9 completed, 2 terminated. 7 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Terminated 2 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC) Remetinostat - Squamous Cell Carcinoma | Phase 2 | Terminated | Kavita Sarin | 4 | 2019-12-12 | 2021-05-20 |
| A Study to Evaluate MIV-818 in Patients With Liver Cancer Manifestations MIV-818 (fostroxacitabine bralpamide) + pembrolizumab, MIV-818 (fostroxacitabine bralpamide) + lenvatinib - Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma | Phase 1 / Phase 2 | Completed | Medivir | 53 | 2018-09-05 | 2025-07-01 |
| Topical Remetinostat in Treating Patient With Cutaneous Basal Cell Cancer Remetinostat - Skin Basal Cell Carcinoma | Phase 2 | Completed | Kavita Sarin | 30 | 2018-07-07 | 2021-06-08 |
| A Bioavailability Study of MIV-711 Oral Formulations in Healthy Volunteers MIV-711 - Healthy | Phase 1 | Completed | Medivir | 18 | 2018-01-19 | 2018-02-23 |
| Dose-escalation Study of Birinapant and Pembrolizumab in Solid Tumors Birinapant, Pembrolizumab - Solid Tumors | Phase 1 / Phase 2 | Terminated | Medivir | 34 | 2017-08-04 | 2021-01-14 |
| A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients MIV-711 - Osteoarthritis, Knee | Phase 2 | Completed | Medivir | 50 | 2016-09-01 | 2019-03-18 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of MIV-711 in Osteoarthritis Patients MIV-711, Placebo - Osteoarthritis, Knee | Phase 2 | Completed | Medivir | 244 | 2016-01-28 | 2019-06-17 |
| Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised Patients ME-609, Acyclovir in ME-609 vehicle (5% acyclovir) - Herpes Labialis | Phase 3 | Completed | Medivir | 201 | 2006-12-01 | 2008-08-15 |
| Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents ME-609 - Herpes Labialis | Phase 3 | Completed | Medivir | 254 | 2006-10-01 | 2008-08-18 |
| Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis ME-609, acyclovir in ME-609 vehicle, Vehicle - Herpes Labialis | Phase 3 | Completed | Medivir | 1443 | 2006-07-01 | 2008-08-18 |
| Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes Labialis ME-609, Vehicle - Herpes Labialis | Phase 2 | Completed | Medivir | 417 | 1999-08-01 | 2008-08-15 |
Herpes Labialis (4) · Osteoarthritis, Knee (2) · Carcinoma, Basal Cell (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Squamous Cell (1) · Cholangiocarcinoma (1)
ME 609 (4) · MIV-711 (3) · Acyclovir (2) · pembrolizumab (2) · remetinostat (2) · birinapant (1) · lenvatinib (1)
United States (5) · Bulgaria (2) · Georgia (2) · Germany (2) · Moldova (2) · United Kingdom (2) · Belgium (1) · Romania (1) · South Korea (1) · Spain (1)
Philip Conaghan, Professor (2) · Allen Hunt (1) · Anders Strand, MD PhD (1) · Christopher M Hull, MD (1) · Kavita Sarin (1) · Kavita Y Sarin, MD, PhD (1) · Ruth Plummer, Professor (1) · Spotswood L Spruance, MD (1)