136 completed, 22 unknown, 19 recruiting, 11 terminated. 142 Not applicable, 11 Phase 2, 8 Phase 4, 7 Phase 1, 6 Early Phase 1.
Follow Insulin Sensitivity: new trials by email Literature Review of Insulin Sensitivity trials Research Report on Insulin Sensitivity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in Adolescents Circadian/Sleep (C/S) - Overweight Adolescents, Sleep | Not applicable | Recruiting | University of Colorado, Denver | 60 | 2026-10-20 | 2026-11-05 |
| Diaplex and Glycemic Control Diaplex, Placebo - Insulin Sensitivity, Healthy Adult | Not applicable | Not yet recruiting | Standard Process Inc. | 40 | 2026-09-01 | 2026-07-17 |
| The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight Spiroergometer test with intranasal insulin spray, Spiroergometer test with intranasal placebo spray - Insulin Sensitivity | Not applicable | Not yet recruiting | University of Ulm | 8 | 2026-04-01 | 2026-03-16 |
| Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition Physiological Insulin Intervention - Alzheimer s Disease, Alzheimer Blood Biomarkers | Not applicable | Recruiting | Pennington Biomedical Research Center | 8 | 2025-12-01 | 2025-12-04 |
| The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation Colchicin 0.5 mg once daily for two weeks, then twice daily for two weeks, Placebo once daily for two weeks, then twice daily for two weeks, Colchicine tablet 0.5 mg once-daily for two weeks, then twice daily for two weeks - Type 1 Diabetes, Chronic Inflammation | Phase 2 | Recruiting | Asger Lund, MD | 26 | 2025-12-01 | 2025-12-23 |
| Insulin Sensitivity and Testosterone Response to Aerobic Exercise Versus Added Sugar Elimination in Polycystic Ovary Syndrome Women aerobic exercise, added sugar elimination, aerobic exercise and added sugar elimination - Insulin Sensitivity | Not applicable | Not yet recruiting | Cairo University | 60 | 2025-08-20 | 2025-08-24 |
| Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial ESG + lifestyle modification, Lifestyle modification - Obesity, Liver Diseases | Not applicable | Recruiting | Pichamol Jirapinyo, MD, MPH | 132 | 2025-06-24 | 2026-06-25 |
| A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus Retatrutide, Semaglutide, Placebo - Diabetes Mellitus, Insulin Sensitivity | Phase 1 | Active not recruiting | Eli Lilly and Company | 95 | 2025-06-02 | 2026-10-06 |
| Evaluation of Molecular Hydrogen Supplementation to Enhance the Efficacy of Weight Loss Retreat in Overweight and Obese Adolescents Hydrogen-rich water, Placebo - Body Composition, Fitness | Not applicable | Active not recruiting | Palacky University | 60 | 2025-05-12 | 2026-06-02 |
| Physical Activity and Insulin Sensitivity Dynamics One-legged-knee extensor exercise, Insulin infusion, Muscle Biopsy Medication: Lidocaine - Insulin Sensitivity | Not applicable | Recruiting | University of Copenhagen | 8 | 2025-05-05 | 2025-12-02 |
| Topical Insulin for Ocular Surface Interface in Dry Eye Disease Artificial tear, insulin human - Dry Eye, Insulin Sensitivity | Phase 4 | Completed | Khyber Teaching Hospital | 128 | 2025-04-14 | 2026-08-14 |
| Aging Resilience Through Microbiota Optimization and Regulation FMT capsule, Placebo Capsule(s) - Resilience, Cognitive Function and Well-Being | Phase 1 | Active not recruiting | Gonzalo Jorquera, PhD | 80 | 2025-01-10 | 2026-07-29 |
| The Importance of Insulin Action in the Brain for the Immune System During Physical Activity Spiroergometer test with intranasal insulin spray, Spiroergometer test with intranasal placebo spray - Insulin Sensitivity | Not applicable | Active not recruiting | University of Ulm | 20 | 2024-12-15 | 2025-12-10 |
