132 completed, 78 unknown, 30 recruiting, 22 terminated. 114 Not applicable, 43 Phase 3, 40 Phase 2, 14 Phase 1, 6 Phase 4.
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light - Keratoconus | Not applicable | Not yet recruiting | Joseph B. Ciolino, MD | 216 | 2027-01-01 | 2026-04-08 |
| Performance Evaluation of the OCUTOP Hand-held Corneal Topographer OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment) - Corneal Topography, Dry Eye Syndromes | Not applicable | Not yet recruiting | University of Plymouth | 150 | 2027-01-01 | 2026-10-26 |
| Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus NOA lens type 1, NOA lens type 2 - Keratoconus, Presbyopia | Not applicable | Recruiting | Azalea Vision | 16 | 2026-09-28 | 2026-10-13 |
| UNITY DX Cornea Study UNITY DX, ANTERION - Tomography | Recruiting | Alcon Research | 110 | 2026-09-24 | 2026-10-27 | |
| Clinical and Subclinical Keratoconus Cohort Study Keratoconus | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 421 | 2026-09-01 | 2026-04-28 | |
| A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG) | Recruiting | Massachusetts General Hospital | 90 | 2026-08-18 | 2026-08-25 | |
| Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT Corvis Machine - Keratoconus, Intraocular Pressure | Not applicable | Not yet recruiting | Tanta University | 1 | 2026-07-10 | 2026-05-20 |
| Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus Riboflavin Ophthalmic Solutions, UV-A Irradiation System - Keratoconus | Phase 4 | Recruiting | Glaukos Corporation | 15 | 2026-05-11 | 2026-06-05 |
| Outcomes of CTAK Surgery Questionnaire and Physical Exam - Keratoconus, Corneal Ectasia | Phase 4 | Not yet recruiting | Stanford University | 100 | 2026-05-01 | 2026-04-24 |
| Artificial Intelligence-assisted Diagnosis in Ophthalmology No interventions - Macular Degeneration, Diabetic Retinopathy (DR) | Not yet recruiting | Marisse Masis-Solano | 15000 | 2026-05-01 | 2026-04-01 | |
| Study of TN-001 Topical Eyedrops for Keratoconus Low-dose TGF-B3 and Dexamethasone Sodium Phosphate, High-dose TGF-B3 and Dexamethasone Sodium Phosphate - Keratoconus | Phase 1 / Phase 2 | Enrolling by invitation | TheiaNova Ltd. | 20 | 2025-12-23 | 2026-02-04 |
| Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus GLK-221 Ophthalmic Solution, Placebo Ophthalmic Solution - Keratoconus | Phase 2 | Recruiting | Glaukos Corporation | 100 | 2025-12-23 | 2026-02-10 |
| INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia INTACS - Keratoconus | Not applicable | Not yet recruiting | University of California, San Diego | 1000 | 2025-12-01 | 2024-05-07 |
| Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light - Keratoconus, Corneal Ectasia | Phase 2 / Phase 3 | Recruiting | Price Vision Group | 500 | 2025-10-01 | 2026-09-25 |
| PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated - Keratoconus | Not applicable | Recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 50 | 2025-09-01 | 2026-01-28 |
| Keraring Implantation Based on Alfonso Nomogram Intrastromal corneal ring segment implantation (ICRS) - Keratoconic Subjects | Not applicable | Completed | Assiut University | 25 | 2025-09-01 | 2026-10-02 |
| Electrophysiological Changes in Cases of Different Stages of Keratoconus Keratoconus | Active not recruiting | Minia University | 50 | 2025-08-20 | 2026-03-11 | |
| Effect of Corneal and Scleral RGP Lenses on Ocular Health and Visual Quality in Keratoconus Rose K2, Onefit MED - Keratoconus, Irregular Astigmatism | Not applicable | Recruiting | University of Aarhus | 50 | 2025-08-15 | 2025-08-24 |
| Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases Epi-ON corneal cross-linking - Keratoconus, Ectasia of Cornea | Phase 3 | Recruiting | Woolfson Eye Institute | 485 | 2025-08-01 | 2026-02-02 |
| Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome Epi-ON corneal cross-linking (CXL) - Down Syndrome (DS), Keratoconus | Phase 3 | Recruiting | Woolfson Eye Institute | 225 | 2025-08-01 | 2026-02-02 |
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Corneal Diseases (36) · Dilatation, Pathologic (23) · Eye Diseases (10) · Dry Eye Syndromes (9) · Corneal Dystrophies, Hereditary (8) · Glaucoma (7) · Corneal Opacity (6) · Fuchs' Endothelial Dystrophy (5) · Astigmatism (4) · Cataract (4) · Corneal Injuries (4) · Glaucoma, Open-Angle (3) · Macular Degeneration (3) · Corneal Wavefront Aberration (2)
Eye Diseases (287) · Corneal Diseases (261) · Pathological Conditions, Signs and Symptoms (30) · Pathological Conditions, Anatomical (23) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Genetic Diseases, Inborn (15) · Eye Diseases, Hereditary (14) · Lacrimal Apparatus Diseases (9) · Refractive Errors (7) · Nervous System Diseases (6) · Ocular Hypertension (6) · Pathologic Processes (6) · Corneal Dystrophies, Hereditary (5) · Craniocerebral Trauma (4) · Eye Injuries (4)
Corneal Cross-Linking (31) · Riboflavin (28) · Tomography, Optical Coherence (7) · Ophthalmic Solutions (5) · Corneal Topography (4) · prednisolone acetate (4) · Calcium Dobesilate (3) · Dextrans (3) · Flavin Mononucleotide (3) · Keratoplasty, Penetrating (3) · Photorefractive Keratectomy (3) · Surveys and Questionnaires (3) · Drug Implants (2) · Eyeglasses (2) · Fluorometholone (2)
Assiut University (11) · Cornea and Laser Eye Institute (10) · Glaukos Corporation (8) · Democritus University of Thrace (7) · Oregon Health and Science University (6) · Shahid Beheshti University of Medical Sciences (6) · Cxlusa (5) · Federal University of São Paulo (5) · Medical University of Vienna (5) · Zhongshan Ophthalmic Center, Sun Yat-sen University (5) · Instituto de Oftalmología Fundación Conde de Valenciana (4) · Moorfields Eye Hospital NHS Foundation Trust (4) · Umeå University (4) · University Hospital, Montpellier (4) · Centre Hospitalier Régional Metz-Thionville (3)
United States (91) · Egypt (22) · France (22) · Iran (13) · United Kingdom (13) · Brazil (12) · China (12) · Austria (10) · Germany (8) · Greece (6) · Netherlands (6) · Italy (5) · Mexico (5) · Spain (5) · Switzerland (5)
Peter S Hersh, MD (5) · Peter Hersh, MD (4) · Aleksandar Stojanovic, MD (3) · Mahmoud Abdel-Radi, MD (3) · Steven A Greenstein, MD (3) · William Trattler, MD (3) · Yan Wang, Prof (3) · Adimara C Renesto, MD (2) · Bernard Delbosc, MD, PhD (2) · David Huang, MD, PhD (2) · Michael Belin, MD (2) · Mukharram Bikbov, Professor (2) · Parag Majmudar, MD (2) · Peter Hersh, M.D. (2) · Philip Maier, MD (2)
PMID 12719068, PMID 16765803, PMID 16952090, PMID 17531694, PMID 18471635, PMID 20138607, PMID 24452012, PMID 25532633, PMID 32557558, PMID 33591032, PMID 41126474, PMID 10511934, PMID 10548467, PMID 10656302, PMID 10673340, PMID 10951465, PMID 10976937, PMID 11006081, PMID 11165859, PMID 11527942, PMID 11778801, PMID 11778802, PMID 11978762, PMID 12126755, PMID 12213147, PMID 14638698, PMID 14741001, PMID 14745032, PMID 15043821, PMID 15050269, PMID 15068441, PMID 15728537, PMID 16368147, PMID 16565005, PMID 16761238, PMID 16805116, PMID 16814056, PMID 16877401, PMID 16900027, PMID 16936089, PMID 17013692, PMID 17081868, PMID 17224118, PMID 17258522, PMID 17321396, PMID 17413959, PMID 17434435, PMID 17449031, PMID 17457183, PMID 17457184
R01EY018184 (2), R01EY028755 (2), 2015 (1), 2016 (1), 2018 (1), R01EY013178 (1), R01EY019055 (1), R01EY038655 (1)