13 completed, 10 recruiting, 2 unknown, 1 not yet recruiting. 12 Not applicable, 5 Phase 2, 2 Early Phase 1, 2 Phase 4, 1 Phase 1.
Follow Diabetes Insipidus, Neurogenic: new trials by email Literature Review of Diabetes Insipidus, Neurogenic trials Research Report on Diabetes Insipidus, Neurogenic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease Norethindrone Acetate-Ethinyl Estradiol - Arginine Vasopressin Deficiency, Oxytocin Deficiency | Early Phase 1 | Recruiting | Massachusetts General Hospital | 20 | 2026-08-17 | 2026-08-21 |
| Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome Mannitol, Hypertonic Saline - Arginine Vasopressin Deficiency, Primary Polydipsia | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 144 | 2026-06-16 | 2026-06-18 |
| Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency estradiol valerate, esthinylestradiol - AVP Deficiency, Diabetes Insipidus | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 28 | 2026-01-09 | 2026-08-11 |
| Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology sonic augmentation technology - Sonic Augmentation Technology | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 22 | 2026-01-09 | 2026-02-13 |
| Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency Intranasal Oxytocin (IN-OXT), Placebo - Vasopressin Deficiency | Phase 1 | Recruiting | Elizabeth Austen Lawson | 40 | 2025-09-10 | 2026-07-23 |
| Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls Oxytocin nasal spray, Placebo - Arginine Vasopressin Deficiency, Central Diabetes Insipidus | Phase 2 | Recruiting | University Hospital, Basel, Switzerland | 42 | 2025-07-01 | 2025-10-03 |
| Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls Oxytocin nasal spray, Placebo - Arginine Vasopressin Deficiency, Diabetes Insipidus | Phase 2 | Recruiting | University Hospital, Basel, Switzerland | 42 | 2025-05-16 | 2025-05-23 |
| Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children Measure of Basal Copeptin level, Measure of arginine-stimulated copeptin, IRM - Primary Polydipsia, Central Diabetes Insipidus | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 155 | 2025-03-01 | 2025-02-13 |
| Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls MDMA, Placebo - Central Diabetes Insipidus | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 24 | 2025-01-27 | 2025-02-19 |
| The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU serum copeptin levels - Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels | Recruiting | Children's Hospital of Fudan University | 100 | 2024-11-22 | 2026-02-17 | |
| Identifying Oxytocin Deficiency in Adults With Pituitary Disease Norethindrone Acetate-Ethinyl Estradiol - Arginine Vasopressin Deficiency, Oxytocin Deficiency | Early Phase 1 | Completed | Elizabeth Austen Lawson | 28 | 2024-11-13 | 2026-05-13 |
| Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study) Mannitol Infusion (blinded), Placebo Infusion (blinded), Mannitol Infusion (open label) - Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency | Not applicable | Completed | University Hospital, Basel, Switzerland | 42 | 2024-09-10 | 2025-12-15 |
| Registry of Patients in Shock Treated With Vasopressin Vasopressin - Vasopressin Causing Adverse Effects in Therapeutic Use, Shock | Unknown | Hospital Universitario 12 de Octubre | 500 | 2024-07-09 | 2024-07-15 | |
| Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus Intranasal OXT, Placebo nasal spray - Central Diabetes Insipidus (cDI) | Phase 2 | Recruiting | University Hospital, Basel, Switzerland | 112 | 2024-01-08 | 2026-05-06 |
| Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome Urea, Placebo - Arginine Vasopressin Deficiency, Primary Polydipsia | Not applicable | Completed | University Hospital, Basel, Switzerland | 48 | 2023-06-02 | 2024-07-09 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study) Melatonin - Oxytocin Deficiency, Hypopituitarism | Not applicable | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 40 | 2022-04-01 | 2024-04-09 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study) Experimental: GLP1-RA (exenatide) administration, Control: Placebo administration - Hypopituitarism, Central Diabetes Insipidus | Phase 4 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 42 | 2021-09-13 | 2026-01-20 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study) Experimental: CRH administration, Control: Placebo administration - Hypopituitarism, Central Diabetes Insipidus | Phase 4 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 52 | 2021-07-06 | 2024-04-03 |
| Fecal Microbiota Transplantation for Early Clostridioides Difficile Infection Fecal microbiota transplantion (FMT), Placebo - Clostridium Difficile Infection, Clostridioides Difficile Infection | Not applicable | Completed | Christian Lodberg Hvas | 42 | 2021-06-02 | 2026-10-16 |
| Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls study intervention: 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), Control intervention: Placebo - Diabetes Insipidus | Not applicable | Completed | University Hospital, Basel, Switzerland | 30 | 2021-02-05 | 2022-04-13 |
Showing 20 of 27. Sign in to see all of them.
