120 completed, 14 unknown, 13 terminated, 8 recruiting. 44 Phase 4, 41 Phase 1, 32 Phase 2, 25 Phase 3, 14 Not applicable.
Follow Pravastatin: new trials by email Literature Review of Pravastatin trials Research Report on Pravastatin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran) - Melanoma | Not applicable | Recruiting | University of Colorado, Denver | 40 | 2026-10-19 | 2026-10-22 |
| Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial) Pravastatin 40 mg, Placebo - Preeclampsia (PE), Intrauterine Growth Restriction (IUGR) | Phase 2 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 154 | 2026-01-14 | 2026-10-16 |
| Novel Treatment of Radiation Associated Dysphagia With Statins Pravastatin 40 Mg Oral Tablet - Radiation-associated Dysphagia, Head &Amp; Neck Cancer | Phase 2 | Recruiting | Peter MacCallum Cancer Centre, Australia | 48 | 2025-12-05 | 2026-09-04 |
| Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose) Pravastatin (drug), Pentoxifylline, ketoprofen - Fibrosis Syndrome, Lymphedema | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 250 | 2025-08-08 | 2026-07-24 |
| Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin) - Cardiovascular Diseases (CVD), Drug Effect | Phase 4 | Not yet recruiting | Tor Biering-Sørensen | 42000 | 2025-02-28 | 2025-03-04 |
| Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE) Pravastatin, Pentoxifylline, Tocopherol - Lymphedema, Fibrosis | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 295 | 2025-02-13 | 2026-09-11 |
| StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial Statin (atorvastatin, fluvastatin, pravastatin, rosuvastatin or simvastatin) - Ischemic Stroke, Transient Ischemic Attack | Phase 4 | Not yet recruiting | Prof. dr. Nathalie van der Velde | 612 | 2025-02-01 | 2025-01-21 |
| Statin InTensity to Prevent Coronary Artery Vasculopathy After Heart Transplantation Atorvastatin 80 Mg Oral Tablet, Pravastatin 40 Mg Oral Tablet - Vasculopathy | Not applicable | Withdrawn | Montefiore Medical Center | 2025-01-01 | 2025-01-13 | |
| Statins in Frail Older Patients with Ischemic Stroke or Transient Ischemic Attack - the Prospective Cohort Study Statin - Ischemic Stroke, TIA | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 300 | 2024-11-01 | 2025-01-21 | |
| IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years) - Fontan Circulation | Phase 1 | Recruiting | Children's Mercy Hospital Kansas City | 15 | 2024-03-01 | 2026-01-02 |
| Detoxification From the Lipid Tract electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation - COVID-19 Vaccine Adverse Reaction | Phase 4 | Completed | Pachankis, Yang I., M.D. | 1 | 2024-02-26 | 2024-04-10 |
| A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014) Embibatinib, Rabeprazole, Midazolam - Healthy | Phase 1 | Completed | Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 196 | 2023-12-21 | 2026-10-22 |
| A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants BMS-986196, Caffeine, Montelukast - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 18 | 2023-05-31 | 2023-09-26 |
| Pravastatin as a Prophylactic to Reduce Endothelial Injury in Pediatric Patients With Elevated Body Mass Index Pravastatin - Hematopoietic Stem Cell Transplant (HSCT), Endothelial Injury | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 25 | 2023-01-27 | 2025-04-18 |
| Real World Evidence Study of Statin Use in Brazil Statin - Cardiovascular Diseases, Myocardial Infarction | Completed | Hospital Israelita Albert Einstein | 2133900 | 2021-11-19 | 2024-05-14 | |
