37 completed, 37 unknown, 9 recruiting, 9 terminated. 104 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 104 | Completed 37, Unknown 37, Recruiting 9, Terminated 9, Active not recruiting 5, Not yet recruiting 3, Withdrawn 3, Enrolling by invitation 1 |
Follow Liver Cirrhosis: new trials by email Literature Review of Liver Cirrhosis trials Research Report on Liver Cirrhosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis Daridorexant, Placebo - Liver Cirrhosis, Sleep Disturbance | Phase 4 | Not yet recruiting | Wang Fengmei | 180 | 2026-09-01 | 2026-10-16 |
| Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study) early time restricted Mediterranean diet, Mysimba - Diabetes Mellitus, Type 2, Liver Fibrosis | Phase 4 | Enrolling by invitation | Carmen Dietvorst | 70 | 2025-04-14 | 2026-04-21 |
| Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM Henagliflozin 10 mg daily, Metformin 1700 mg daily, Placebo of Henagliflozin - Metabolic Dysfunction-associated Steatotic Liver Disease, Type 2 Diabetes Mellitus | Phase 4 | Not yet recruiting | Xiqiao Zhou | 190 | 2024-12-31 | 2025-01-07 |
| Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients Tranexamic Acid and vitamin K, Placebo - Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding | Phase 4 | Recruiting | Tanta University | 194 | 2024-12-02 | 2025-03-18 |
| A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy. Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose - Overt Hepatic Encephalopathy | Phase 4 | Completed | Qurratul Ain Jamil | 252 | 2024-12-02 | 2025-06-25 |
| Effect of a GnRH Analog on Hepatic Steatosis Goserelin Acetate 3.6 mg inj, implant - Metabolic Dysfunction-Associated Steatotic Liver Disease, Nonalcoholic Fatty Liver | Phase 4 | Active not recruiting | Aristotle University Of Thessaloniki | 62 | 2024-11-26 | 2026-07-23 |
| Fibrosis Lessens After Metabolic Surgery Metabolic surgery, Incretin-Based Therapy - Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease | Phase 4 | Recruiting | The Cleveland Clinic | 120 | 2024-07-11 | 2026-07-31 |
| Dose Optimization of Sitagliptin and Duloxetine in Diabetic Cirrhosis Sitagliptin (Januvia), Sitagliptin (JANUVIA®), Duloxetine (60 mg) once daily - Liver Cirrhosis With Diabetes | Phase 4 | Completed | Kafrelsheikh University | 64 | 2024-07-01 | 2026-02-27 |
| Clinical Study on the Treatment of Elevated Total Bilirubin in Primary Biliary Cholangitis With Baobao Dan Capsule Babaodan Capsule - Primary Biliary Cholangitis | Phase 4 | Unknown | Mei Han | 60 | 2024-04-25 | 2024-04-17 |
| Clinical Application of Simcyp-Guided Warfarin Initiation Doses in Cirrhotic Patients With Portal Vein Thrombosis Warfarin 3 mg, Warfarin 2 mg - Liver Cirrhosis, Portal Vein Thrombosis | Phase 4 | Completed | Kafrelsheikh University | 21 | 2024-03-15 | 2026-05-06 |
| Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver Cirrhosis Simvastatin 15 mg, Simvastatin 5 mg - Liver Cirrhosis, Portal Hypertension Related to Cirrhosis | Phase 4 | Completed | Kafrelsheikh University | 22 | 2024-03-15 | 2026-03-11 |
| Clinical Application of Simcyp-Guided Doses of Antihypertensive Drugs in Cirrhotic Patients Nebivolol 5 mg, Carvedilol 12.5 mg, Nebivolol 2.5 mg - Liver Cirrhosis, Arterial Hypertension | Phase 4 | Completed | Kafrelsheikh University | 40 | 2024-03-01 | 2026-02-09 |
| Real-world Elecsys® GAAD Implementation and Validation to Improve Surveillance and Early Detection of HCC Elecsys® GAAD - Liver Cirrhosis, Hepatocellular Carcinoma | Phase 4 | Completed | Manchester University NHS Foundation Trust | 657 | 2024-01-08 | 2026-10-09 |
| National Liver Cancer Screening Trial GALAD, Liver Ultrasound with or without AFP - Carcinoma, Hepatocellular, Liver Cancer | Phase 4 | Recruiting | University of Texas Southwestern Medical Center | 5500 | 2023-12-26 | 2026-09-25 |
| Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding Proton Pump Inhibitors, No Proton Pump Inhibitors - Upper Gastrointestinal Hemorrhage | Phase 4 | Not yet recruiting | West China Hospital | 672 | 2023-10-01 | 2023-09-28 |
| Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate - Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3 | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 360 | 2023-10-01 | 2023-07-13 |
| Effect of Erugliflozin On Liver Fat, Liver Fibrosis and Glycemic Control in Type II DM Patients With NASH/NAFLD Ertugliflozin 5 mg, 15mg - Liver Fat, Liver Fibrosis | Phase 4 | Recruiting | Getz Pharma | 164 | 2023-03-01 | 2025-03-21 |
| Coagulation in Cirrhosis Platelet Concentrate, Prothrombin Complex Concentrate, Restricitve Use - Liver Cirrhosis | Phase 4 | Recruiting | Medical University of Vienna | 400 | 2023-01-19 | 2025-01-14 |
| Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease Denosumab, Alendronate Sodium - Nonalcoholic Fatty Liver, Osteoporosis, Postmenopausal | Phase 4 | Completed | Aristotle University Of Thessaloniki | 72 | 2022-12-23 | 2026-07-23 |
| Efficacy and Safety of Intravenous Vitamin K1 in Management of Acute Variceal Bleeding Vitamin K1 - Variceal Bleeding | Phase 4 | Completed | Zagazig University | 66 | 2022-10-03 | 2025-02-21 |
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Liver Cirrhosis, Biliary (14) · Fibrosis (13) · Hypertension, Portal (12) · Hepatic Encephalopathy (7) · Hepatitis B, Chronic (7) · Hepatitis B (6) · Ascites (4) · Carcinoma, Hepatocellular (4) · Diabetes Mellitus, Type 2 (4) · Esophageal and Gastric Varices (4) · Gastrointestinal Hemorrhage (4) · Hepatitis C (4) · Non-alcoholic Fatty Liver Disease (4) · Diabetes Mellitus (3)
Digestive System Diseases (104) · Pathological Conditions, Signs and Symptoms (104) · Pathologic Processes (103) · Liver Diseases (101) · Fibrosis (91) · Infections (24) · Hepatitis (21) · Blood-Borne Infections (20) · Communicable Diseases (20) · Virus Diseases (20) · Hepatitis, Viral, Human (18) · Nutritional and Metabolic Diseases (16) · Metabolic Diseases (15) · Bile Duct Diseases (14)
Rifaximin (7) · entecavir (6) · Carvedilol (4) · Lactulose (4) · Propranolol (4) · Warfarin (4) · Mycophenolic Acid (3) · Nadroparin (3) · Proton Pump Inhibitors (3) · Simvastatin (3) · Ursodeoxycholic Acid (3) · Albumins (2) · Ceftriaxone (2) · Cyclosporine (2) · Esomeprazole (2)
West China Hospital (5) · Beijing Friendship Hospital (4) · Kafrelsheikh University (4) · Shanghai Zhongshan Hospital (4) · Taipei Veterans General Hospital, Taiwan (3) · Aristotle University Of Thessaloniki (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Hospital Clinic of Barcelona (2) · Hvidovre University Hospital (2) · Intercept Pharmaceuticals (2) · King's College Hospital NHS Trust (2) · Weill Medical College of Cornell University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Asian Institute of Gastroenterology, India (1) · Azienda Ospedaliera San Camillo Forlanini (1)
China (27) · United States (17) · Egypt (8) · Spain (8) · Germany (6) · Italy (6) · Denmark (5) · South Korea (5) · United Kingdom (5) · Belgium (4) · India (4) · Mexico (4) · Brazil (3) · Canada (3) · Israel (3)
Shiyao Chen, Professor (4) · Hong You, Doctor (3) · Ming-Chih Hou, MD (3) · Candido Villanueva, MD (2) · Dimitrios G Goulis, MD, PhD (2) · Li Yang, MD (2) · Noha Mahmoud El-khodary, PhD (2) · Stergios A Polyzos, MD, PhD (2) · Adriano M Pellicelli, MD (1) · Ahmad A Khairy, MD (1) · Ahmed A Ali, PhD (1) · Ahmed A. Gomaa, MD (1) · Ali Aminian, MD (1) · Amit Singal, MD, MS (1) · Angelos Daniilidis, MD, PhD (1)
PMID 37467180, PMID 19208350, PMID 33460002, PMID 34843068, PMID 39373164, PMID 11588440, PMID 11876689, PMID 12500513, PMID 14988829, PMID 16134766, PMID 16306522, PMID 17327353, PMID 17484872, PMID 19344721, PMID 19628656, PMID 20109575, PMID 23840211, PMID 24151551, PMID 24840288, PMID 24997638, PMID 25381721, PMID 25546176, PMID 26191473, PMID 26744140, PMID 26890629, PMID 27121784, PMID 27775818, PMID 27782373, PMID 28404091, PMID 28404092, PMID 28671712, PMID 29289383, PMID 29364196, PMID 29638020, PMID 29756595, PMID 29861076, PMID 30240471, PMID 31011303, PMID 31592079, PMID 32437567, PMID 32568867, PMID 32617767, PMID 33372103, PMID 33409402, PMID 33654016, PMID 33915943, PMID 34571050, PMID 34697111, PMID 35068788, PMID 36594820
2008 (1), 2018 (1), 2019 (1), 2023 (1), U24CA086368 (1)