Diabetes Insipidus (13) · Hypopituitarism (6) · Polydipsia, Psychogenic (5) · Clostridium Infections (3) · Pituitary Diseases (3) · Social Isolation (3) · Combined Pituitary Hormone Deficiency (2) · Hypothalamic Diseases (2) · Mental Disorders (2) · Pituitary Neoplasms (2) · Acromegaly (1) · Anxiety Disorders (1) · Depression (1) · Diabetes Insipidus, Nephrogenic (1)
Female Urogenital Diseases (27) · Female Urogenital Diseases and Pregnancy Complications (27) · Kidney Diseases (27) · Male Urogenital Diseases (27) · Urogenital Diseases (27) · Urologic Diseases (27) · Endocrine System Diseases (26) · Pituitary Diseases (24) · Diabetes Insipidus (14) · Behavior (9) · Brain Diseases (8) · Central Nervous System Diseases (8) · Nervous System Diseases (8) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7)
Deamino Arginine Vasopressin (2) · norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination (2) · Blood Urea Nitrogen (1) · Chlorpropamide (1) · Estradiol (1) · Exenatide (1) · Magnetic Resonance Spectroscopy (1) · Melatonin (1) · N-Methyl-3,4-methylenedioxyamphetamine (1) · Organization and Administration (1) · Oxytocin (1) · Sodium Chloride (1) · Vasopressins (1)
University Hospital, Basel, Switzerland (11) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (3) · Elizabeth Austen Lawson (2) · Finch Research and Development LLC. (2) · Assistance Publique Hopitaux De Marseille (1) · Children's Hospital of Fudan University (1) · Christian Lodberg Hvas (1) · Ferring Pharmaceuticals (1) · Hospital Universitario 12 de Octubre (1) · Leiden University Medical Center (1) · Massachusetts General Hospital (1) · National Center for Research Resources (NCRR) (1) · Seoul National University Hospital (1)
Switzerland (11) · United States (6) · Spain (4) · Canada (2) · Netherlands (2) · China (1) · Denmark (1) · France (1) · Germany (1) · Japan (1) · South Korea (1)
Mirjam Christ-Crain, Prof. Dr. med. (4) · Mirjam Christ-Crain, Prof. (3) · Mirjam Christ-Crain, Prof. Dr. (3) · Anna Aulinas, MD PhD (2) · Elizabeth A Lawson, MD (2) · Christian L Hvas, PhD (1) · Elizabeth A Lawson, MD, MMSc (1) · Gary L. Robertson (1) · Jung Hee Kim, M.D (1) · Mirjam Christ-Crain, Prof. MD (1) · Zain Kassam, MD, MPH (1)
PMID 11555538, PMID 12794416, PMID 16931974, PMID 16931995, PMID 18305265, PMID 19841897, PMID 23811987, PMID 26125087, PMID 31970567, PMID 34599691, PMID 36152636, PMID 36620981, PMID 37192642, PMID 37510705, PMID 38003863, PMID 38392609, PMID 39366468, PMID 39547534, PMID 39824923, PMID 40383482, PMID 42082227
2023 (2), 2025 (2)