8 completed, 4 terminated, 3 unknown, 1 withdrawn. 16 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 8, Terminated 4, Unknown 3, Withdrawn 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
Follow Ileus: new trials by email Literature Review of Ileus trials Research Report on Ileus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy Bupivacaine, Morphine, Lidocaine - Cancer Debulking, Enlarged Uterus | Phase 2 | Terminated | Washington University School of Medicine | 110 | 2022-01-18 | 2025-07-31 |
| Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial Rifaximin oral tablet, Placebo oral tablet - Chronic Intestinal Pseudo-obstruction | Phase 2 | Unknown | Yokohama City University | 12 | 2019-12-25 | 2021-06-21 |
| A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection LB1148, Placebo - Ileus, Post-Operative Adhesions | Phase 2 | Completed | Palisade Bio | 112 | 2019-10-01 | 2024-06-21 |
| Study to Evaluate LB1148 for Return of Gastrointestinal Function, Decrease Post-Operative Ileus LB1148, Placebo - Ileus | Phase 2 | Completed | Newsoara Biopharma Co., Ltd. | 131 | 2019-07-09 | 2021-09-27 |
| Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention Methylnaltrexone, Placebo - Postoperative Ileus | Phase 2 | Completed | Ohio State University | 82 | 2019-02-21 | 2021-10-27 |
| The Effect of Foeniculum Vulgare Ironing on Gastrointestinal Recovery After Colorectal Resection Foeniculum Vulgare Seed Ironing - Colorectal Surgery, Foeniculum | Phase 2 | Completed | West China Hospital | 300 | 2018-10-20 | 2019-09-17 |
| Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC Alvimopan, Placebo - Ileus | Phase 2 | Terminated | University of California, San Diego | 84 | 2018-03-08 | 2021-08-18 |
| Stimulation of the Efferent Loop Before Loop Ileostomy Closure efferent limb stimulation - Ileostomy - Stoma, Ileostomy; Complications | Phase 2 | Unknown | Hospital de Basurto | 140 | 2014-11-20 | 2018-02-07 |
| Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After Pancreaticoduodenectomy Oral/enteral TJ-100 solution, Oral/enteral placebo solution - Paralytic Ileus | Phase 2 | Unknown | Wakayama Medical University | 220 | 2012-08-01 | 2013-12-18 |
| Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer Gum chewing - Paralytic Ileus | Phase 2 / Phase 3 | Withdrawn | Chiang Mai University | 2011-07-01 | 2016-08-30 | |
| Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery. Inhaled Carbon Monoxide, Synthetic Air - Ileus | Phase 2 | Terminated | Queen's University | 3 | 2011-04-01 | 2015-11-17 |
| The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section Gum chewing - Paralytic Ileus | Phase 2 / Phase 3 | Completed | Chiang Mai University | 100 | 2010-05-01 | 2011-06-28 |
| Efficacy, Safety, and Tolerability of JNJ-27018966 (Eluxadoline) in the Treatment of Irritable Bowel Syndrome With Diarrhea Eluxadoline, Placebo - Irritable Bowel Syndrome | Phase 2 | Completed | Furiex Pharmaceuticals, Inc | 807 | 2010-04-28 | 2019-10-22 |
| Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus Ipamorelin, placebo - Ileus | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 117 | 2008-04-01 | 2017-04-14 |
| A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia Imipenem/cilastatin, Doripenem - Pneumonia, Ventilator-Associated, Pneumonia, Bacterial | Phase 2 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 146 | 2007-10-01 | 2019-03-19 |
| Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus) Acupuncture - Ileus, Neoplasms | Phase 2 | Terminated | National Center for Complementary and Integrative Health (NCCIH) | 100 | 2003-09-01 | 2017-03-28 |
Intestinal Pseudo-Obstruction (4) · Abdominal Abscess (1) · Bacterial Infections (1) · Colonic Diseases (1) · Colonic Diseases, Functional (1) · Colonic Pseudo-Obstruction (1) · Diarrhea (1) · Digestive System Diseases (1) · Fever (1) · Gastrointestinal Diseases (1) · Intestinal Diseases (1) · Irritable Bowel Syndrome (1) · Leiomyoma (1) · Neoplasms (1)
Intestinal Obstruction (16) · Digestive System Diseases (15) · Gastrointestinal Diseases (15) · Intestinal Diseases (15) · Neoplasms (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Abdominal Neoplasms (1) · Abscess (1) · Bacterial Infections and Mycoses (1) · Body Temperature Changes (1) · Connective Tissue Diseases (1) · Cross Infection (1) · Digestive System Neoplasms (1)
Chewing Gum (2) · Acupuncture Therapy (1) · Bupivacaine (1) · Cilastatin, Imipenem Drug Combination (1) · Doripenem (1) · Exercise (1) · Lidocaine (1) · Morphine (1) · Rifaximin (1) · alvimopan (1) · apoptosis-induced regulator protein (1) · eluxadoline (1) · ipamorelin (1) · methylnaltrexone (1)
Chiang Mai University (2) · Furiex Pharmaceuticals, Inc (1) · Helsinn Therapeutics (U.S.), Inc (1) · Hospital de Basurto (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · Newsoara Biopharma Co., Ltd. (1) · Ohio State University (1) · Palisade Bio (1) · Queen's University (1) · University of California, San Diego (1) · Wakayama Medical University (1) · Washington University School of Medicine (1) · West China Hospital (1) · Yokohama City University (1)
United States (7) · China (2) · Japan (2) · Thailand (2) · Canada (1) · Spain (1)
Kittipat Charoenkwan, MD (2) · Hiroki Yamaue, M.D., Ph.D. (1) · Joel M Baumgartner, MD, MAS (1) · Joseph S Chiang, MD (1) · Mitch Jones, MD (1) · Paul J Belliveau, MD (1) · Premal H Thaker, M.D., MS (1) · Suzan Allen (1) · Ziqiang Wang, MD (1)
PMID 15351109, PMID 16850151, PMID 19610681, PMID 20334152, PMID 23583433, PMID 24813429, PMID 25331030, PMID 25819420, PMID 26747224, PMID 26867333, PMID 28167156, PMID 29067571, PMID 29621360, PMID 30333892, PMID 34798295, PMID 36102565