| Metabolic Adaptations to High-fat Diet Hypercaloric, High Fat Diet - Adiposity, Insulin Sensitivity | Not applicable | Terminated | George Washington University | 2 | 2024-08-12 | 2025-08-26 |
| Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness Subcutaneous GLP1-RA, Subcutaneous placebo - Normal Weight, Overweight and Obesity | Not applicable | Recruiting | University Hospital Tuebingen | 60 | 2024-07-01 | 2025-03-30 |
| Effects of Fasted- Versus Fed-exercise on Metabolic Health in Physically Active Adults Fasted-exercise, Fed-exercise - Glucose Levels, Lipid Profile | Not applicable | Completed | National Taiwan Normal University | 16 | 2024-04-04 | 2025-05-02 |
| Effect of Pulsatile Hormone Administration on Insulin Action Continuous Insulin administration during hyperinsulinemic euglycemic clamp test, Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test - Insulin Sensitivity | Not applicable | Completed | Pennington Biomedical Research Center | 4 | 2024-03-04 | 2026-09-04 |
| Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers Time-restricted eating, Control eating - Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease | Not applicable | Recruiting | Colorado State University | 50 | 2024-03-01 | 2025-12-17 |
| Effect of Sleep Extension on Ceramides in People With Overweight and Obesity Sleep Extension Intervention - Lifestyle Factors, Overweight and Obesity | Not applicable | Recruiting | University of Utah | 70 | 2024-02-12 | 2026-08-05 |
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Insulin Resistance (208) · Obesity (48) · Diabetes Mellitus, Type 2 (24) · Motor Activity (18) · Glucose Intolerance (17) · Inflammation (12) · Metabolic Syndrome (10) · Overweight (10) · Glucose Metabolism Disorders (9) · Metabolic Diseases (9) · Diabetes Mellitus (8) · Obesity, Abdominal (7) · Hyperglycemia (6) · Hypertension (5) · Polycystic Ovary Syndrome (5)
Nutritional and Metabolic Diseases (207) · Hyperinsulinism (205) · Glucose Metabolism Disorders (199) · Metabolic Diseases (199) · Pathological Conditions, Signs and Symptoms (71) · Signs and Symptoms (62) · Body Weight (56) · Nutrition Disorders (56) · Overnutrition (54) · Overweight (45) · Endocrine System Diseases (42) · Behavior (30) · Diabetes Mellitus (29) · Pathologic Processes (17) · Hyperglycemia (16)
Exercise (19) · Metformin (10) · Diet (4) · Glucose (4) · Insulin (4) · Caloric Restriction (3) · Diet, High-Fat (3) · Sodium Chloride (3) · Biguanides (2) · E5564 (2) · Ergocalciferols (2) · High-Intensity Interval Training (2) · Insulin Infusion Systems (2) · Pioglitazone (2) · Resistance Training (2)
University of Copenhagen (10) · Pennington Biomedical Research Center (8) · The University of Texas Health Science Center at San Antonio (7) · University of Alabama at Birmingham (6) · University of Colorado, Denver (6) · Maastricht University Medical Center (5) · University Hospital Tuebingen (5) · Colorado State University (4) · University of Aarhus (4) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (3) · Bogomolets National Medical University (3) · Stanford University (3) · University of Utah (3) · University of Virginia (3) · Virginia Commonwealth University (3)
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Martin Heni, MD (3) · Nazarii Kobyliak, PhD (3) · Ralph DeFronzo, MD (3) · Ambika Ashraf, MD (2) · Kai Cheang, Pharm. D. (2) · Lauren B Shomaker, PhD (2) · Nicolas Musi, MD (2) · Nicolas Musi, MD. (2) · Norman K Pollock, Ph.D. (2) · Robin P Shook, PhD (2) · Sean Iwamoto, MD (2) · Tracey McLaughlin, MD (2) · Adam Konopka, PhD (1) · Agneta L Sunehag, M.D., Ph.D (1) · Aimilia Papakonstantinou, PhD (1)
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