9 completed, 8 recruiting, 5 not yet recruiting, 4 enrolling by invitation. 16 Not applicable, 2 Phase 2, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
Follow Knee Arthritis Osteoarthritis: new trials by email Literature Review of Knee Arthritis Osteoarthritis trials Research Report on Knee Arthritis Osteoarthritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis | Not applicable | Not yet recruiting | McMaster University | 82 | 2027-02-01 | 2026-09-16 |
| Popliteus and Quadriceps Muscle Thickness and Clinical Parameters in Knee Osteoarthritis Knee Arthritis Osteoarthritis, Balance Assessment | Active not recruiting | Afyonkarahisar Health Sciences University | 130 | 2026-08-20 | 2026-09-22 | |
| Is BMI Outdated in TKA Patient Selection? Assessment of the Impact of Pre-tubercular Subcutaneous Tissue Thickness and the Risk of Postoperative Infection Following Total Knee Arthroplasty Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty | Not yet recruiting | East Lancashire Hospitals NHS Trust | 400 | 2026-08-17 | 2026-08-13 | |
| Laser vs Lontophoresis in KOA Low-Level Laser Therapy, Iontophoresis, Conventional Physical Therapy Only - Knee Arthritis Osteoarthritis | Not applicable | Not yet recruiting | Kafrelsheikh University | 66 | 2026-08-01 | 2026-06-24 |
| The Effect of Lipedema on Knee Osteoarthritis Lipedema, Knee Osteoarthritis | Recruiting | Izmir Democracy University | 76 | 2026-07-07 | 2026-07-09 | |
| Condylar Offset and Outcomes in Primary Total Knee Arthroplasty Knee Arthritis Osteoarthritis | Active not recruiting | SB Istanbul Education and Research Hospital | 100 | 2026-05-20 | 2026-10-16 | |
| Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis Perturbation-Based Balance Training, Progressive Neuromuscular Training - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Not applicable | Recruiting | Ibadat International University, Islamabad | 60 | 2026-05-18 | 2026-06-17 |
| An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis Mesenchymal Stem Cells (MSC), Hyaluronic Acid (HA) - Knee Arthritis Osteoarthritis | Phase 2 / Phase 3 | Recruiting | Cellcolabs Clinical SPV Limited | 140 | 2026-04-27 | 2026-04-21 |
| Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities High-Intensity Laser Therapy (HILT), Conventional Physical Therapy Modalities - Knee Arthritis Osteoarthritis | Not applicable | Recruiting | Erbil Polytechnic University | 100 | 2026-04-20 | 2026-04-24 |
| How Patient Education Helps Patients With Chronic Musculoskeletal Disorders Stick to Home Exercise for Pain Relief. Educational with musculoskeletal condition, Standard physical therapy program - Low Back Pain, Knee Arthritis Osteoarthritis | Not applicable | Recruiting | Imam Abdulrahman Bin Faisal University | 120 | 2026-04-12 | 2026-08-13 |
| Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS) Autologous Platelet-Rich Plasma (PRP), Conditioned serum (CS) - Knee Arthritis Osteoarthritis, Platelet Rich Plasma Injection | Not applicable | Recruiting | Pamukkale University | 60 | 2026-04-01 | 2026-08-20 |
| Effects of Motivational Interviewing on Pain Self-Efficacy and Exercise Behavior in Individuals With Knee Osteoarthritis Motivational Interviewing, Neuromuscular Exercise Program, Home Exercise Program - Knee Arthritis Osteoarthritis | Not applicable | Recruiting | Kutahya Health Sciences University | 56 | 2026-02-01 | 2026-08-17 |
| Different Hold Durations in Isometric Exercises isometric exercises, therapeutic ultrasound, Transcutanous electrical nerve stimulation - Knee Arthritis Osteoarthritis | Not applicable | Completed | University of Hail | 127 | 2026-01-30 | 2026-05-11 |