| Pravastatin Reduces Acute Phase Response of Zoledronic Acid Pravastatin Sodium 80 MG, Placebo - Postmenopausal Osteoporosis | Phase 4 | Unknown | Peking University Third Hospital | 110 | 2021-11-01 | 2021-06-23 |
| An Observational Study Investigating the Change in Blood Cholesterol With Mevalotin® Tablet Administration in Korean Menopausal Women Aged 50 Years or More Who Require Treatment of Dyslipidemia Mevalotin - Dyslipidemia | Completed | Daiichi Sankyo | 3060 | 2021-08-10 | 2025-07-23 | |
| Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition pravastatin and chenodeoxycholic acid, after metformin and placebo, valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo - Bile Salt Export Pump (BSEP) Transporter, Polysorbate 80 | Phase 4 | Completed | University of Maryland, Baltimore | 18 | 2021-04-01 | 2024-07-16 |
| Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults GSK3640254 200 mg, Caffeine 200 mg, Metoprolol 100 mg - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 20 | 2020-12-16 | 2024-01-05 |
| Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants Atorvastatin, Pravastatin, Rosuvastatin - Rheumatoid Arthritis | Phase 1 | Completed | Gilead Sciences | 27 | 2020-11-04 | 2022-06-14 |
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Hypercholesterolemia (23) · Cardiovascular Diseases (15) · HIV Infections (13) · Hyperlipidemias (12) · Dyslipidemias (11) · Hypertension (8) · Diabetes Mellitus (7) · Coronary Artery Disease (6) · Coronary Disease (6) · Diabetes Mellitus, Type 2 (5) · Heart Diseases (5) · Insulin Resistance (5) · Congenital Abnormalities (4) · Heart Failure (4) · Ischemic Stroke (4)
Yonsei University (7) · Bristol-Myers Squibb (5) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · AstraZeneca (4) · Teva Pharmaceuticals USA (4) · University of Colorado, Denver (4) · Daiichi Sankyo (3) · Fred Hutchinson Cancer Center (3) · Gachon University Gil Medical Center (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Boehringer Ingelheim (2) · Boston Children's Hospital (2) · Brigham and Women's Hospital (2) · Canadian Network for Observational Drug Effect Studies, CNODES (2) · Children's Mercy Hospital Kansas City (2)
United States (66) · South Korea (17) · Canada (13) · France (12) · Netherlands (8) · Japan (6) · Denmark (5) · Germany (5) · South Africa (5) · Spain (5) · Brazil (4) · Russia (4) · Australia (3) · China (3) · Israel (3)
Colin Dormuth, M.Sc., Sc.D. (2) · Dan Yeung, MD (2) · Judith Aberg (2) · Maged Costantine, MD (2) · Nathalie van der Velde, Prof. dr. (2) · Paul Tam, MD (2) · Ralph Scallion EE, MD (2)
PMID 27400896, PMID 36919608, PMID 39356039, PMID 10205010, PMID 16208639, PMID 16218799, PMID 16221223, PMID 16514303, PMID 16651474, PMID 17183151, PMID 17434848, PMID 17434849, PMID 17592099, PMID 17668878, PMID 17846352, PMID 18000186, PMID 18227370, PMID 18279736, PMID 18413554, PMID 18676075, PMID 18772061, PMID 18786751, PMID 19001024, PMID 19926008, PMID 19958964, PMID 20204386, PMID 20395869, PMID 20824151, PMID 21060068, PMID 21345849, PMID 21487089, PMID 21641362, PMID 21969009, PMID 22235820, PMID 22264573, PMID 22318219, PMID 22396585, PMID 22403632, PMID 22431578, PMID 22450943, PMID 22470539, PMID 22490878, PMID 22621316, PMID 22679249, PMID 22739396, PMID 23040716, PMID 23082133, PMID 23194494, PMID 23212806, PMID 23242479
2017 (2), 2005 (1), 2008 (1), M01RR000051 (1), P20RR011104 (1), P30CA015704 (1), P60AR047782 (1), R01AG021570 (1), R01CA218486 (1), R01DK058793 (1), R01HL036392 (1), R01HL063055 (1), R44HL082382 (1), T32HD069038 (1), U01AI068636 (1)