21 completed, 3 terminated, 2 recruiting, 2 unknown. 31 Phase 2, 8 Phase 1, 1 Phase 3.
Follow Lip Diseases: new trials by email Literature Review of Lip Diseases trials Research Report on Lip Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-11-30 | 2026-11-03 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Evaluation of a Novel Nasal Conformer in Pediatric Patients use of an anatomically designed nasal conformer - Cleft Lip, Nasal Surgical Procedures | Phase 2 | Enrolling by invitation | East Tennessee Children's Hospital | 20 | 2025-06-01 | 2026-09-16 |
| Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Cleft Palate. implantation with an autologous human palatal mucosa substitute made of nanostructured fibrin-agarose generated by tissue engineering (BIOCLEFT). - Cleft Lip and Palate | Phase 1 / Phase 2 | Recruiting | Elisa María Cubiles Montero de Espinosa | 15 | 2024-04-17 | 2024-05-10 |
| Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection HDIT101 (blinded therapy), Placebo (blinded therapy), Photo documentation of orolabial herpes lesions - Herpes Labialis | Phase 2 | Terminated | Heidelberg ImmunoTherapeutics GmbH | 761 | 2020-10-08 | 2023-09-25 |
| An Open Label Study to Evaluate the Safety and Efficacy of BOR15001L7 for the Treatment of Cold Sores in Patients With Recurrent Herpes Labialis BOR15001L7, Docosanol Cream 10% - Recurrent Herpes Labialis | Phase 2 | Unknown | Laboratoire Boreaderme Inc. | 164 | 2020-09-01 | 2020-09-07 |
| Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene A166 - HER2-positive Breast Cancer, HER2 Gene Mutation | Phase 1 / Phase 2 | Completed | Klus Pharma Inc. | 49 | 2018-07-16 | 2023-08-03 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis Squaric Acid Dibutyl Ester - Herpes Labialis, HSV | Phase 2 | Terminated | Squarex, LLC | 40 | 2018-03-12 | 2021-08-06 |
| Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma Durvalumab, Carboplatin, Nab-paclitaxel - Carcinoma, Squamous Cell, Oral Cancer | Phase 2 | Active not recruiting | UNC Lineberger Comprehensive Cancer Center | 39 | 2017-12-19 | 2026-02-23 |
| Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma Cetuximab, Ficlatuzumab - Head and Neck Basaloid Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 2 | Completed | University of Arizona | 78 | 2017-12-05 | 2024-09-04 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores Merlin, Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 451 | 2017-07-05 | 2018-09-12 |
| Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis SADBE, Placebo - Herpes Labialis, Cold Sore | Phase 1 / Phase 2 | Completed | Squarex, LLC | 139 | 2016-12-01 | 2021-11-02 |
| Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Pritelivir 5% w/w ointment, Pritelivir ointment matching placebo, Zovirax® cream - Herpes Labialis | Phase 2 | Completed | AiCuris Anti-infective Cures AG | 362 | 2016-11-29 | 2021-07-13 |
| Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Botulinum Toxin Type A, Normal Saline Injection - Cleft Lip, Scarring | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center, Houston | 30 | 2015-12-01 | 2021-11-03 |
| Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores ZEP-3 ointment 1.0%, Acyclovir cream 5% - Herpes Labialis | Phase 2 | Completed | Shulov Innovate for Science Ltd. 2012 | 210 | 2015-09-01 | 2019-05-30 |
| Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone) Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold) - Clift Lip, Cleft Palate | Phase 1 / Phase 2 | Completed | Hospital Sirio-Libanes | 20 | 2015-03-01 | 2026-07-29 |
| A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex Labialis VDO gel, placebo - Herpes Labialis | Phase 2 | Completed | Yung Shin Pharm. Ind. Co., Ltd. | 40 | 2014-07-01 | 2016-04-15 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores ethanol/glycolic acid solution, Placebo/Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 469 | 2013-11-01 | 2015-07-16 |
| Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores Matching Placebo, BTL-TML-HSV - Oral Herpes Simplex | Phase 2 | Completed | Beech Tree Labs, Inc. | 303 | 2013-07-01 | 2016-04-28 |
Showing 20 of 31. Sign in to see all of them.
Herpes Labialis (20) · Cleft Lip (7) · Herpes Simplex (5) · Lip Neoplasms (4) · Mouth Neoplasms (4) · Carcinoma, Squamous Cell (3) · Cleft Palate (3) · Head and Neck Neoplasms (3) · Laryngeal Neoplasms (3) · Oropharyngeal Neoplasms (3) · Squamous Cell Carcinoma of Head and Neck (3) · Stomatitis, Herpetic (2) · Tongue Neoplasms (2) · Alveolar Bone Loss (1) · Bile Duct Neoplasms (1)
Mouth Diseases (31) · Stomatognathic Diseases (31) · Skin Diseases (21) · Skin and Connective Tissue Diseases (21) · DNA Virus Infections (20) · Infections (20) · Skin Diseases, Viral (20) · Virus Diseases (20) · Herpesviridae Infections (19) · Skin Diseases, Infectious (19) · Herpes Simplex (15) · Congenital Abnormalities (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Mouth Abnormalities (7)
Botulinum Toxins, Type A (2) · Ethanol (2) · Neurofibromin 2 (2) · Saline Solution (2) · squaric acid dibutyl ester (2) · 130-nm albumin-bound paclitaxel (1) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (1) · Acyclovir (1) · Albumin-Bound Paclitaxel (1) · Carboplatin (1) · Cetuximab (1) · Cisplatin (1) · Drug Implants (1) · Famciclovir (1) · Glutamine (1)
Beech Tree Labs, Inc. (2) · Squarex, LLC (2) · Topical Remedy (2) · Transport Pharmaceuticals (2) · AiCuris Anti-infective Cures AG (1) · Children's National Research Institute (1) · China Academy of Chinese Medical Sciences (1) · East Tennessee Children's Hospital (1) · Elisa María Cubiles Montero de Espinosa (1) · Heidelberg ImmunoTherapeutics GmbH (1) · Hospital Sirio-Libanes (1) · Klus Pharma Inc. (1) · Laboratoire Boreaderme Inc. (1) · Medivir (1) · NanoBio Corporation (1)
United States (21) · Brazil (2) · China (1) · Germany (1) · Hong Kong (1) · Israel (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Alicia Bucko, DO (1) · Brian Bock, DO (1) · Christopher Hull, MD (1) · Christopher M Hull, MD (1) · Cynthia B Strout, MD (1) · Daniel H Brune, MD (1) · Daniel Stewart, MD (1) · David Fried, MD (1) · Dennis Riff, MD (1) · Douglass Forsha, MD (1) · Edward Pornoy, MD (1) · Elias Kolettis, MD (1) · Eric M Morrel, PhD (1) · Eugene Monroe, MD (1)
PMID 35142535, PMID 19143902, PMID 21178655, PMID 36977289, PMID 39638596
P30CA023074 (1), R01DE010437 (1)