18 completed, 3 active not recruiting, 2 not yet recruiting, 1 recruiting. 22 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 17, Active not recruiting 3, Not yet recruiting 1, Recruiting 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Impacted Mandibular Third Molar: new trials by email Literature Review of Impacted Mandibular Third Molar trials Research Report on Impacted Mandibular Third Molar
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Electrocautery and Scalpel Blade Incisions of Impacted Mandibular Third Molars scalpel blade incision, electrocautery incision - Impacted Mandibular Third Molar | Not applicable | Not yet recruiting | Riphah International University | 78 | 2026-08-01 | 2026-07-23 |
| The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery Conventional Suturing, Sutureless Technique, Surgical Drain - Impacted Mandibular Third Molar, Postoperative Morbidity | Not applicable | Recruiting | Recep Tayyip Erdogan University | 148 | 2026-05-08 | 2026-06-09 |
| "Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery" Dexamethasone, No intervention - Impacted Mandibular Third Molar, Postoperative Pain | Phase 4 | Not yet recruiting | Hayat Abad Medical Complex, Peshawar | 268 | 2026-05-01 | 2026-05-01 |
| Preoperative Versus Postoperative Amoxicillin in Impacted Third Molar Surgery Amoxicillin - Impacted Mandibular Third Molar, Impacted Mandibular Third Molar Extraction | Completed | Recep Tayyip Erdogan University | 52 | 2026-04-10 | 2026-10-05 | |
| Effect of Preoperative Long-Acting Corticosteroids on Pain, Swelling, and Trismus After Impacted Lower Third Molar Surgery Dexamethasone 8 mg IM, Normal Saline IM - Impacted Mandibular Third Molar, Postoperative Pain | Not applicable | Active not recruiting | Al Salam University | 60 | 2026-01-04 | 2026-03-05 |
| Effect of Platelet-Rich Fibrin on Postoperative Pain, Trismus, and Edema After Mandibular Third Molar Surgery Platelet-rich fibrin (PRF), Sterile Absorbable Gelatin Sponge - Impacted Mandibular Third Molar, Postoperative Pain | Not applicable | Completed | PAEC General Hospital, Islamabad | 134 | 2025-12-09 | 2026-06-29 |
| Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery Dexamethasone - Impacted Mandibular Third Molar, Postoperative Pain | Not applicable | Active not recruiting | 28 Military Dental Centre Lahore | 70 | 2025-12-01 | 2026-04-20 |
| Soft Tissue Healing and Bacterial Load With Triclosan-Coated Sutures After Impacted Mandibular Third Molar Surgery Triclosan-coated Polyglactin 910 suture, Non-coated polyglactin 910 suture - Impacted Mandibular Third Molar, Postoperative Wound Healing | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 15 | 2025-10-07 | 2026-09-01 |
| Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery cyanoacrylate tissue adhesive, Silk Sutures - Impacted Mandibular Third Molar | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 23 | 2025-10-02 | 2026-09-02 |
| Effects of Virtual Reality Content on Anxiety During Third Molar Surgery Nature-Based Virtual Reality, Art-Gallery Virtual Reality - Dental Anxiety, Impacted Mandibular Third Molar | Not applicable | Completed | Recep Tayyip Erdogan University | 75 | 2025-10-01 | 2026-09-16 |
| The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus. Kloroben topical spray, Klorhex Plus topical spray - Impacted Mandibular Third Molar | Not applicable | Completed | Marmara University | 40 | 2025-04-20 | 2026-03-25 |
| Adjacent Molar Outcomes After Third Molar Surgery With PRF or Collagen Sponge Platelet-rich fibrin (PRF), Absorbable Collagen Sponge - Impacted Mandibular Third Molar, Wound Healing | Not applicable | Completed | Gazi University | 29 | 2025-02-28 | 2026-04-15 |
| Single-Session Extraoral PBM After Third Molar Extraction Dual-wavelength GaAlAs laser (650+904 nm) - Impacted Mandibular Third Molar, Edema | Not applicable | Completed | Konya Necmettin Erbakan Üniversitesi | 70 | 2025-02-15 | 2026-06-09 |
