26 completed, 6 unknown, 5 terminated, 1 recruiting. 38 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 38 | Completed 26, Unknown 6, Terminated 5, Recruiting 1 |
Follow Hypopituitarism: new trials by email Literature Review of Hypopituitarism trials Research Report on Hypopituitarism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of GH and Lirglutide on AgRP growth hormone and lirglutide, growth hormone, liraglutide - Healthy, Growth Hormone Deficiency | Phase 4 | Recruiting | Columbia University | 40 | 2023-05-01 | 2026-03-04 |
| Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium Intravenous Infusion of Diclofenac Sodium, Intravenous Infusion of Placebo - Hypopituitarism | Phase 4 | Completed | A.O.U. Città della Salute e della Scienza | 12 | 2021-10-01 | 2022-01-12 |
| Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes Intranasal glugagon, Intranasal placebo - Hypopituitarism | Phase 4 | Completed | A.O.U. Città della Salute e della Scienza | 10 | 2021-10-01 | 2022-01-25 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study) Experimental: GLP1-RA (exenatide) administration, Control: Placebo administration - Hypopituitarism, Central Diabetes Insipidus | Phase 4 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 42 | 2021-09-13 | 2026-01-20 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study) Experimental: CRH administration, Control: Placebo administration - Hypopituitarism, Central Diabetes Insipidus | Phase 4 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 52 | 2021-07-06 | 2024-04-03 |
| Body Composition and Adipose Tissue in HIV Tesamorelin - HIV Lipodystrophy Syndrome, Growth Hormone Deficiency | Phase 4 | Terminated | Columbia University | 6 | 2018-02-07 | 2026-05-19 |
| Optimising Steroid Replacement in Patients With Adrenal Insufficiency Modified release hydrocortisone - Adrenal Insufficiency | Phase 4 | Unknown | The Adelaide and Meath Hospital, incorporating The National Children's Hospital | 60 | 2017-09-05 | 2017-09-14 |
| Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj. Somatropin - Short Stature, Idiopathic, Infant, Small for Gestational Age | Phase 4 | Completed | LG Life Sciences | 116 | 2016-08-11 | 2019-01-03 |
| A Post-Marketing Study of the Immunogenicity of Somatropin (Ribosomal Deoxyribo Nucleic Acid [rDNA] Origin) Injection (Nutropin AQ®) in Children With Growth Hormone Deficiency Somatropin - Growth Hormone Deficiency | Phase 4 | Completed | Genentech, Inc. | 82 | 2015-03-31 | 2019-01-08 |
| Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency PEG-somatropin - Growth Hormone Deficiency | Phase 4 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 600 | 2015-01-01 | 2017-06-16 |
| Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency PEG-somatropin - Growth Hormone Deficiency | Phase 4 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 900 | 2015-01-01 | 2017-08-15 |
| Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children (Clinical Trial I) PEG-somatropin - Growth Hormone Deficiency | Phase 4 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 600 | 2014-12-01 | 2017-06-16 |
| Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children PEG-somatropin - Dwarfism, Pituitary | Phase 4 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 900 | 2014-11-01 | 2014-12-11 |
| Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency PEG-somatropin - Growth Hormone Deficiency | Phase 4 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 900 | 2014-11-01 | 2017-06-14 |
| An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD) Saizen® solution for injection (referred as Saizen®) - Adult Growth Hormone Deficiency | Phase 4 | Completed | Merck KGaA, Darmstadt, Germany | 78 | 2013-06-01 | 2017-12-02 |
| GH and Cardiovascular Risk Factors Change in daily dosage of Growth Hormone - Growth Hormone Deficiency, Cardiovascular Diseases | Phase 4 | Completed | Amsterdam UMC, location VUmc | 32 | 2013-05-01 | 2014-05-07 |
| First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study Blood sampling - Idiopathic Growth Hormone Deficiency, Turner Syndrome | Phase 4 | Completed | Merck KGaA, Darmstadt, Germany | 458 | 2011-09-01 | 2014-01-16 |
| Safety and Efficacy of SR-hGH (Sustained-release Human Growth Hormone, Declage Inj.) sustained-release recombinant human GH (SR-rhGH) - Growth Hormone Deficiency | Phase 4 | Completed | LG Life Sciences | 132 | 2009-12-01 | 2012-10-05 |
| Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method T-jet® containing TevTropin®, TevTropin® needle-syringe injection method - Growth Hormone Deficiency | Phase 4 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 52 | 2009-09-01 | 2011-07-25 |
| Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome? Growth hormone (Genotonorm® or Omnitrope®), DEXA, blood tests, H.G.P.O, osseous age., biopsy - Prader-Willi Syndrome, Growth Hormone Deficiency | Phase 4 | Completed | University Hospital, Toulouse | 111 | 2009-01-01 | 2021-09-24 |
Showing 20 of 38. Sign in to see all of them.
