116 completed, 17 unknown, 14 recruiting, 11 terminated. 41 Not applicable, 30 Phase 4, 29 Phase 2, 17 Phase 3, 12 Phase 1.
Follow this condition Literature Review of Lipodystrophy trials Research Report on Lipodystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Meal Macronutrients on Postprandial Lipids High carb then high fat breakfast, High fat then high carb breakfast - Nephrotic Syndrome, Lipodystrophy | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 100 | 2026-10-26 | 2026-10-21 |
| Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control Study Lipodystrophy Congenital Generalized, Lipodystrophy, Familial Partial | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1416 | 2026-10-01 | 2026-09-02 | |
| Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS) Genetic analysis, Biological analysis, imaging test - Polycystic Ovary Syndrome, Familial Partial Lipodystrophy | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 81 | 2026-07-21 | 2026-08-10 |
| Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy Mibavademab, Placebo - Generalized Lipodystrophy | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 28 | 2026-03-13 | 2026-09-11 |
| Open-label Study to Evaluate Metreleptin in Children Under 6 Years of Age With Generalised Lipodystrophy Metreleptin - Generalized Lipodystrophy | Phase 3 | Terminated | Amryt Pharma | 1 | 2025-05-23 | 2026-07-22 |
| Granzyme B-targeted PET Imaging Monitoring Tumor Responses to Immunotherapy PET/CT Imaging with GZMB-targeted tracer - PET/CT, Solid Tumors, Adult | Not yet recruiting | Zhongnan Hospital | 200 | 2025-04-01 | 2025-04-08 | |
| The Skin Barrier in Users of Diabetes Devices Type 1 Diabetes Mellitus | Recruiting | Jannet Svensson | 150 | 2025-03-10 | 2025-09-09 | |
| The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell Lymphoma T-NK Cell Lymphoma | Not yet recruiting | Ruijin Hospital | 50 | 2025-03-01 | 2025-03-07 | |
| A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD) mibavademab - Generalized Lipodystrophy | Phase 3 | Completed | Regeneron Pharmaceuticals | 9 | 2024-12-16 | 2026-07-29 |
| GzmB-PET/CT to Evaluate Neoadjuvant Therapy Efficacy in Breast Cancer 68Ga-GZMB PET/CT - Breast Cancer Invasive | Recruiting | Shanghai Jiao Tong University School of Medicine | 50 | 2024-11-01 | 2024-12-10 | |
| Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy Metreleptin - Familial Partial Lipodystrophy | Phase 3 | Recruiting | Chiesi Farmaceutici S.p.A. | 24 | 2024-10-14 | 2026-07-16 |
| PET Imaging Targeting Granzyme B Predicts Immunotherapy Efficacy in Diffuse Large B-cell Lymphoma Diffuse Large B-Cell Lymphoma | Recruiting | Ruijin Hospital | 150 | 2024-07-23 | 2025-01-01 | |
| Study of the Subdermal Implant "Ultracol" Administration of the prepared solution - 1 time Post injection observation - 30, 60, 160 days from the date of the first injection. - Skin Aging, Facial Wrinkles | Not applicable | Completed | Estelab Clinic | 23 | 2024-07-16 | 2026-06-01 |
| Study of the Subdermal Implant "Algeness" Algeness Subdermal Implant (Agarose) - Skin Aging, Facial Wrinkles | Not applicable | Completed | Estelab Clinic | 40 | 2024-06-08 | 2026-06-01 |
| The Benefits of the Measureof Epicardial Adipose Tissue During Coronary Calcium Assessment of the Refine Cardiovascular Risk Assessment at Reunion Island. Epicardial adipose tissue measurement on the available tododensitometry used for coronary calcium scoring - High Cholesterol, Lipodystrophy, Familial Partial | Completed | Centre Hospitalier Universitaire de la Réunion | 126 | 2024-05-06 | 2025-07-31 | |
| [68Ga]Ga-GZP PET for Early Response Prediction in Colorectal Cancer During Neoadjuvant Therapy Received 68Ga-NOTA-GZP PET scanning - Colorectal Cancer Control and Prevention, Colorectal Cancer Recurrent | Not applicable | Completed | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 21 | 2024-05-06 | 2025-05-21 |
| Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD) Lipodystrophy | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 14 | 2024-01-03 | 2026-08-18 | |
| Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE" Mediterranean diet, Melatonin supplementation - Obesity, Type2diabetes | Not applicable | Recruiting | Federico II University | 100 | 2023-12-29 | 2025-08-12 |
| Carotid Doppler Peak Velocity Variation in Liposuction Fluid Management Intraoperative fluid ratio, Carotid Artery Doppler Peak Velocity Variation - Lipodystrophy | Not applicable | Completed | TJ Plast Advanced Center for Plastic Surgery | 50 | 2023-11-20 | 2025-04-23 |
| Performance and Safety of the Lipo-transfer Cannulas in Patients Underlying Lipofilling Treatment Lipodystrophy, Deformities | Completed | Aesthetic Group | 108 | 2023-08-30 | 2024-08-01 |
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HIV Infections (59) · HIV-Associated Lipodystrophy Syndrome (25) · Lipodystrophy, Familial Partial (20) · Lipodystrophy, Congenital Generalized (18) · Diabetes Mellitus (15) · Acquired Immunodeficiency Syndrome (14) · Insulin Resistance (14) · Hypertriglyceridemia (11) · Hyperlipidemias (10) · Metabolic Syndrome (7) · Dyslipidemias (6) · Fatty Liver (5) · Non-alcoholic Fatty Liver Disease (5) · Obesity (5)
Nutritional and Metabolic Diseases (169) · Skin Diseases (169) · Skin Diseases, Metabolic (169) · Skin and Connective Tissue Diseases (169) · Lipid Metabolism Disorders (168) · Metabolic Diseases (166) · Urogenital Diseases (79) · Immune System Diseases (78) · Genital Diseases (77) · Blood-Borne Infections (75) · Communicable Diseases (75) · Immunologic Deficiency Syndromes (75) · Infections (75) · Lentivirus Infections (75) · RNA Virus Infections (75)
metreleptin (12) · Lamivudine (8) · Ritonavir (7) · abacavir (7) · efavirenz (6) · Nelfinavir (5) · Zidovudine (5) · tesamorelin (5) · Lopinavir (4) · Nevirapine (4) · Pioglitazone (4) · Pravastatin (4) · Rosiglitazone (4) · Tenofovir (4) · lamivudine, zidovudine drug combination (4)
National Institute of Allergy and Infectious Diseases (NIAID) (15) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (13) · University of Texas Southwestern Medical Center (6) · Assistance Publique - Hôpitaux de Paris (5) · Centre Hospitalier Universitaire de la Réunion (5) · Regeneron Pharmaceuticals (5) · French National Agency for Research on AIDS and Viral Hepatitis (4) · I.R.A. Istituto Ricerche Applicate S.p.A. (4) · Kirby Institute (4) · Massachusetts General Hospital (4) · Glaxo Wellcome (3) · Theratechnologies (3) · University of Michigan (3) · Akcea Therapeutics (2) · Bristol-Myers Squibb (2)
United States (89) · France (22) · Spain (10) · Canada (8) · United Kingdom (8) · Brazil (7) · China (6) · Germany (6) · Italy (5) · Netherlands (5) · Puerto Rico (5) · Reunion (5) · Romania (5) · Russia (5) · Australia (4)
Rebecca J Brown, M.D. (7) · Steven Grinspoon, MD (6) · Mihaela Fratila (4) · Abhimanyu Garg, M.D. (3) · Abhimanyu Garg, MD (3) · Andrew D Carr, MD (3) · David A Cooper, MD (3) · Dominique Costagliola (3) · Grace A. McComsey, MD (3) · Ann-Brit E Hansen, M.D. (2) · Court Pedersen, Professor (2) · Elif A Oral, MD (2) · Grace McComsey, MD (2)
PMID 28324110, PMID 31194872, PMID 34677608, PMID 20101189, PMID 20554713, PMID 22495074, PMID 26589105, PMID 28832410, PMID 34223895, PMID 35788116, PMID 37595266, PMID 16186728, PMID 16218799, PMID 16514303, PMID 16837863, PMID 17434848, PMID 17538545, PMID 18057338, PMID 18167644, PMID 18256394, PMID 18389900, PMID 18519448, PMID 18614924, PMID 18641035, PMID 18677023, PMID 19275490, PMID 19299471, PMID 19321503, PMID 19363330, PMID 19424051, PMID 19455012, PMID 19479079, PMID 19487903, PMID 19727665, PMID 19738484, PMID 19898246, PMID 20168204, PMID 20345880, PMID 20453626, PMID 20467286, PMID 20539305, PMID 20581689, PMID 20631646, PMID 20671544, PMID 20824151, PMID 20827170, PMID 20959530, PMID 20969457, PMID 21081243, PMID 21508633
R01AI060484 (2), 2008 (1), 2015 (1), 2019 (1), K23AI070078 (1), K23DK079789 (1), R01CA229354 (1), R01CA258297 (1), R01DK056583 (1), R01DK058785 (1), R01DK063639 (1), R01DK065515 (1), R01DK088114 (1), R01DK110771 (1), R01HL065953 (1)