Cholestasis, Intrahepatic: Clinical Trials

116 completed, 39 recruiting, 33 unknown, 23 terminated. 73 Phase 2, 52 Phase 3, 26 Phase 1, 23 Not applicable, 17 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	73	Completed 41, Terminated 12, Not yet recruiting 5, Unknown 5, Withdrawn 4, Active not recruiting 3, Recruiting 2, Enrolling by invitation 1
Phase 3	52	Completed 21, Recruiting 11, Unknown 8, Active not recruiting 7, Terminated 2, Enrolling by invitation 1, Not yet recruiting 1, Withdrawn 1
Phase 1	26	Completed 19, Unknown 3, Withdrawn 2, Not yet recruiting 1, Recruiting 1
Not applicable	23	Completed 12, Terminated 4, Unknown 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Withdrawn 1
Phase 4	17	Unknown 7, Completed 5, Terminated 3, Recruiting 2
Early Phase 1	4	Completed 2, Active not recruiting 1, Unknown 1

Follow Cholestasis, Intrahepatic: new trials by email Literature Review of Cholestasis, Intrahepatic trials Research Report on Cholestasis, Intrahepatic

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease	Phase 2	Not yet recruiting	Mayo Clinic	15	2026-11-01	2026-09-28
J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus	Phase 3	Not yet recruiting	GlaxoSmithKline	40	2026-10-09	2026-10-06
Study of Seladelpar and Cilofexor in Participants With Primary Biliary Cholangitis Seladelpar, PTM Seladelpar, Cilofexor Dose B - Primary Biliary Cholangitis	Phase 2	Not yet recruiting	Gilead Sciences	132	2026-10-01	2026-09-25
Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary Cholangitis Standard background therapy, Placebo, hUC-MSC Dose Level 1 - Primary Biliary Cholangitis	Phase 1 / Phase 2	Not yet recruiting	Beijing 302 Hospital	68	2026-08-31	2026-08-31
Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA Therapy Saroglitazar Magnesium 1 mg, Placebo - Primary Biliary Cholangitis	Phase 3	Recruiting	Zydus Therapeutics Inc.	90	2026-08-11	2026-09-15
Determine the Prevalence of Exocrine Pancreatic Insufficiency (EPI) in Pediatric and Adult Participants With Alagille Syndrome After Liver Transplantation Fecal Fat - Exocrine Pancreatic Insuficiency		Recruiting	Digestive Care, Inc.	30	2026-08-03	2026-10-13
Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease Progression PBC		Not yet recruiting	Beijing Municipal Administration of Hospitals	300	2026-08-01	2026-08-04
Elafibranor Pregnancy Surveillance Program: A Study to Evaluate the Safety of Elafibranor During Pregnancy Elafibranor - Pregnancy Related		Recruiting	Ipsen	3	2026-07-29	2026-10-06
A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment Alagille Syndrome		Recruiting	Ipsen	30	2026-07-10	2026-10-01
LEOPARD Prospective Validation Cohort 1 Standardized assessments, guided tumor biopsy and biobanking, Standardized assessments and biobanking - Decompensated Liver Cirrhosis, Primary Biliary Cholangitis		Recruiting	Assistance Publique - Hôpitaux de Paris	630	2026-07-07	2026-07-29
Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC) Primary Biliary Cholangitis (PBC)		Enrolling by invitation	Stanford University	30	2026-07-01	2026-06-11
The Value of Spleen Stiffness Measurement in Patients With PBC Spleen stiffness measurement - Primary Biliary Cholangitis, Spleen Stiffness	Not applicable	Not yet recruiting	Universitair Ziekenhuis Brussel	125	2026-07-01	2026-05-01
TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis Nalmefene, Placebo - Pruritus, Primary Biliary Cholangitis	Phase 2	Not yet recruiting	Tharimmune Inc	40	2026-06-01	2025-09-09
The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching Upadacitinib 15 MG - Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC)	Phase 2	Not yet recruiting	RenJi Hospital	44	2026-06-01	2026-07-01
Patients With Primary Biliary Cholangitis(PBC) Primary Biliary Cholangitis, Liver Fibrosis		Active not recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	30	2026-05-18	2026-06-05
Patients With Primary Biliary Cholangitis Reflex AMA and ANA testing - Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer	Not applicable	Active not recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2000	2026-04-23	2026-05-07
Pediatric Evaluation and Registry for Liver Cholestasis in Canada PFIC - Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome (ALGS)		Recruiting	Children's Hospital of Eastern Ontario	220	2026-04-21	2026-10-08
Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia Questionnaires - Dental Diseases		Recruiting	University Hospital, Toulouse	120	2026-04-07	2026-05-12
Long-Term Study to Evaluate the Safety and Efficacy in Participants With Primary Biliary Cholangitis of Saroglitazar Magnesium-V on Clinical Outcomes Saroglitazar magnesium 1 mg, Placebo - Primary Biliary Cholangitis	Phase 3	Recruiting	Zydus Therapeutics Inc.	386	2026-03-24	2026-08-04
Austrian PBC Registry Primary Biliary Cholangitis, Liver Cirrhosis		Recruiting	Medical University of Vienna	500	2026-03-18	2026-05-20

Showing 20 of 252. Sign in to see all of them.

