8 completed, 3 recruiting, 2 unknown, 1 active not recruiting. 16 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 8, Recruiting 2, Unknown 2, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Terminated 1 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow Insomnia, Primary: new trials by email Literature Review of Insomnia, Primary trials Research Report on Insomnia, Primary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficiency of Intermittent Hypoxia Intervention in Primary Insomnia Intermittent Hypoxia, Sham Intermittent Hypoxia - Insomnia, Primary | Not applicable | Not yet recruiting | Capital Medical University | 30 | 2026-04-01 | 2026-02-06 |
| Comparative Efficacy of BRT and CBT-I for Insomnia Cognitive behavioral therapy for insomnia (CBT-I), Bedtime restriction (BRT) - Insomnia Disorders, Insomnia Disorder | Not applicable | Recruiting | Christoph Nissen | 160 | 2025-03-10 | 2025-02-17 |
| SHADES Mechanistic Trial Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I - Insomnia, Insomnia Chronic | Not applicable | Enrolling by invitation | Indiana University | 200 | 2024-04-25 | 2026-08-06 |
| Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Cognitive Behavioral Treatment for Insomnia (CBT-I), Trazodone, Placebo - Insomnia, Insomnia Chronic | Early Phase 1 | Recruiting | Milton S. Hershey Medical Center | 600 | 2024-03-20 | 2025-11-10 |
| Evaluating an Online Mindfulness-Based Intervention for Insomnia 'Mindful Living With Insomnia (MLWI)' Intervention via WeChat mini-program, 'Cognitive Behavioral Therapy for insomnia (CBT-I)'via WeChat mini-program - Insomnia, Primary | Not applicable | Unknown | Central South University | 1000 | 2022-01-01 | 2021-03-19 |
| Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep Active cTBS, Sham cTBS - Insomnia, Primary | Not applicable | Recruiting | University of Arizona | 20 | 2021-08-06 | 2022-08-17 |
| Effects of Zero-Time Exercise (ZTEx) on Inactive Adults With Insomnia Disorder Zero Time Exercise, Sleep hygiene education - Insomnia, Primary | Not applicable | Completed | The Hong Kong Polytechnic University | 140 | 2020-09-01 | 2023-06-12 |
| Exercise and Insomnia Study: The Effects of 1 Week of Exercise Training on Insomnia Severity Outdoor Walking, Quiet Rest - Insomnia Chronic, Insomnia, Primary | Not applicable | Completed | University of Pittsburgh | 24 | 2020-08-11 | 2021-01-14 |
| Effects of Messaging App Reminder on the Compliance of Zero-Time Exercise (ZTEx) Zero Time Exercise training + WhatsApp anti-inertia reminders, Zero Time Exercise training alone - Insomnia, Primary | Not applicable | Completed | The Hong Kong Polytechnic University | 68 | 2020-01-31 | 2023-09-26 |
| Effects of Insomnia Treatment on Metabolism in Patients With Depression Cognitive Behavioral Therapy for Insomnia (CBT-I) - Insomnia Chronic, Insomnia | Not applicable | Completed | University of Pennsylvania | 10 | 2018-12-20 | 2023-01-17 |
| Occupation-based Sleep Program for People With Insomnia Occupation-based sleep intervention program, Insomnia Education Program at Integrated Mental Health Clinic (IMHC) - Insomnia, Primary, Insomnia | Not applicable | Completed | The Hong Kong Polytechnic University | 42 | 2018-06-18 | 2021-07-09 |
| Sleep To Reduce Incident Depression Effectively digital Cognitive Behavioral Therapy for Insomnia, face-to-face Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education Control - Insomnia, Primary, Major Depressive Disorder | Not applicable | Completed | Henry Ford Health System | 1237 | 2018-03-09 | 2024-10-01 |
| Effects of Leader Sleep Improvement on Leadership Online Cognitive Behavioral Therapy for Insomnia (CBT-I) - Insomnia, Primary, Chronic Insomnia | Not applicable | Unknown | University of Washington | 400 | 2018-01-01 | 2017-10-26 |
| Effects of Zero-Time Exercise (ZTEx) on Inactive Adults With Insomnia Zero Time Exercise, Sleep hygiene education - Insomnia, Primary | Not applicable | Completed | The Hong Kong Polytechnic University | 37 | 2017-06-05 | 2017-10-20 |
| Therapist-Directed VS Online Therapy for Insomnia Co-Occuring With Sleep Apnea Online Cognitive Behavioral Therapy (OCBT), Therapist-directed Cognitive Behavioral Therapy (TCBT) - Insomnia, Primary, Sleep Apnea, Obstructive | Not applicable | Active not recruiting | National Jewish Health | 384 | 2017-04-15 | 2025-02-21 |
| Study of Low Field Magnetic Stimulation (LFMS) on Measures of Sleep LFMS - Active, LFMS - Sham - Insomnia, Primary | Not applicable | Terminated | Medical University of South Carolina | 12 | 2016-11-01 | 2020-02-13 |
| Sleep to Prevent Evolving Affecting Disorders dCBTI, Sleep Education - Insomnia, Primary, Depression | Not applicable | Completed | Henry Ford Health System | 1385 | 2016-03-08 | 2024-01-12 |
Sleep Initiation and Maintenance Disorders (17) · Sleep Wake Disorders (3) · Depression (2) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Depressive Disorder, Major (1) · Heart Diseases (1) · Hypertension (1) · Metabolic Diseases (1) · Parasomnias (1) · Primary Dysautonomias (1) · Rumination Syndrome (1) · Sleep Apnea, Obstructive (1) · Stroke (1)
Dyssomnias (17) · Mental Disorders (17) · Nervous System Diseases (17) · Sleep Disorders, Intrinsic (17) · Sleep Wake Disorders (14) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Behavior (2) · Behavioral Symptoms (2) · Vascular Diseases (2) · Apnea (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Autonomic Nervous System Diseases (1)
Cognitive Behavioral Therapy (3) · Hygiene (1) · Trazodone (1)
The Hong Kong Polytechnic University (4) · Henry Ford Health System (2) · Capital Medical University (1) · Central South University (1) · Christoph Nissen (1) · Indiana University (1) · Medical University of South Carolina (1) · Milton S. Hershey Medical Center (1) · National Jewish Health (1) · University of Arizona (1) · University of Pennsylvania (1) · University of Pittsburgh (1) · University of Washington (1)
United States (9) · Hong Kong (4) · Canada (1) · Switzerland (1)
WF Yeung (2) · Alexandros Vgontzas, MD (1) · Andrew Kubala, MS (1) · Andrew MH Siu, PhD (1) · Chen Pan, Dr (1) · Christopher Drake, PhD (1) · Christopher L Drake, PhD (1) · Jesse C Stewart, Ph.D. (1) · Thomas Uhde, MD (1) · William D Killgore, PhD (1) · Yu Tse Heng (1)
PMID 30312957, PMID 31535688, PMID 33249492, PMID 34788453, PMID 35168972, PMID 35257648, PMID 36153634, PMID 36457045, PMID 38277210, PMID 39999728, PMID 41424521, PMID 41825236
1UG3HL161342-01A1 (1), R01HL165115 (1)