10 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 14 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 10, Unknown 2, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 8 | Completed 5, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Lip Diseases: new trials by email Literature Review of Lip Diseases trials Research Report on Lip Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-11-30 | 2026-11-03 |
| Evaluation of Nasal Elevator Versus Grayson's Nasal Stent with D-NAM Appliance on Nasolabial Esthetics in Bilateral Cleft Lip and Palate Infants Nasal elevator with digital nasoalveolar molding in bilateral cleft lip and palate infants, Nasal stent with digital nasoalveolar molding in bilateral cleft lip and palate infants - Cleft Lip and Cleft Palate | Phase 1 | Unknown | Cairo University | 20 | 2024-11-01 | 2024-10-17 |
| Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Cleft Palate. implantation with an autologous human palatal mucosa substitute made of nanostructured fibrin-agarose generated by tissue engineering (BIOCLEFT). - Cleft Lip and Palate | Phase 1 / Phase 2 | Recruiting | Elisa María Cubiles Montero de Espinosa | 15 | 2024-04-17 | 2024-05-10 |
| Comparison Between Low Level Laser Therapy and Active Oxygen Releasing Gel on Wound Healing Cleft Lip Patients biolase laser, blue m gel - Cleft Lip | Phase 1 | Completed | Faculty of Dental Medicine for Girls | 15 | 2022-08-20 | 2025-01-09 |
| Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene A166 - HER2-positive Breast Cancer, HER2 Gene Mutation | Phase 1 / Phase 2 | Completed | Klus Pharma Inc. | 49 | 2018-07-16 | 2023-08-03 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Squaric Acid Dibutyl Ester - HSV, Herpes Labialis | Phase 1 | Completed | Squarex, LLC | 36 | 2017-03-02 | 2021-11-03 |
| Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis SADBE, Placebo - Herpes Labialis, Cold Sore | Phase 1 / Phase 2 | Completed | Squarex, LLC | 139 | 2016-12-01 | 2021-11-02 |
| Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Botulinum Toxin Type A, Normal Saline Injection - Cleft Lip, Scarring | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center, Houston | 30 | 2015-12-01 | 2021-11-03 |
| Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone) Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold) - Clift Lip, Cleft Palate | Phase 1 / Phase 2 | Completed | Hospital Sirio-Libanes | 20 | 2015-03-01 | 2026-07-29 |
| Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis Squaric Acid solution, Placebo solution - Herpes Labialis | Phase 1 | Completed | Massachusetts General Hospital | 54 | 2013-10-01 | 2017-10-02 |
| An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore Episode Acyclovir patch, Placebo patch - Herpes Labialis | Phase 1 | Completed | GlaxoSmithKline | 60 | 2012-07-01 | 2014-07-16 |
| Safety and Efficacy Study of a New Treatment for Recurrent Symptoms of Oral Herpes Virus Infection BTL TML HSV, Matching placebo - Oral Herpes Simplex | Phase 1 / Phase 2 | Completed | Beech Tree Labs, Inc. | 171 | 2011-01-01 | 2013-08-13 |
| Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy Volunteers New formulation, Current formulation - Herpes Labialis | Phase 1 | Completed | GlaxoSmithKline | 27 | 2008-04-10 | 2018-08-31 |
Herpes Labialis (7) · Cleft Lip (5) · Cleft Palate (3) · Cicatrix (2) · Head and Neck Neoplasms (2) · Laryngeal Neoplasms (2) · Lip Neoplasms (2) · Mouth Neoplasms (2) · Tongue Neoplasms (2) · Alveolar Bone Loss (1) · Bile Duct Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Mucoepidermoid (1) · Carcinoma, Renal Cell (1) · Carcinoma, Squamous Cell (1)
Mouth Diseases (14) · Stomatognathic Diseases (14) · Skin Diseases (8) · Skin and Connective Tissue Diseases (8) · DNA Virus Infections (7) · Herpesviridae Infections (7) · Infections (7) · Skin Diseases, Infectious (7) · Skin Diseases, Viral (7) · Virus Diseases (7) · Herpes Simplex (6) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Mouth Abnormalities (5)
squaric acid dibutyl ester (3) · Botulinum Toxins, Type A (1) · Drug Implants (1) · Saline Solution (1) · huanglian-jie-du decoction (1) · pembrolizumab (1)
GlaxoSmithKline (2) · Squarex, LLC (2) · Beech Tree Labs, Inc. (1) · Cairo University (1) · China Academy of Chinese Medical Sciences (1) · Elisa María Cubiles Montero de Espinosa (1) · Faculty of Dental Medicine for Girls (1) · Hospital Sirio-Libanes (1) · Klus Pharma Inc. (1) · Massachusetts General Hospital (1) · The University of Texas Health Science Center, Houston (1) · Washington University School of Medicine (1)
United States (7) · Brazil (1) · China (1) · Egypt (1) · Germany (1) · Japan (1) · Spain (1)
Alexandra B Kimball, MD (1) · Hugh McTavish, PhD, JD (1) · Jaecel O Shah, MD (1) · Jordi Rodon Ahnert, MD, PhD (1) · Mark Matson, MD (1) · Mohsena Ahmed (1) · Sana Karam, MD, PhD (1) · Sidharth Puram, MD, PhD (1) · Thomas D Horn, MD (1) · Zhong Wang (1)