41 completed, 11 unknown, 7 recruiting, 5 not yet recruiting. 56 Not applicable, 10 Phase 2, 5 Phase 3, 3 Phase 4, 2 Phase 1.
Follow Synbiotics: new trials by email Literature Review of Synbiotics trials Research Report on Synbiotics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness Synbiotic, Standard of Care (SOC) - Critical Illness | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 64 | 2027-01-01 | 2026-09-10 |
| Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type: - Cognitive Impairment | Not applicable | Recruiting | Anahuac University | 20 | 2026-12-31 | 2026-09-14 |
| Synbiotic as an Adjuvant Therapy for Dyslipidaemia and Gut Health Synbiotic (LAB12 and SWEOAT® Bran), Oat-based Placebo - Dyslipidemia | Phase 2 | Not yet recruiting | Universiti Teknologi Mara | 190 | 2026-12-02 | 2026-11-05 |
| Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) - Obesity (Disorder) | Not applicable | Recruiting | Anahuac University | 40 | 2026-11-01 | 2026-09-10 |
| Effects of Synbiotic Supplementation on Gastrointestinal Symptoms, Appetite, and Nutritional Recovery in Patients After Autologous Bone Marrow Transplant Tri-component Synbiotic Supplement - Hematologic Neoplasms, Gastrointestinal Symptoms | Not applicable | Not yet recruiting | Alexandria University | 40 | 2026-10-01 | 2026-10-01 |
| The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight Synbiotic, Placebo - Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms | Not applicable | Recruiting | Chr Hansen - part of Novonesis | 90 | 2026-03-18 | 2026-04-15 |
| Impact of Supplementation With Synbiotics and Prebiotics on Cognitive Decline Associated With Neoadjuvant Chemotherapy in First-line Patients With Breast Cancer Synbiotics Blend, Synbiotics + Vitamin D, Prebiotic - Chemobrain, Breast Cancer | Not applicable | Enrolling by invitation | Instituto Jalisciense de Cancerologia | 80 | 2026-02-27 | 2026-03-12 |
| Effect of follow-on Formula on the Gut Microbiota of Healthy Infants. Test: Follow-on formula with synbiotics, Control: Regular follow-on formula - Follow-on Formula, Infant | Not applicable | Active not recruiting | Nutricia Research | 268 | 2025-12-23 | 2026-10-08 |
| Probiotic and Prebiotic Supplementation in Peritoneal Dialysis Patients Synbiotic, Placebo - Chronic Kidney Disease (Stages 4 and 5), Peritoneal Dialysis (PD) | Not applicable | Recruiting | Hospital Universitario Dr. Jose E. Gonzalez | 60 | 2025-10-03 | 2026-07-10 |
| The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health Synbiotic, Placebo - Hypertension, Gut Dysbiosis | Not applicable | Completed | Southern Utah University | 47 | 2025-09-01 | 2026-07-29 |
| Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity. Synbiotic, Placebo - Obese Patients (BMI ≥ 30 kg/m²), Anxiety | Not applicable | Recruiting | Celia Bañuls | 120 | 2025-04-15 | 2026-09-08 |
| NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood Synbiotic, Placebo - Sleep Problem, Neurobehavioral Manifestations | Not applicable | Not yet recruiting | Petra Zimmermann | 380 | 2025-03-01 | 2025-02-20 |
| Evaluating the Impact of Synbiotic Supplementation on Infants and Toddlers Synbiotic Supplement, Lactose (inactive placebo) - Gastrointestinal Tolerance of Probiotics in Infants | Not applicable | Completed | Persephone Biosciences | 110 | 2025-01-01 | 2026-08-25 |
| Effects of Synbiotics on Obesity Placebo, Synbiotics - Obesity | Phase 2 | Not yet recruiting | Leeuwenhoek Laboratories Co. Ltd. | 80 | 2024-10-15 | 2024-10-09 |
