154 completed. 154 Phase 1, 46 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 154 | Completed 154 |
| Phase 2 | 46 | Completed 46 |
Follow Insulin Resistance: new trials by email Literature Review of Insulin Resistance trials Research Report on Insulin Resistance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500 Portal Insulin U-500, Humulin R U-500, Lyumjev U-100 Insulin - Type 1 Diabetes | Phase 1 | Completed | Portal Diabetes, Inc. | 29 | 2026-02-10 | 2026-11-04 |
| Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes Diluted Humalog U-200 Insulin, Diluted U-500 Humulin Insulin, Lyumjev U-100 Insulin - Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus | Phase 1 | Completed | Stanford University | 10 | 2025-10-28 | 2026-07-08 |
| Effect of NAE on Polycystic Ovarian Syndrome (PCOS) Herbal Formulation, Metformin XR, Metformin 750 mg and herbal formulation 500 mg - Polycystic Ovarian Syndrome (PCOS), Infertility | Phase 1 | Completed | Jinnah Sindh Medical University | 116 | 2025-04-10 | 2026-06-22 |
| A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus LY3209590 - Type 2 Diabetes Mellitus | Phase 1 | Completed | Eli Lilly and Company | 15 | 2024-10-10 | 2026-03-24 |
| Graded Insulin Suppression Test P&F Insulin regular, 2.0-3.2 mU/m2/min (euinsulinemia), Insulin regular, 32 mU/m2/min (hyperinsulinemia), Octreotide Acetate, 6-45 ng/kg/min - Insulin Resistance, Hyperinsulinemia | Phase 1 | Completed | Columbia University | 20 | 2024-09-16 | 2026-10-16 |
| Pancreatic Clamp in NAFLD Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Prediabetic State | Phase 1 | Completed | Columbia University | 18 | 2023-08-29 | 2026-01-12 |
| Glycemic Effect of Diazoxide in NAFLD Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, Placebo - Hyperinsulinemia, Insulin Resistance | Phase 1 | Completed | Columbia University | 22 | 2023-08-01 | 2026-09-30 |
| Effect of Alpelisib in Healthy Volunteers Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg), Placebo (microcrystalline cellulose), 2 capsules, FreeStyle Libre Pro - Insulin Resistance, Hyperinsulinemia | Phase 1 | Completed | Columbia University | 23 | 2023-05-09 | 2023-12-21 |
| Strawberries and Risk of Diabetes in Adults Freeze-dried strawberry powder - PreDiabetes, Metabolic Syndrome | Phase 1 | Completed | University of Nevada, Las Vegas | 39 | 2023-01-01 | 2025-05-18 |
| The Effect of Biktarvy (B/F/TAF) on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers BIKTARVY 50Mg-200Mg-25Mg Tablet - HIV-1-infection | Phase 1 | Completed | Chelsea and Westminster NHS Foundation Trust | 25 | 2022-12-22 | 2024-12-10 |
| The Effects of Glucagon on Hepatic Metabolism Glucagon response study - Obesity, Type2diabetes | Phase 1 / Phase 2 | Completed | Adrian Vella | 21 | 2022-10-20 | 2026-11-04 |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (PEG)-BHD1028 (PEG)-BHD1028 Single Ascending Dose, (PEG)-BHD1028 Multiple Ascending Dose, Placebo - Insulin Resistance | Phase 1 | Completed | EncuraGen, Inc | 64 | 2022-04-18 | 2024-08-20 |
| The Effect of Dolutegravir on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers Dolutegravir - HIV-1-infection on Healthy Volunteers | Phase 1 | Completed | Chelsea and Westminster NHS Foundation Trust | 16 | 2022-03-20 | 2025-12-02 |
| A Study to Explore the PK and PD of INV-202 in Metabolic Syndrome INV-202, Placebo - Metabolic Syndrome | Phase 1 | Completed | Inversago Pharma Inc. | 37 | 2022-03-01 | 2025-03-27 |
| Food Intake and Intra-Nasal Insulin for African American Adults (FIINAAL) Insulin, Regular, Human, Placebo - Insulin | Phase 1 | Completed | Pennington Biomedical Research Center | 40 | 2021-06-17 | 2023-11-29 |