Dwarfism, Pituitary (30) · Dwarfism (4) · Combined Pituitary Hormone Deficiency (3) · Turner Syndrome (3) · Adrenal Insufficiency (2) · Brain Injuries (2) · Brain Injuries, Traumatic (2) · Diabetes Insipidus, Neurogenic (2) · Hypothalamic Diseases (2) · Kidney Failure, Chronic (2) · Mental Disorders (2) · Pituitary Diseases (2) · Social Isolation (2) · Cardiovascular Diseases (1)
Brain Diseases (38) · Central Nervous System Diseases (38) · Endocrine System Diseases (38) · Nervous System Diseases (38) · Hypothalamic Diseases (36) · Pituitary Diseases (36) · Bone Diseases (30) · Bone Diseases, Developmental (30) · Bone Diseases, Endocrine (30) · Musculoskeletal Diseases (30) · Dwarfism (26) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (8) · Urogenital Diseases (7)
Human Growth Hormone (14) · Growth Hormone (9) · Blood Specimen Collection (3) · Absorptiometry, Photon (1) · Arginine (1) · Biopsy (1) · Cosyntropin (1) · Exenatide (1) · Growth Hormone-Releasing Hormone (1) · Hematologic Tests (1) · Injections (1) · Liraglutide (1) · Organization and Administration (1) · Referral and Consultation (1) · Sodium Chloride (1)
Changchun GeneScience Pharmaceutical Co., Ltd. (5) · Merck KGaA, Darmstadt, Germany (5) · Columbia University (3) · Pfizer (3) · A.O.U. Città della Salute e della Scienza (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · LG Life Sciences (2) · Novo Nordisk A/S (2) · Amsterdam UMC, location VUmc (1) · Cardiff University (1) · Charite University, Berlin, Germany (1) · Children's Hospital Los Angeles (1) · EMD Serono (1) · Eli Lilly and Company (1) · Genentech, Inc. (1)
United States (11) · France (7) · Germany (6) · Italy (6) · United Kingdom (6) · China (5) · Spain (5) · Sweden (4) · Argentina (2) · Australia (2) · Canada (2) · Netherlands (2) · Austria (1) · Czechia (1) · Greece (1)
Anna Aulinas, MD PhD (2) · Aled Rees, MB BCh, PhD (1) · Amira Y Al-Uzri, M.D. (1) · Ayman M Arafat, Dr.med. (1) · Chunxiu Gong (1) · Feihong Luo, Doctor (1) · Gilles Della Corte (1) · John C Ausiello, MD (1) · Junfen Fu, Ph.D (1) · Junfen Fu, PhD (1)
PMID 17711927, PMID 20372873, PMID 23567489, PMID 23761380, PMID 24013497, PMID 24406482, PMID 24916642, PMID 26340968, PMID 29618660, PMID 29980224, PMID 31908426, PMID 33633687, PMID 34040195, PMID 34045667, PMID 34899612, PMID 35945517, PMID 36034802, PMID 37339332, PMID 38561465, PMID 39824923
R01DK110771 (1)