| Effects of 9 Points Electrical Dry Needling in Knee Osteoarthritis 9 points electrical dry needling, Standard physical therapy - Knee Arthritis Osteoarthritis | Not applicable | Not yet recruiting | Riphah International University | 44 | 2026-01-25 | 2026-02-11 |
| Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial) CT-guided Cryoneurolysis of the Genicular Nerves - Arthroplasty, Replacement Material | Not applicable | Recruiting | Attikon Hospital | 100 | 2026-01-02 | 2026-02-20 |
| Effects of Various Types of Ultrasound Therapy in Knee Osteoarthritis Metfomin - Knee Arthritis Osteoarthritis | Not applicable | Completed | Horus University | 80 | 2026-01-01 | 2026-07-31 |
| Comparison Between Velys J&J Robotic-assisted and Cori S&N Robotic-assisted Total Knee Arthroplasty preoperative HKA, preoperative CPAK, preoperative Oxford Knee Score - Knee Arthritis Osteoarthritis | Enrolling by invitation | Jan Biziel University Hospital No 2 in Bydgoszcz | 200 | 2026-01-01 | 2026-06-24 | |
| Handheld MPI Imaging to Track Stem Cells in Osteoarthritis Human Umbilical Cord-derived Mesenchymal Stromal Cells (hUC-MSCs), Ferumoxytol (SPIO) Solution for Injection (Placebo) - Knee Arthritis Osteoarthritis | Early Phase 1 | Enrolling by invitation | Soochow University | 10 | 2025-12-16 | 2026-05-12 |
| Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance Triamcinolone knee injection without ultrasound guidance, Triamcinolone knee injection with ultrasound guidance - Knee Arthritis Osteoarthritis | Phase 4 | Enrolling by invitation | Sosi Dzhugarian | 140 | 2025-12-12 | 2026-04-22 |
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Osteoarthritis, Knee (9) · Osteoarthritis (5) · Agnosia (2) · Arthritis (2) · Chronic Pain (2) · Arm Injuries (1) · Inflammation (1) · Lipedema (1) · Low Back Pain (1) · Motor Activity (1) · Musculoskeletal Diseases (1) · Pain (1) · Pain, Postoperative (1)
Joint Diseases (14) · Musculoskeletal Diseases (13) · Arthritis (12) · Rheumatic Diseases (12) · Osteoarthritis (7) · Pathological Conditions, Signs and Symptoms (7) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Pain (4) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Pathologic Processes (2) · Perceptual Disorders (2) · Back Pain (1) · Behavior (1)
Ultrasonic Therapy (2) · Acupuncture Therapy (1) · Arthroplasty, Replacement, Knee (1) · Electric Stimulation (1) · Exercise (1) · Ferrosoferric Oxide (1) · Hyaluronic Acid (1) · Injections (1) · Iontophoresis (1) · Low-Level Light Therapy (1) · Motivational Interviewing (1) · Physical Therapy Modalities (1) · Solutions (1) · Transcutaneous Electric Nerve Stimulation (1) · ferric oxide (1)
Afyonkarahisar Health Sciences University (1) · Ataturk University (1) · Attikon Hospital (1) · Cellcolabs Clinical SPV Limited (1) · East Lancashire Hospitals NHS Trust (1) · Erbil Polytechnic University (1) · Genascence Corporation (1) · Horus University (1) · Ibadat International University, Islamabad (1) · Imam Abdulrahman Bin Faisal University (1) · Istituto Ortopedico Rizzoli (1) · Izmir Democracy University (1) · Jan Biziel University Hospital No 2 in Bydgoszcz (1) · Kafrelsheikh University (1) · Kanuni Sultan Suleyman Training and Research Hospital (1)
Turkey (Türkiye) (9) · Pakistan (3) · Egypt (2) · Australia (1) · China (1) · Greece (1) · Iraq (1) · Israel (1) · Italy (1) · Poland (1) · Saudi Arabia (1) · United Arab Emirates (1) · United States (1)
Ahmed Bapir, PhD (1) · Charles Hallett, MBBS, MRCS (1) · Griffin Elbert, DO (1) · Gulsah Ozsoy, PhD (1) · Karol Elster, PhD (1) · Lee Hoggett, MBChB, FRCS (1) · Lisa Carlesso (1) · Ola Jeppsson (1) · Stefano Zaffagnini, Full Professor (1)
PMID 12443949, PMID 20451556, PMID 23794645, PMID 24926119, PMID 27351541, PMID 29034226, PMID 31034380, PMID 31278997, PMID 32629325, PMID 37773973, PMID 41604394, PMID 42702647