | Not applicable | Recruiting | University of Salford | 15 | 2026-11-03 | 2026-10-23 |
| Acute Post-Amputation Pain Management After Combat-Related Lower Limb Injury Continuous Peripheral Nerve Blocks, Peripheral Nerve Cryoablation, Standard multimodal analgesia - Postamputation Pain, Lower Limb Amputation | Not applicable | Not yet recruiting | Kharkiv National Medical University | 36 | 2026-10-10 | 2026-10-07 |
| Exploratory Functional Assessment After Lower Limb Amputation: Locomotion, Balance, Energy Performance and Strategies for Adapting to Orthopaedic Devices Walk tests, Functional testing, Balance analysis - Lower Limb Amputation | Not applicable | Recruiting | Centre Hospitalier Universitaire Dijon | 100 | 2026-09-18 | 2026-09-28 |
| Dual-Task Balance Training in Traumatic Lower-Limb Prosthesis Users Dual-Task Balance Training, Standard Rehabilitation - Lower Limb Amputation, Prosthesis Users | Not applicable | Recruiting | Al-Azhar University - Gaza | 63 | 2026-07-08 | 2026-07-23 |
| Development of a Performance Model for Amputee Football Players Gince Intelligence Game-Based Exercise Program, Routine Training Group - Cognitive Games, Sports Performance | Not applicable | Recruiting | Tarsus University | 20 | 2026-06-26 | 2026-09-25 |
| Muscle Strength Training in Lower Limb Amputee Patients Muscle strengh training, Resistence training - Lower Limb Amputation | Not applicable | Not yet recruiting | University of Gran Rosario | 18 | 2025-11-30 | 2025-12-03 |
| Effect of Balance Exercises on Performance in Amputee Football Players Balance and Trunk Stabilization Exercise Program - Lower Limb Amputation, Balance Impairment | Not applicable | Completed | Istanbul Rumeli University | 20 | 2025-10-02 | 2026-07-20 |
| Intrathecal Dexmedetomidine and Acute Neuropathic Pain After Lower Limb Amputation Hyperbaric Bupivacaine plus Saline, Hyperbaric Bupivacaine plus Dexmedetomidine - Phantom Limb Pain, Neuropathic Pain | Not applicable | Completed | Universidad Juárez Autónoma de Tabasco | 30 | 2025-09-30 | 2026-10-21 |
| Uses of Phantom Sensations Induced by Global and Local Modifications of the Prosthetic Socket as Somatosensory Feedback During Walking in Lower Limb Amputees Gait analysis, Mapping of referred sensations., Evaluation of the effects of socket modifications on phantom sensations and walking - Lower Limb Amputation | Not applicable | Recruiting | Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est | 248 | 2024-09-16 | 2026-11-03 |
| Effect of PNF-Based Upper Extremity Strengthening With Core Stabilization on Fitness in Amputee Football Players Training, Control Group - Amputation, Lower Limb Amputation | Not applicable | Active not recruiting | Uskudar University | 14 | 2024-09-01 | 2026-04-01 |
| Epidural Oxycodone for Pain Management for Lower Limb Amputation Oxycodone, Bupivacaine - Epidural, Oxycodone | Not applicable | Unknown | Kafrelsheikh University | 40 | 2024-02-24 | 2024-02-28 |
| Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only - Phantom Limb Pain After Amputation, Lower Limb Amputation | Not applicable | Completed | VA Office of Research and Development | 20 | 2023-07-01 | 2026-01-16 |
| Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project Multidisciplinary Conventional and Technology-based Rehabilitation, Multidisciplinary Conventional Rehabilitation - Lower Limb Amputation, Prosthesis User | Not applicable | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 70 | 2023-06-01 | 2026-02-23 |
| Perineural Methylene Blue Infusion in Lower Limb Amputation Surgery Bupivacaine methylene blue, bupivacaine saline - Perineural, Methylene Blue | Not applicable | Recruiting | Tanta University | 72 | 2023-05-01 | 2026-07-06 |
| Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord Stimulation Implantation of PNS electrodes during surgery, mapping to select sites with the best effect and daily modulation., SCS electrode implantation at surgery, mapping to select sites with the best effect and pain modulation, Change according to the scale of the PainDetect questionnaire - Phantom Limb Pain, Phantom Pain | Not applicable | Unknown | Artur Biktimirov | 10 | 2022-11-17 | 2023-04-11 |
| Protocole Access-Socket Access Socket, Rigid socket - Lower Limb Amputation | Not applicable | Completed | Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est | 17 | 2022-02-14 | 2024-02-07 |
| Evaluating Mobility Interventions in the Real World Lower limb prostheses, Orthoses for Drop-foot - Lower Limb Amputation, Drop Foot | Not applicable | Completed | University of Wisconsin, Madison | 20 | 2021-09-03 | 2025-12-19 |
| Transcutaneous Electrical Stimulation in Lower Limb Amputees Transcutaneous Electrical Nerve Stimulation - Lower Limb Amputation | Not applicable | Completed | Fondazione Don Carlo Gnocchi ETS | 13 | 2021-03-14 | 2023-12-13 |
| Comparative Effectiveness of Socket Casting Methods: Improving Form and Fit Symphonie Aqua SystemTM, Hand Casting - Lower Limb Amputation | Not applicable | Completed | Northwestern University | 80 | 2020-09-01 | 2024-09-19 |
| Phantom Exercise for Lower Limb Amputees phantom limb exercise, conventional treatment - Lower Limb Amputation | Not applicable | Completed | Riphah International University | 24 | 2020-07-01 | 2021-03-30 |
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Phantom Limb (3) · Amputation, Traumatic (1) · Bursitis (1) · Chronic Pain (1) · Fractures, Bone (1) · Mobility Limitation (1) · Neuralgia (1) · Pain (1) · Peroneal Neuropathies (1) · Pneumonia (1) · Psychological Well-Being (1) · Stroke (1) · Tendinopathy (1)
Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Neurologic Manifestations (4) · Neurobehavioral Manifestations (3) · Pain (3) · Pain, Postoperative (3) · Pathologic Processes (3) · Perceptual Disorders (3) · Postoperative Complications (3) · Neuromuscular Diseases (2) · Peripheral Nervous System Diseases (2) · Wounds and Injuries (2) · Behavior (1) · Brain Diseases (1)
Control Groups (2) · Artificial Limbs (1) · Bupivacaine (1) · Dexmedetomidine (1) · Gait Analysis (1) · Orthotic Devices (1) · Oxycodone (1) · Sodium Chloride (1) · Surveys and Questionnaires (1) · Telerehabilitation (1) · Transcutaneous Electric Nerve Stimulation (1) · Walking (1)
Ohio Willow Wood (2) · Queen Margaret University (2) · Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est (2) · University of British Columbia (2) · Al-Azhar University - Gaza (1) · Artur Biktimirov (1) · Centre Hospitalier Universitaire Dijon (1) · Fondazione Don Carlo Gnocchi ETS (1) · Indiana University (1) · Istanbul Rumeli University (1) · Istituti Clinici Scientifici Maugeri SpA (1) · Kafrelsheikh University (1) · Kharkiv National Medical University (1) · National University of Singapore (1) · Northwestern University (1)
United States (6) · United Kingdom (4) · France (3) · Italy (3) · Turkey (Türkiye) (3) · Canada (2) · Egypt (2) · Mexico (1) · Pakistan (1) · Palestinian Territories (1) · Russia (1) · Singapore (1) · Slovenia (1) · Ukraine (1)
Gayle Gordillo, MD (2) · Judy Scopes, MPhil (2) · Marietta van der Linden, MSc, PhD (2) · Amelie A Touillet (1) · Antonia Dr Pierobon (1) · Arshad Nawaz Malik, PhD (1) · Chandan Sen, PhD (1) · Cleveland T Barnett, Ph.D (1) · Helena Burger, MD, PhD (1) · Isabelle Loiret, PhD (1) · Jodi A Brangaccio, PT (1) · Mauro S Barone (1) · Miho Asano, PhD (1)
PMID 25533902, PMID 28355039, PMID 34706654, PMID 34841917, PMID 37276273, PMID 41270063
I21RX004410 (1)