Narrower conditions

Liver Cirrhosis, Biliary (212)  ·  Alagille Syndrome (31)  ·  Cholestasis (20)  ·  Cholangitis, Sclerosing (19)  ·  Pruritus (19)  ·  Hepatitis, Autoimmune (14)  ·  Cholestasis, progressive familial intrahepatic 1 (13)  ·  Fibrosis (13)  ·  Liver Diseases (12)  ·  Liver Cirrhosis (10)  ·  Cholangitis (9)  ·  Fatigue (9)  ·  Biliary Atresia (8)  ·  Bile Duct Diseases (6)

Broader conditions

Biliary Tract Diseases (247)  ·  Bile Duct Diseases (246)  ·  Digestive System Diseases (246)  ·  Liver Diseases (240)  ·  Cholestasis (232)  ·  Pathological Conditions, Signs and Symptoms (221)  ·  Pathologic Processes (217)  ·  Liver Cirrhosis (203)  ·  Fibrosis (200)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (42)  ·  Congenital Abnormalities (36)  ·  Cardiovascular Diseases (35)  ·  Genetic Diseases, Inborn (33)  ·  Abnormalities, Multiple (31)

Interventions

Ursodeoxycholic Acid (27)  ·  obeticholic acid (13)  ·  Fenofibrate (12)  ·  maralixibat (9)  ·  seladelpar (8)  ·  2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (6)  ·  saroglitazar (6)  ·  Bezafibrate (5)  ·  Blood Specimen Collection (4)  ·  Surveys and Questionnaires (4)  ·  (2-methyl-4-(5-methyl-2-(4-trifluoromethyl-phenyl)-2H-(1,2,3)triazol-4-ylmethylsulfanyl)phenoxy)acetic acid (3)  ·  3-((((3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl)methyl)amino)pentanedioic acid (3)  ·  Budesonide (3)  ·  Methotrexate (3)  ·  S-Adenosylmethionine (3)

Sponsors

Mirum Pharmaceuticals, Inc. (14)  ·  Xijing Hospital of Digestive Diseases (12)  ·  Intercept Pharmaceuticals (11)  ·  Gilead Sciences (10)  ·  Ipsen (9)  ·  GlaxoSmithKline (8)  ·  Mayo Clinic (7)  ·  University of Alberta (7)  ·  University of Aarhus (6)  ·  Zydus Therapeutics Inc. (6)  ·  Cascade Pharmaceuticals, Inc (5)  ·  West China Hospital (5)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4)  ·  Albireo (3)  ·  Assistance Publique - Hôpitaux de Paris (3)

Countries

United States (100)  ·  China (53)  ·  United Kingdom (48)  ·  Canada (46)  ·  Germany (35)  ·  Spain (35)  ·  France (34)  ·  Italy (30)  ·  Belgium (24)  ·  Australia (20)  ·  Poland (20)  ·  Netherlands (18)  ·  Austria (15)  ·  Argentina (14)  ·  Israel (14)

Top investigators

Li Yang, MD (5)  ·  Christopher L Bowlus, MD (3)  ·  Christian Weyer, MD (2)  ·  Cynthia Levy, MD (2)  ·  Deven Parmar (2)  ·  Ed Doo, MD (2)  ·  Francesca Romana Ponziani (2)  ·  John Magee, MD (2)  ·  Keith D Lindor, MD (2)

Results publications

PMID 25543678, PMID 42002216, PMID 28249726, PMID 37953500, PMID 38780109, PMID 40439725, PMID 10022591, PMID 10051462, PMID 10102814, PMID 10343514, PMID 10347106, PMID 10655252, PMID 11906641, PMID 12183720, PMID 12360466, PMID 15017671, PMID 15128074, PMID 15269615, PMID 15468571, PMID 16299032, PMID 16530513, PMID 16848809, PMID 16863557, PMID 17399846, PMID 17680647, PMID 18041714, PMID 18310188, PMID 18752324, PMID 18778710, PMID 19458352, PMID 19491853, PMID 19554543, PMID 19687773, PMID 19782361, PMID 20393276, PMID 20578265, PMID 21083674, PMID 21810549, PMID 22245904, PMID 22259000, PMID 22271046, PMID 22454486, PMID 22683686, PMID 22911624, PMID 23141888, PMID 23490343, PMID 23978872, PMID 24317935, PMID 24440215, PMID 24561556

NIH funding

2016 (5), 2014 (2), 2015 (2), 2019 (2), 2023 (2), U01DK062436 (2), U01DK062445 (2), U01DK062452 (2), U01DK062453 (2), U01DK062456 (2), U01DK062466 (2), U01DK062470 (2), U01DK062481 (2), U01DK062497 (2), U01DK062500 (2)