| Efficacy of Er:YAG Laser in Removing Impacted Mandibular Third Molars Er:YAG laser, Conventional Rotary Instruments Surgery - Impacted Mandibular Third Molar | Not applicable | Completed | Alexandria University | 24 | 2024-09-25 | 2025-12-29 |
| Ultrasonic vs Rotary Instruments in Impacted Mandibular Third Molar Surgery: Clinical and Salivary CRP Outcomes Ultrasonic Device (Piezosurgery), Conventional rotary instruments - Impacted Mandibular Third Molar, Pain | Not applicable | Completed | Le Huynh Thien An | 22 | 2024-09-01 | 2025-10-01 |
| The Effect of Topical Application of Hyaluronic Acid and Melatonin Mixture Following Surgical Extraction of Impacted Mandibular Third Molars . Hyaluronic acid and Melatonin mixture, Gel foam - Impacted Mandibular Third Molar | Not applicable | Completed | Kafrelsheikh University | 40 | 2024-07-22 | 2026-09-08 |
| Does Vitamin C Improve Postoperative Healing Vitamin C, Placebo - Impacted Mandibular Third Molar | Not applicable | Completed | Hacettepe University | 56 | 2024-06-01 | 2025-06-10 |
| Salivary α-Amylase as a Non-Invasive Biomarker of PRF-Enhanced Wound Healing After Third Molar Surgery PRF group - Platelet-Rich Fibrin (PRF), Impacted Mandibular Third Molar | Not applicable | Completed | Hasanuddin University | 28 | 2024-05-12 | 2026-05-20 |
| Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF. Impacted third molar extraction, Advanced Platelet-Rich Fibrin (A-PRF), Mandibular dentigerous cyst enucleation - Impact Molar, Mandible Cyst | Not applicable | Active not recruiting | Jagiellonian University | 35 | 2024-04-04 | 2026-06-23 |
| Audiovisual vs Verbal Information in Third Molar Surgery Audiovisual Information, Verbal Information - Dental Anxiety, Impacted Mandibular Third Molar | Not applicable | Completed | Gazi University | 73 | 2024-03-01 | 2026-04-14 |
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Pain, Postoperative (10) · Trismus (9) · Edema (4) · Pain (3) · Tooth, Impacted (2) · Alveolar Bone Loss (1) · Dentigerous Cyst (1) · Inflammation (1) · Smoking (1)
Neurologic Manifestations (13) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Pathologic Processes (11) · Pain (10) · Postoperative Complications (10) · Nervous System Diseases (9) · Neuromuscular Manifestations (9) · Spasm (9) · Stomatognathic Diseases (4) · Musculoskeletal Diseases (2) · Tooth Diseases (2) · Behavior (1) · Bone Cysts (1) · Bone Diseases (1)
Dexamethasone (3) · Amoxicillin (1) · Ascorbic Acid (1) · Fibrin Foam (1) · Hyaluronic Acid (1) · Hypochlorous Acid (1) · Lasers, Solid-State (1) · Low-Level Light Therapy (1) · Piezosurgery (1) · Sutureless Surgical Procedures (1) · Vaginal Creams, Foams, and Jellies (1)
Recep Tayyip Erdogan University (3) · Gazi University (2) · University of Medicine and Pharmacy at Ho Chi Minh City (2) · 28 Military Dental Centre Lahore (1) · Al Salam University (1) · Alexandria University (1) · Ankara University (1) · Cumhuriyet University (1) · Hacettepe University (1) · Hasanuddin University (1) · Hayat Abad Medical Complex, Peshawar (1) · Jagiellonian University (1) · Kafrelsheikh University (1) · Konya Necmettin Erbakan Üniversitesi (1) · Le Huynh Thien An (1)
Turkey (Türkiye) (11) · Egypt (3) · Pakistan (3) · Vietnam (3) · Poland (2) · Indonesia (1)
Ahmed K Fawzi, BDS, MSc, PhD (1) · Karim Elhaw, MSc (Oral Laser Applications) (1) · Mariusz Szuta, MD, PhD (1) · Mehmet Emre Yurttutan, PhD, DDS (1) · Muhammet Caner Dere, DDS (1) · Nur Mollaoglu, OMFS PROFESSOR (1) · Omaima M Sakr, BDS, MSc, PhD (1) · Son Hoang Le (1) · Tomasz Kaczmarzyk (1) · Uzair Luqman, BDS/FCPS (1)
PMID 15510357, PMID 18795563, PMID 22696337, PMID 24324311, PMID 27475700, PMID 29675759, PMID 30501926, PMID 32183831, PMID 32919832, PMID 34447785, PMID 34713808, PMID 35027927, PMID 37177802, PMID 38267703, PMID 38907642, PMID 39117914, PMID 39467892, PMID 40181005, PMID 42243813, PMID 8233418