| Low Dose Empagliflozin in Adults With Type 1 Diabetes on Closed Loop Insulin System 14-day outpatient intervention - Type 1 Diabetes | Phase 1 | Completed | McGill University | 25 | 2020-11-02 | 2022-10-12 |
| Pharmacodynamics and Pharmacokinetics of 3 New Developed Coated Glucose Beads in 20 Obese Healthy Subjects coated beads glucose (8 g) and caffeine anhydrous, coated beads glucose (8 g), uncoated beads glucose (8 g) and caffeine anhydrous - Metabolic Syndrome, Obesity | Phase 1 | Completed | Aphaia Pharma US LLC | 20 | 2019-10-25 | 2023-02-06 |
| Metabolic Effects of Melatonin Treatment Melatonin, Placebo Oral Tablet - Metabolic Disease, Insulin Sensitivity | Phase 1 | Completed | University of Aarhus | 17 | 2019-09-26 | 2021-08-25 |
| PK/PD Study of Gan & Lee Insulin Aspart Injection vs. US & EU NovoLog®/NovoRapid® in Healthy Males Gan & Lee Insulin Aspart - Diabetes Mellitus, Type 1 | Phase 1 | Completed | Gan and Lee Pharmaceuticals, USA | 36 | 2019-08-27 | 2020-02-13 |
| PK/PD Biosimilarity Study of Gan & Lee Insulin Lispro Injection vs. EU and US Humalog® in Healthy Males Gan & Lee Insulin Lispro Injection - Diabetes Mellitus | Phase 1 | Completed | Gan and Lee Pharmaceuticals, USA | 36 | 2019-04-23 | 2020-02-13 |
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Metabolic Syndrome (38) · Obesity (30) · Diabetes Mellitus (27) · Diabetes Mellitus, Type 2 (24) · Diabetes Mellitus, Type 1 (14) · Inflammation (9) · Prediabetic State (8) · Hypertension (7) · Glucose Intolerance (5) · HIV Infections (5) · Hyperinsulinism (5) · Hyperlipidemias (5) · Metabolic Diseases (5) · Non-alcoholic Fatty Liver Disease (5)
Nutritional and Metabolic Diseases (154) · Glucose Metabolism Disorders (151) · Hyperinsulinism (149) · Metabolic Diseases (149) · Endocrine System Diseases (67) · Pathological Conditions, Signs and Symptoms (47) · Signs and Symptoms (38) · Diabetes Mellitus (36) · Body Weight (34) · Nutrition Disorders (33) · Overnutrition (32) · Overweight (30) · Immune System Diseases (20) · Autoimmune Diseases (15)
Insulin (15) · Insulin Lispro (6) · Metformin (6) · Exercise (4) · Rosiglitazone (4) · Sodium Chloride (4) · Glucagon (3) · Glucose (3) · Insulin, Regular, Human (3) · beta-lapachone (3) · gallium nitrate (3) · xenin 25 (3) · 17-ethynyl-5-androstene-3, 7, 17-triol (2) · Asian ginseng (2) · Atorvastatin (2)
Columbia University (5) · Stanford University (5) · Halozyme Therapeutics (4) · Mayo Clinic (4) · Vanderbilt University Medical Center (4) · Gan and Lee Pharmaceuticals, USA (3) · Hanoi Medical University (3) · National Center for Complementary and Integrative Health (NCCIH) (3) · University of Aarhus (3) · University of California, San Francisco (3) · Washington University School of Medicine (3) · Yungjin Pharm. Co., Ltd. (3) · Albert Einstein College of Medicine (2) · Chelsea and Westminster NHS Foundation Trust (2) · Eli Lilly and Company (2)
United States (89) · Canada (12) · Germany (9) · United Kingdom (7) · Denmark (4) · Sweden (3) · Vietnam (3) · France (2) · Netherlands (2) · Pakistan (2) · South Korea (2) · Australia (1) · Brazil (1) · Cameroon (1) · Czechia (1)
Dominic Reeds, MD (3) · Joshua R Cook, MD, PhD (3) · Burton Wice, PhD (2) · Cyndya Shibao, MD (2) · Dwight R. Stickney, MD (2) · Jack A Yanovski, M.D. (2) · Jia Lu, PhD (2) · Joerg Schirra, MD (2) · Kyung-Sang Yu, Professor (2) · Yoghatama Cindya Zanzer, MSc (2) · Adrian Vella (1) · Ahmad Haidar, PhD (1) · Alex Calizzano, MD (1) · Alka M. Kanaya, MD (1)
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