16 completed, 3 not yet recruiting, 3 unknown, 1 active not recruiting. 14 Not applicable, 2 Early Phase 1, 2 Phase 4, 1 Phase 1, 1 Phase 2.
Follow Intestinal Permeability: new trials by email Literature Review of Intestinal Permeability trials Research Report on Intestinal Permeability
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms After Bariatric Surgery in Body Weight Management Clinical and Biochemical Assessment - Obesity, Morbid, Bariatric Surgery | Not yet recruiting | Toros University | 40 | 2026-07-01 | 2026-06-11 | |
| Fructose and (Aging) Fructose, Glucose - Intestinal Permeability, Immune Response | Not applicable | Recruiting | University of Vienna | 32 | 2026-04-01 | 2026-08-11 |
| Administration of Fiber as a Dietary Supplement to Improve the Management of Alcohol Withdrawal Administration of fibers as a dietary supplement - Alcohol Use Disorder, Supplementation | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 138 | 2026-02-01 | 2026-01-27 |
| Ulcerative Colitis Permeability Ulcerative Colitis (UC), Steatotic Liver Disease | Enrolling by invitation | University Hospital Dubrava | 100 | 2025-12-01 | 2026-06-25 | |
| Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research. Aspirin, Mixed meal beverage - Intestinal Permeability | Not applicable | Completed | Laval University | 10 | 2025-07-07 | 2025-09-25 |
| Dietary Supplements for Reduction of Intestinal Permeability Levels Dietary supplement Group - Intestinal Permeability, Leaky Gut Syndrome | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 85 | 2025-02-01 | 2025-01-06 |
| Effect Of The Mediterranean Diet On Zonulin And Infertility mediterranean diet - Infertility Female, Zonulin | Not applicable | Completed | SINEM BAYRAM | 22 | 2024-02-10 | 2025-07-18 |
| Dietary Supplementation on Gastrointestinal Barrier Function plant derived phenolics, Microcrystaline cellulose (MCC) - Intestinal Permeability | Not applicable | Unknown | Brightseed | 126 | 2024-02-06 | 2024-03-08 |
| Effect of Chokeberry Supplementation on Oxidative Stress and Gut Integrity in Swimmers. Black chokeberry extract in capsules with 18% standardization of the anthocyanins content, Chokeberry fiber in capsules - Stress Oxidative, Intestinal Permeability | Phase 4 | Completed | Poznan University of Physical Education | 22 | 2023-03-01 | 2025-07-08 |
| WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine - Inflammation, Vaccine | Early Phase 1 | Completed | USDA, Western Human Nutrition Research Center | 60 | 2022-09-27 | 2025-12-17 |
| Sucralose and Glucose Metabolism in Young Healthy Adults Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ) - Glucose Intolerance, Glucose and Insulin Response | Not applicable | Completed | University of Ottawa | 42 | 2022-03-16 | 2026-05-12 |
| Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB) Semaglutide, Placebo - Type 2 Diabetes, Chronic Inflammation | Phase 4 | Completed | University of Colorado, Denver | 69 | 2022-01-01 | 2025-03-20 |
| Gut Permeability and Bariatric-metabolic Surgery NASH - Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate | Unknown | Medical University of Vienna | 125 | 2021-05-01 | 2024-03-20 | |
| Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling - Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation | Not applicable | Completed | Serap Balaban Barta | 40 | 2020-12-15 | 2026-03-27 |
| Induction of Gut Permeability by an Oral Vaccine Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control) - Intestinal Permeability, Inflammation | Early Phase 1 | Active not recruiting | USDA, Western Human Nutrition Research Center | 10 | 2019-12-04 | 2026-11-12 |
| The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults Cranberry Beverage, Control Beverage - Intestinal Permeability, Gastrointestinal Function | Not applicable | Completed | University of Florida | 43 | 2019-09-05 | 2020-01-07 |
| Labelled Carbon Sucrose Breath Test (13C-SBT) as a Marker of Environmental Enteropathy Glucose-Galactose Malabsorption, Enteropathy | Unknown | University of Virginia | 600 | 2019-09-01 | 2021-10-06 | |
| The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy Probiotic - Intestinal Permeability, Gastrointestinal Irritation | Not applicable | Completed | University of Copenhagen | 5 | 2018-07-01 | 2019-04-18 |
| Trial of Enteral Glutamine on Intestinal Permeability in Critically Ill Patients Glutamin, Maltodextrin - Critical Illness, Enteral Nutrition | Phase 3 | Completed | Shahid Beheshti University | 60 | 2017-04-01 | 2018-04-10 |
| The Effect of Probiotic Intervention on Intestinal Permeability Probiotic, Placebo - Intestinal Permeability | Not applicable | Completed | Chr Hansen | 251 | 2017-03-01 | 2018-05-03 |
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Inflammation (6) · Diabetes Mellitus, Type 2 (4) · Obesity (3) · Insulin Resistance (2) · Typhoid Fever (2) · Alcoholism (1) · Cardiovascular Diseases (1) · Child Nutrition Disorders (1) · Colitis, Ulcerative (1) · Critical Illness (1) · Diabetes Mellitus (1) · Failure to Thrive (1) · Glucose Intolerance (1) · Glucose-Galactose Malabsorption (1) · Infertility, Female (1)
Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (8) · Nutritional and Metabolic Diseases (7) · Glucose Metabolism Disorders (6) · Metabolic Diseases (6) · Nutrition Disorders (5) · Signs and Symptoms (5) · Body Weight (4) · Digestive System Diseases (4) · Endocrine System Diseases (4) · Overnutrition (4) · Overweight (4) · Diabetes Mellitus (3) · Gastrointestinal Diseases (3) · Hyperinsulinism (3)
Aspirin (2) · Probiotics (2) · maltodextrin (2) · Capsules (1) · Cholecalciferol (1) · Diet (1) · Diet Records (1) · Diet, Mediterranean (1) · Fructose (1) · Glucose (1) · Glutamine (1) · Inulin (1) · SSB protein, human (1) · Ty21a typhoid vaccine (1) · glutamin-(asparagin-)ase (1)
Fred Hutchinson Cancer Center (2) · TNO (2) · USDA, Western Human Nutrition Research Center (2) · Assistance Publique - Hôpitaux de Paris (1) · Brightseed (1) · Chr Hansen (1) · Laval University (1) · Medical University of Vienna (1) · Poznan University of Physical Education (1) · SINEM BAYRAM (1) · Serap Balaban Barta (1) · Shahid Beheshti University (1) · Toros University (1) · Universidad Complutense de Madrid (1) · University Hospital Dubrava (1)
United States (8) · Turkey (Türkiye) (3) · Austria (2) · Canada (2) · Netherlands (2) · Australia (1) · Bangladesh (1) · Croatia (1) · Denmark (1) · India (1) · Iran (1) · Ireland (1) · Jamaica (1) · Kenya (1) · Peru (1)
Danielle Lemay, PhD (2) · W J Pasman, PhD (2) · Alain Veilleux, PhD (1) · Alessio Fasano, MD (1) · Bess Caswell, PhD (1) · Bobbi Langkamp-Henken, PhD (1) · Fergus Shanahan, Professor (1) · Jens R Andersen, MD,MPA (1) · Joseph Onyiah, MD (1) · Mario Kratz, MS, PhD (1) · Mario Kratz, Ph.D. (1)
PMID 11193578, PMID 16265432, PMID 19805376, PMID 21248165, PMID 25676324, PMID 28159311, PMID 33184642, PMID 33203623, PMID 35866597, PMID 37070830, PMID 39384142, PMID 39397156, PMID 42099915
R21HL108257 (1)