17 completed. 17 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 17 |
| Phase 2 | 6 | Completed 6 |
Follow Language Disorders: new trials by email Literature Review of Language Disorders trials Research Report on Language Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S QBS10072S - Astrocytoma, Brain Cancer | Phase 1 | Completed | Quadriga Biosciences, Inc. | 15 | 2020-07-20 | 2023-01-18 |
| Proof-of-concept Study of LUNA Intervention in Aphasia LUNA - Aphasia, Stroke | Phase 1 | Completed | City, University of London | 28 | 2020-06-14 | 2023-05-06 |
| Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders Bioactive Factors, Produced by M2 Type Macrophages (M2-BFs). - Language Delay, Language; Developmental Disorder, Expressive | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 14 | 2020-02-01 | 2022-05-02 |
| Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia F-18 AV 1451 - Primary Progressive Aphasia, Behavioral Variant of Frontotemporal Dementia | Phase 1 | Completed | Mayo Clinic | 81 | 2016-07-01 | 2025-11-21 |
| Brief Behavioral Treatment for Anxiety in Young Children Parent-Led Exposure Therapy, Treatment As Usual - Obsessive-compulsive Disorder, Social Phobia | Phase 1 / Phase 2 | Completed | University of South Florida | 58 | 2014-01-01 | 2016-10-06 |
| Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD C-11 PiB - Atypical Alzheimers Disease, Logopenic Variant of Primary Progressive Aphasia (LPA) | Phase 1 | Completed | Mayo Clinic | 27 | 2012-11-01 | 2015-12-21 |
| Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation HD-tDCS (Soterix), Transcranial Direct Current Stimulation (Neuroconn) - Chronic Aphasia | Phase 1 | Completed | Soterix Medical | 2012-03-01 | 2015-08-26 | |
| Building Complex Language Complex sentence treatment protocol - Language Development Disorders, Learning Disorders | Phase 1 / Phase 2 | Completed | Governors State University | 31 | 2011-04-01 | 2013-11-25 |
| Transcranial Direct Current Stimulation and Aphasia Language Therapy Transcranial Direct Current Stimulation - Cathodal stimulation, Transcranial Direct Current Stimulation - Anodal stimulation, Transcranial Direct Current Stimulation - Sham stimulation - Nonfluent Aphasia, Stroke | Phase 1 | Completed | Shirley Ryan AbilityLab | 12 | 2010-03-01 | 2017-05-15 |
| PiB PET Scanning in Speech and Language Based Dementias C-11 PiB, F-18 FDG - PPA, Primary Progressive Aphasia | Phase 1 | Completed | Mayo Clinic | 168 | 2010-03-01 | 2015-12-22 |
| Davunetide (AL-108) in Predicted Tauopathies - Pilot Study davunetide (AL-108, NAP), Placebo nasal spray - Predicted Tauopathies, Including, Progressive Supranuclear Palsy | Phase 1 | Completed | University of California, San Francisco | 12 | 2010-01-01 | 2019-04-05 |
| My Scrivener® - Measuring Effectiveness and Dose Response in Children My Scrivener(R) - Asperger's Syndrome, Dyslexia | Phase 1 / Phase 2 | Completed | Obslap Research LLC | 176 | 2009-04-01 | 2010-10-28 |
| Implementation of Climb Up Program for Children With Attention Deficit Hyperactivity Disorder (ADHD) and Dyslexia in a School in India Climb Up ADHD and Dyslexia Program - Attention Deficit Hyperactivity Disorder, Dyslexia | Phase 1 / Phase 2 | Completed | Climb Up Kids | 76 | 2007-05-01 | 2015-08-04 |
| Treating Intention In Aphasia: Neuroplastic Substrates Word-finding with intention component, Word-finding with no intention component - Aphasia, Cerebrovascular Accident | Phase 1 / Phase 2 | Completed | University of Florida | 14 | 2007-03-01 | 2012-05-03 |
| Improve Speech Using an In-the-ear Device in Parkinson's Disease SpeechEasy Model ITC - Parkinson's Disease, Dysarthria | Phase 1 | Completed | Rush University Medical Center | 40 | 2006-06-01 | 2013-01-18 |
| Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia. Cortical Electrical Stimulation - Stroke, Broca's Aphasia | Phase 1 | Completed | Northstar Neuroscience | 8 | 2004-12-01 | 2007-09-21 |
| Transcranial Magnetic Stimulation to Improve Speech in Aphasia Transcranial Magnetic Stimulation, Repetitive - Aphasia, Cerebrovascular Stroke | Phase 1 | Completed | Boston University | 63 | 2002-07-01 | 2017-01-31 |
Stroke (7) · Aphasia (6) · Language (4) · Aphasia, Broca (3) · Attention Deficit Disorder with Hyperactivity (3) · Aphasia, Primary Progressive (2) · Dyslexia (2) · Frontotemporal Dementia (2) · Ischemic Stroke (2) · Language Development Disorders (2) · Primary Progressive Nonfluent Aphasia (2) · Speech (2) · Speech Disorders (2) · Anomia (1) · Anorexia (1)
Communication Disorders (17) · Nervous System Diseases (17) · Neurobehavioral Manifestations (17) · Neurologic Manifestations (17) · Pathological Conditions, Signs and Symptoms (17) · Signs and Symptoms (17) · Brain Diseases (12) · Central Nervous System Diseases (12) · Speech Disorders (11) · Mental Disorders (8) · Cardiovascular Diseases (7) · Cerebrovascular Disorders (7) · Vascular Diseases (7) · Behavior (6)
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · Transcranial Direct Current Stimulation (2) · Therapeutics (1) · Transcranial Magnetic Stimulation (1) · davunetide (1)
Mayo Clinic (3) · Boston University (1) · City, University of London (1) · Climb Up Kids (1) · Governors State University (1) · Northstar Neuroscience (1) · Obslap Research LLC (1) · Quadriga Biosciences, Inc. (1) · Rush University Medical Center (1) · Russian Academy of Medical Sciences (1) · Shirley Ryan AbilityLab (1) · Soterix Medical (1) · University of California, San Francisco (1) · University of Florida (1) · University of South Florida (1)
United States (12) · Australia (1) · India (1) · Russia (1) · United Kingdom (1)
Adam L. Boxer, M.D., Ph.D. (1) · Alexander A Ostanin, MD, PhD (1) · Alvaro Pascual-Leone, M.D., Ph.D. (1) · Bruce Crosson, PhD (1) · Catherine H Balthazar, PhD (1) · Cheryl M Scott, PhD (1) · Devendra Mehta, MBBS MSC MRCP (1) · Elena R Chernykh, MD, PhD (1) · Emily Wang, PHD (1) · H B Coslett, M.D. (1) · Jennifer Whitwell, PhD (1) · Julius Fridriksson, PhD (1) · Keith A Josephs, M.D. (1) · Keith A Josephs, M.D. MST, MSc (1) · Leo Verhagen, MD, PHD (1)
PMID 15118944, PMID 15766771, PMID 16006338, PMID 19695692, PMID 20159655, PMID 20299861, PMID 21794852, PMID 21864891, PMID 23106988, PMID 23280015, PMID 26704258, PMID 29256908, PMID 38875279
R01DC005672 (1), R01DC007387 (1), R21DC009876 (1), R21NS094684 (1), R41NS076123 (1)