6 completed, 2 withdrawn, 1 recruiting, 1 terminated. 11 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 6, Withdrawn 2, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
Follow Insulin Sensitivity: new trials by email Literature Review of Insulin Sensitivity trials Research Report on Insulin Sensitivity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation Colchicin 0.5 mg once daily for two weeks, then twice daily for two weeks, Placebo once daily for two weeks, then twice daily for two weeks, Colchicine tablet 0.5 mg once-daily for two weeks, then twice daily for two weeks - Type 1 Diabetes, Chronic Inflammation | Phase 2 | Recruiting | Asger Lund, MD | 26 | 2025-12-01 | 2025-12-23 |
| Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg - Impaired Glucose Tolerance, Insulin Sensitivity | Phase 2 | Unknown | Oslo University Hospital | 64 | 2021-02-10 | 2021-04-08 |
| Insulin Signaling in Skeletal Muscle Metformin, Pioglitazone, Placebo - Insulin Sensitivity | Phase 2 / Phase 3 | Withdrawn | Wayne State University | 2019-09-01 | 2020-10-08 | |
| The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects Eritoran, D5W - Insulin Sensitivity | Phase 2 | Terminated | The University of Texas Health Science Center at San Antonio | 15 | 2015-01-01 | 2020-03-04 |
| The Role of TLR4 on Lipid-induced Insulin Resistance Eritoran, D5W (5% Dextrose in water) - Insulin Sensitivity | Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 10 | 2015-01-01 | 2019-10-08 |
| Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2) Maltodextrin, Synbiotic, Sevelamer - Insulin Sensitivity | Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 69 | 2014-04-10 | 2020-09-11 |
| Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim 1) Sevelamer, Synbiotic, Maltodextrin - Insulin Sensitivity | Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 20 | 2014-04-02 | 2021-10-15 |
| Vitamin D AND Glucose Handling Evaluated by Glucose Clamp cholecalciferol - Insulin Sensitivity, Intraocular Pressure | Phase 2 | Completed | University Hospital of North Norway | 160 | 2008-11-01 | 2011-11-03 |
| Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers Intralipid, ClinOleic, Dextrose - Diseases, Metabolic, Insulin Sensitivity | Phase 2 / Phase 3 | Completed | Emory University | 12 | 2008-06-01 | 2014-12-31 |
| The Effect of Gemcabene on Insulin Sensitivity in Nondiabetic Subjects Gemcabene 900 mg, Placebo - Insulin Sensitivity | Phase 2 | Completed | NeuroBo Pharmaceuticals Inc. | 53 | 2001-07-01 | 2020-04-09 |
Insulin Resistance (11) · Glucose Intolerance (2) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Glucose Metabolism Disorders (1) · Hyperinsulinism (1) · Hypertension (1) · Metabolic Diseases (1)
Nutritional and Metabolic Diseases (11) · Glucose Metabolism Disorders (10) · Hyperinsulinism (10) · Metabolic Diseases (10) · Diabetes Mellitus (2) · Endocrine System Diseases (2) · Hyperglycemia (2) · Autoimmune Diseases (1) · Cardiovascular Diseases (1) · Immune System Diseases (1) · Vascular Diseases (1)
E5564 (2) · Glucose (2) · Metformin (2) · Sevelamer (2) · Synbiotics (2) · eritoran (2) · maltodextrin (2) · Biguanides (1) · Cholecalciferol (1) · ClinOleic (1) · Colchicine (1) · Diet (1) · Diet, Fat-Restricted (1) · Diet, High-Fat (1) · Pioglitazone (1)
The University of Texas Health Science Center at San Antonio (4) · Asger Lund, MD (1) · Emory University (1) · NeuroBo Pharmaceuticals Inc. (1) · Oslo University Hospital (1) · University Hospital of North Norway (1) · University of Arizona (1) · Wayne State University (1)
United States (5) · Norway (2) · Denmark (1)
Nicolas Musi, MD (2) · Nicolas Musi, MD. (2) · Asger B Lund, MD, PhD (1) · Benjamin J Renquist, PhD (1) · Guillermo Umpierrez, MD (1) · Rolf Jorde, Professor (1)
PMID 36066991, PMID 21832112, PMID 21911741, PMID 42141362
2025 (1)