11 completed, 1 terminated. 8 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 7, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Netupitant and Palonosetron Hydrochloride in Preventing Chemotherapy Induced Nausea and Vomiting in Patients With Cancer Undergoing BEAM Conditioning Regimen Before Stem Cell Transplant Netupitant, Palonosetron Hydrochloride, Questionnaire Administration - Malignant Neoplasm | Phase 2 | Completed | OHSU Knight Cancer Institute | 43 | 2017-04-27 | 2021-07-12 |
| Clinical Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed With Mycosis Fungoides Cutaneous T-cell Lymphoma Valchlor - Mycosis Fungoides | Completed | Helsinn Therapeutics (U.S.), Inc | 300 | 2014-11-12 | 2020-03-04 | |
| The Role of Ghrelin in Cancer Cachexia Anamorelin HCl, Placebo - Cancer Cachexia | Phase 2 | Terminated | VA Office of Research and Development | 10 | 2012-06-01 | 2018-07-17 |
| Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2) Anamorelin HCl, Placebo - Cachexia, Non-Small Cell Lung Cancer | Phase 3 | Completed | Helsinn Therapeutics (U.S.), Inc | 495 | 2011-07-01 | 2017-10-27 |
| Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3) Anamorelin HCl, Placebo - Cachexia, Non-Small Cell Lung Cancer | Phase 3 | Completed | Helsinn Therapeutics (U.S.), Inc | 513 | 2011-07-01 | 2017-09-14 |
| Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) Anamorelin HCl, Placebo - Cachexia, Non-Small Cell Lung Cancer | Phase 3 | Completed | Helsinn Therapeutics (U.S.), Inc | 484 | 2011-07-01 | 2017-10-27 |
| Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function Saline Solution for Injection, Ipamorelin - Gastrointestinal Dysmotility | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 320 | 2011-04-01 | 2017-04-13 |
| Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus Ipamorelin, placebo - Ileus | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 117 | 2008-04-01 | 2017-04-14 |
| Dose Range Study of Anamorelin in Patients With Non-small Cell Lung Cancer anamorelin HCl, placebo - Carcinoma, Non-Small-Cell Lung | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 228 | 2008-03-01 | 2017-04-14 |
| Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia RC-1291, placebo - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 51 | 2006-09-01 | 2013-09-02 |
| Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia. RC-1291 HCl, Placebo - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 2005-11-01 | 2013-09-02 | |
| Safety and Efficacy of RC-1291 HCl in Patients With Cancer Related Anorexia and Weight Loss RC-1291 HCl - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 80 | 2005-06-01 | 2013-09-02 |
Cachexia (5) · Carcinoma, Non-Small-Cell Lung (4) · Neoplasms (2) · Anorexia (1) · Ileus (1) · Lymphoma, T-Cell, Cutaneous (1) · Mycosis Fungoides (1)
ipamorelin (2) · Amines (1) · Injections (1) · Palonosetron (1) · RC-1291 (1) · Saline Solution (1) · netupitant (1)
United States (12) · Hungary (3) · Poland (3) · Russia (3) · Australia (2) · Belarus (2) · Belgium (2) · Canada (2) · Czechia (2) · France (2) · Germany (2) · Israel (2) · Italy (2) · Serbia (2) · Slovenia (2)
William Polvino, MD (3) · Bill Bailey (1) · Jennifer Temel, MD (1) · Jose M. Garcia, MD PhD (1) · Joseph Bubalo (1) · Suzan Allen (1)
PMID 28472437, PMID 25524795, PMID 26906526, PMID 39992021, PMID 25331030, PMID 25351456