| Evaluating the Effects of a Synbiotic Versus Probiotic or Placebo on Gut Microbiota and Cardiometabolic Health: A Randomized Double-Blind Placebo Controlled Trial Synbiotic, Probiotic, Placebo - Blood Pressure, Body Composition, Immune Function | Not applicable | Unknown | Skidmore College | 60 | 2024-07-23 | 2024-08-09 |
| Synbiotic Supplementation in Cyclists Synbiotic, Placebo - Exercise Endurance | Not applicable | Completed | University of Calgary | 22 | 2024-07-15 | 2026-05-01 |
| Efficacy of Seluang Fish Oil (Rasbora Argyrotaenia) and Synbiotics Supplementation on CD4+CD25+ Foxp3+ T-regulator Cells, IL17/IL-10 Ratio, and Disease Activity in Systemic Lupus Erythematosus Patients Seluang fish oil (Rasbora argyrotaenia) and synbiotic, Placebo - Systemic Lupus Erythematosus (SLE) | Not applicable | Active not recruiting | Universitas Sriwijaya | 40 | 2024-05-16 | 2024-10-26 |
| Impact of Nutritional Intervention With Probiotics and Prebiotics on Obesity. Probiotic, Prebiotic, Synbiotic - Obesity and Overweight, Obesity, Morbid | Not applicable | Enrolling by invitation | Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental | 230 | 2024-02-01 | 2025-04-11 |
| The Synbiotics Effects in Polycystic Ovary Syndrome: A Randomized Controlled Trial synbiotics, placebo - PCOS- Polycystic Ovary Syndrome | Not applicable | Unknown | Maharaj Nakorn Chiang Mai Hospital | 40 | 2024-01-01 | 2023-12-13 |
| The Effects of Synbiotic on Cardiovascular and Bone Metabolism Markers in Transplanted Kidney Patients synbiotic, placebo - Transplanted Kidney | Not applicable | Unknown | National Nutrition and Food Technology Institute | 44 | 2023-12-01 | 2023-12-07 |
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Obesity (13) · Inflammation (4) · Insulin Resistance (4) · Metabolic Syndrome (4) · Anxiety Disorders (3) · Non-alcoholic Fatty Liver Disease (3) · Overweight (3) · Renal Insufficiency, Chronic (3) · Body Weight (2) · Cognitive Dysfunction (2) · Communicable Diseases (2) · Crohn Disease (2) · Depression (2) · Lupus Erythematosus, Systemic (2) · Obesity, Morbid (2)
National Nutrition and Food Technology Institute (4) · Société des Produits Nestlé (SPN) (4) · Federico II University (3) · University of Dundee (3) · University of Reading (3) · Anahuac University (2) · Slimbiotics GmbH (2) · The University of Texas Health Science Center at San Antonio (2) · Universidade Federal de Santa Catarina (2) · Universitas Sriwijaya (2) · University of Calgary (2) · Alexandria University (1) · Bogomolets National Medical University (1) · Celia Bañuls (1) · Chr Hansen - part of Novonesis (1)
United States (10) · United Kingdom (8) · Indonesia (5) · Brazil (4) · Mexico (4) · Canada (3) · China (3) · Italy (3) · Egypt (2) · Germany (2) · India (2) · South Africa (2) · Spain (2) · Thailand (2) · Australia (1)
Bruna Guida, MD (2) · George Macfarlane, PhD (2) · Nicolas Musi, MD. (2) · Amrita Vijay, PhD (1) · Andi Anggeraini (1) · Azita Hekmatdoost, MD, PhD (1) · Christiane Laue, Dr. med. (1) · Christine T Peterson, PhD (1) · Christopher D Byrne, MBBCh, PhD (1) · Cleber Kruel, Doctor (1) · Craig Mowatt (1) · Dalia Ahmed Nafea, M.D., Ph.D. (1) · Daniel Roth, MD, PhD (1) · Dr. Lee Le Ye, MD (1)
PMID 36126902, PMID 23957631, PMID 24401715, PMID 24743428, PMID 24929795, PMID 25909598, PMID 26602219, PMID 27057326, PMID 29787859, PMID 31987796, PMID 35845797, PMID 36585139, PMID 37293067, PMID 37474971, PMID 37870148, PMID 39179207, PMID 39289685, PMID 39821451, PMID 39915586, PMID 39992135, PMID 40032396, PMID 40434674, PMID 41094562, PMID 42026772, PMID 42066676, PMID 42141362
R01HD053719 (1), R01HD105492 (1)