17 completed, 5 terminated, 2 recruiting, 1 withdrawn. 11 Phase 3, 5 Phase 2, 5 Phase 4, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 8, Recruiting 2, Terminated 1 |
| Phase 2 | 5 | Completed 3, Terminated 2 |
| Phase 4 | 5 | Completed 3, Terminated 1, Withdrawn 1 |
| Not applicable | 3 | Completed 2, Terminated 1 |
Follow alvimopan: new trials by email Literature Review of alvimopan trials Research Report on alvimopan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Surgical Techniques During Cystectomy Stent placement, Alvimopan - Bladder Cancer | Phase 3 | Recruiting | Memorial Sloan Kettering Cancer Center | 530 | 2024-11-21 | 2026-09-22 |
| Alvimopan as a Rescue Treatment of Postoperative Ileus Alvimopan - Ileus, Gastrointestinal Dysfunction | Phase 4 | Completed | Scott Steele | 65 | 2020-08-01 | 2025-08-20 |
| Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol Alvimopan, Placebo - Bladder Cancer | Phase 3 | Recruiting | Brigham and Women's Hospital | 136 | 2018-10-01 | 2023-09-28 |
| Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC Alvimopan, Placebo - Ileus | Phase 2 | Terminated | University of California, San Diego | 84 | 2018-03-08 | 2021-08-18 |
| Alvimopan Use in Polytraumatized Patients Alvimopan, Placebo - Post Operative Ileus | Phase 4 | Terminated | University of Puerto Rico | 3 | 2017-09-01 | 2020-02-05 |
| Ketamine in Colorectal Surgery Placebo, Ketamine, Acetaminophen - Acute Pain, Pain, Postoperative | Phase 4 | Withdrawn | Medical College of Wisconsin | 2016-07-01 | 2017-10-26 | |
| Trial of Alvimopan in Major Spine Surgery Alvimopan, Placebo - Constipation | Phase 4 | Completed | University of Virginia | 49 | 2016-06-01 | 2020-12-01 |
| Alvimopan as Rescue in Post op Ileus Alvimopan, Control Group - Colorectal Surgery, Ileus | Phase 3 | Terminated | Sharon Stein | 14 | 2015-12-02 | 2022-11-18 |
| Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia Repair Alvimopan, Placebo - Ventral Hernia | Not applicable | Terminated | Medical College of Wisconsin | 10 | 2015-07-01 | 2019-11-14 |
| Alvimopan and Ileus in PSF Alvimopan, Placebo - Ileus, Spinal Fusion | Not applicable | Completed | Washington University School of Medicine | 31 | 2014-08-01 | 2019-05-17 |
| Accelerating Gastrointestinal Recovery Alvimopan, Placebo - Ovarian Cancer, Fallopian Tube Cancer | Phase 3 | Completed | Jamie N. Bakkum-Gamez | 146 | 2013-01-01 | 2016-10-24 |
| Entereg Laparoscopic Colon Resection Study Entereg, placebo - Laparoscopic Colonic Resection | Phase 2 | Completed | Hartford Hospital | 135 | 2010-11-01 | 2015-08-26 |
| Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use Alvimopam, 300 mg Polyethylene - Ileus | Not applicable | Completed | Intermountain Health Care, Inc. | 274 | 2010-05-01 | 2014-09-04 |
| Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database Alvimopan - Ileus | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 7050 | 2010-04-01 | 2015-08-07 | |
| A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy Alvimopan, Placebo - Postoperative Ileus | Phase 4 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 280 | 2009-03-01 | 2016-01-08 |
| Clinical Evaluation Of Alvimopan (SB767905) On Constipation And Related Symptoms Associated With Opioid alvimopan, Placebo, Alvimopan 0.5 mg/day - Cancer, Constipation | Phase 2 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 21 | 2006-04-01 | 2015-09-02 |
| Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain Alvimopan, Placebo - Bowel Dysfunction, Constipation | Phase 3 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 805 | 2005-08-01 | 2017-08-30 |
| Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain Placebo, Alvimopan, Alviompan - Bowel Dysfunction, Constipation | Phase 3 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 485 | 2005-08-01 | 2015-09-02 |
| Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain alvimopan, Placebo - Bowel Dysfunction, Constipation | Phase 3 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 518 | 2005-08-01 | 2015-09-02 |
| Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects alvimopan, placebo - Cancer, Bowel Dysfunction | Phase 2 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 67 | 2004-09-01 | 2015-09-02 |
Showing 20 of 25. Sign in to see all of them.
Ileus (11) · Constipation (7) · Intestinal Diseases (5) · Pain (4) · Neoplasms (3) · Urinary Bladder Neoplasms (2) · Acute Pain (1) · Cancer Pain (1) · Fallopian Tube Neoplasms (1) · Hernia, Ventral (1) · Opioid-Induced Constipation (1) · Ovarian Neoplasms (1) · Pain, Postoperative (1) · Peritoneal Neoplasms (1)
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (12) · Medical College of Wisconsin (2) · Brigham and Women's Hospital (1) · Hartford Hospital (1) · Intermountain Health Care, Inc. (1) · Jamie N. Bakkum-Gamez (1) · Memorial Sloan Kettering Cancer Center (1) · Scott Steele (1) · Sharon Stein (1) · University of California, San Diego (1) · University of Puerto Rico (1) · University of Virginia (1) · Washington University School of Medicine (1)
United States (23) · Canada (5) · Finland (4) · New Zealand (4) · Poland (4) · Spain (4) · United Kingdom (4) · Australia (3) · France (3) · Hong Kong (3) · Hungary (3) · Netherlands (3) · Austria (2) · Denmark (2) · Germany (2)
Lee Techner, DPM (2) · Alvin Goh, MD (1) · Bhiken Naik, MBBCh (1) · Bob Moesinger, MD (1) · Carrie Y Peterson, MD (1) · Conor Delaney, MD, PhD (1) · Jamie Bakkum-Gamez, MD (1) · Joel M Baumgartner, MD, MAS (1) · Mark A Preston, MD (1) · Matthew I Goldblatt, MD (1) · Matthew Peters, RN (1) · Michael P Kelly, MD (1) · Sharon Stein, MD (1)
PMID 20526599, PMID 15383800, PMID 15906123, PMID 16333556, PMID 19015469, PMID 21292168, PMID 21292169, PMID 22388106, PMID 24630419, PMID 36102565