42 completed, 5 unknown, 4 terminated, 1 recruiting. 20 Phase 2, 14 Phase 3, 10 Not applicable, 7 Phase 1, 3 Phase 4.
Follow Herpes Labialis: new trials by email Literature Review of Herpes Labialis trials Research Report on Herpes Labialis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Investigation Into the Efficacy of Herpecin L at Reducing the Frequency and Severity of Cold Sores Herpecin L - Cold Sores | Not applicable | Completed | Focus Consumer Healthcare | 80 | 2023-01-04 | 2023-04-03 |
| Post-marketing Study for the Evaluation of Profilm Cold Sores Profilm Cold Sores - Cold Sores | Not applicable | Completed | i+Med S.Coop. | 35 | 2022-12-13 | 2025-04-01 |
| Hand Sanitizer Use for Herpes Simplex Virus-1 Purell Hand Sanitizer, Medical Grade Mineral Oil - Virus, HSV-1 | Early Phase 1 | Unknown | Leciel Bono | 20 | 2022-04-08 | 2023-11-18 |
| A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works Normally Acyclovir 50mg buccal/topical tablet, BAYM008894/UI1614773, Placebo - Recurrent Herpes Labialis | Phase 3 | Completed | Bayer | 2020 | 2021-11-23 | 2025-09-02 |
| Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection HDIT101 (blinded therapy), Placebo (blinded therapy), Photo documentation of orolabial herpes lesions - Herpes Labialis | Phase 2 | Terminated | Heidelberg ImmunoTherapeutics GmbH | 761 | 2020-10-08 | 2023-09-25 |
| An Open Label Study to Evaluate the Safety and Efficacy of BOR15001L7 for the Treatment of Cold Sores in Patients With Recurrent Herpes Labialis BOR15001L7, Docosanol Cream 10% - Recurrent Herpes Labialis | Phase 2 | Unknown | Laboratoire Boreaderme Inc. | 164 | 2020-09-01 | 2020-09-07 |
| Treatment of Herpes Labialis by Photodynamic Therapy photodynamic therapy herpes labialis - Photodynamic Therapy, Herpes Simplex, Labial | Not applicable | Completed | University of Nove de Julho | 24 | 2020-01-01 | 2023-11-21 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis Squaric Acid Dibutyl Ester - Herpes Labialis, HSV | Phase 2 | Terminated | Squarex, LLC | 40 | 2018-03-12 | 2021-08-06 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores Merlin, Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 451 | 2017-07-05 | 2018-09-12 |
| Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Squaric Acid Dibutyl Ester - HSV, Herpes Labialis | Phase 1 | Completed | Squarex, LLC | 36 | 2017-03-02 | 2021-11-03 |
| Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis SADBE, Placebo - Herpes Labialis, Cold Sore | Phase 1 / Phase 2 | Completed | Squarex, LLC | 139 | 2016-12-01 | 2021-11-02 |
| Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Pritelivir 5% w/w ointment, Pritelivir ointment matching placebo, Zovirax® cream - Herpes Labialis | Phase 2 | Completed | AiCuris Anti-infective Cures AG | 362 | 2016-11-29 | 2021-07-13 |
| Study of a New Topical Natural Health Product for the Treatment of Herpes Labialis BOR15001L7, Placebo - Herpes Labialis | Not applicable | Unknown | Laboratoire Boreaderme Inc. | 40 | 2016-01-01 | 2017-03-09 |
| Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores ZEP-3 ointment 1.0%, Acyclovir cream 5% - Herpes Labialis | Phase 2 | Completed | Shulov Innovate for Science Ltd. 2012 | 210 | 2015-09-01 | 2019-05-30 |
| Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis Acyclovir 5 percent (Perrigo), Acyclovir 5 percent (Reference), Placebo cream - Herpes Labialis | Phase 3 | Completed | Padagis LLC | 4076 | 2014-10-06 | 2021-10-22 |
| A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex Labialis VDO gel, placebo - Herpes Labialis | Phase 2 | Completed | Yung Shin Pharm. Ind. Co., Ltd. | 40 | 2014-07-01 | 2016-04-15 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores ethanol/glycolic acid solution, Placebo/Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 469 | 2013-11-01 | 2015-07-16 |
| Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis Squaric Acid solution, Placebo solution - Herpes Labialis | Phase 1 | Completed | Massachusetts General Hospital | 54 | 2013-10-01 | 2017-10-02 |
| Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores Matching Placebo, BTL-TML-HSV - Oral Herpes Simplex | Phase 2 | Completed | Beech Tree Labs, Inc. | 303 | 2013-07-01 | 2016-04-28 |
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DNA Virus Infections (52) · Infections (52) · Lip Diseases (52) · Mouth Diseases (52) · Skin Diseases (52) · Skin Diseases, Viral (52) · Skin and Connective Tissue Diseases (52) · Stomatognathic Diseases (52) · Herpesviridae Infections (51) · Skin Diseases, Infectious (51) · Virus Diseases (50) · Herpes Simplex (41) · Stomatitis (4) · Communicable Diseases (1) · Coronaviridae Infections (1)
Acyclovir (6) · ME 609 (4) · squaric acid dibutyl ester (4) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (3) · Famciclovir (3) · Ethanol (2) · Neurofibromin 2 (2) · Prebiotics (2) · Probiotics (2) · penciclovir (2) · Allantoin (1) · Botulinum Toxins, Type A (1) · Glutamine (1) · Glycine (1) · Hand Sanitizers (1)
Medivir (4) · NanoBio Corporation (4) · GlaxoSmithKline (3) · Squarex, LLC (3) · Beech Tree Labs, Inc. (2) · Laboratoire Boreaderme Inc. (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Novartis (2) · Novartis Pharmaceuticals (2) · Sprim Advanced Life Sciences (2) · Topical Remedy (2) · Transport Pharmaceuticals (2) · AiCuris Anti-infective Cures AG (1) · Bayer (1) · China Academy of Chinese Medical Sciences (1)
United States (30) · Germany (4) · United Kingdom (4) · Brazil (2) · Australia (1) · Canada (1) · China (1) · Czechia (1) · France (1) · Israel (1) · Japan (1) · Panama (1) · Poland (1) · Spain (1) · Switzerland (1)
Christopher M Hull, MD (2) · Alexandra B Kimball, MD (1) · Alicia Bucko, DO (1) · Anders Strand, MD PhD (1) · Brian Bock, DO (1) · Christopher Hull, MD (1) · Clare Kendall (1) · Cynthia B Strout, MD (1) · Daniel H Brune, MD (1) · Daniel Stewart, MD (1) · David Fried, MD (1)
PMID 35142535, PMID 19143902, PMID 19273678, PMID 19382840, PMID 20851499, PMID 21178655, PMID 25770054, PMID 29868164, PMID 30756512, PMID 32195950, PMID 33913104, PMID 36482505, PMID 40485092